Newsletter 160 / December 28th 2014



Welcome to the 160th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.

The highlights of this week's newletter are a randomized controlled trial on perioperative oxygen delivery, full publication of the CHEER trial, a case series documenting REBOA use, Scandanavian guidelines on mechanical ventilation in ARDS, an editorial looking at the Ebola virus disease crisis at one year, a commentary on the SCCM pain, agitation and delirium guideline, corresondence describing the falling mortality rate in Sierra Leone, plus clinical review articles on TIPS and multi-drug resistant Acinetobacter baumannii.

This week's Topic of the Week is multi-drug resistant gram negative infections, starting with a paper on New Delhi metallo-beta-lactamase in tomorrow's Paper of the Day.


Review Articles:  Clinical Non-Clinical


Upcoming Meetings

Critical Care Reviews Meeting 2015

It's now less than four weeks until the Critical Care Reviews Meeting 2015, discussing the hottest trials of 2014. Studies being reviewed include the mechanical chest compression device studies CIRC and LINC; ALBIOS, investigating albumin in sepsis; TRISS, evaluating red cell transfusion thresholds in septic shock; OPTIMISE, looking at perioperative goal-directed haemodynamic therapy; SEPSISPAM, examining blood pressure targets in septic shock, PEITHO, exploring fibrinolysis in intermediate-risk PE, and a comparison of cerebral perfusion pressure-targeted therapy versus intracranial pressure-targeted therapy for raised intracranial pressure in paediatric CNS Infections. Chief investigators for three of the major RCTs presented at the Hot Topics Session of the European Society of Intensive Care Medicine meeting in Barcelona in October are present to discuss their work (CALORIES, HARP 2, VITdAL-ICU), as is the chief investigator for TTM. 2014 is the year of the early goal-directed sepsis therapy studies, and the chief investigator for ProMISe will be on hand to discuss the results of ProCESS & ARISE, as well as give an insight into the yet to finish UK sepsis study ProMISe. If this wasn't enough, there are also review talks from world experts on early mobilisation, ECMO, airway management, sepsis and neuroprognostication post cardiac arrest. Regardless if you're a believer in, or skeptic of, evidence-based medicine, you'll be amazed by the discussion on this recent paper exposing the fragility of the science we base our practice on.

The programme is available and online registration is open. With a global array of speakers, including the chief investigators for some of the biggest studies of the past 12 months, this is one of the most contemporary meetings around. Register early and don't miss out. There are only a few remaining hotel rooms available, so you'll need to book them today. Please feel free to contact me if you're thinking about making the trip - it would be great to hear from you.

SMACC Chicago

The workshops for the SMACC conference are rapidly filling, so if you are going, and plan on attending one, you had best register soon. Some have already sold out! If you're interested in evidenced-based medicine, Simon Carley, Rick Body and I willl be reprising last year's workshop. Ken Milne, Scott Aberegg and David Newman will be joining us for a North American view of how to interpret the literature. If you haven't heard about the greatest critical care conference in the world, then you need to visit the SMACC website.

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Critical Care Horizons

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. A call for papers has been issued, so if you have something interesting to say, and can say it in an engaging manner, please get in touch.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

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Randomized Controlled Trials

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Meta Analyses

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Observational Studies

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Cochrane Reviews



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Guidelines & Statements




Case Reports

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Clinical Review Articles 













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Non-Clinical Review Articles 

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I hope you find these links useful.

Until next week



Review Articles:  Clinical Non-Clinical