Major Studies on Stroke

Pathophysiology

  1. Brott. Early Hemorrhage Growth in Patients With Intracerebral Hemorrhage. Stroke. 1997;28:1-5

Therapy

Pharmacotherapy

Blood Pressure Control

  1. He. Effects of Immediate Blood Pressure Reduction on Death and Major Disability in Patients With Acute Ischemic Stroke. The CATIS Randomized Clinical Trial. JAMA 2014;311(5):479-489
  2. Anderson. Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage (INTERACT 2). N Eng J Med 2013;368:2355-2365  

Recombinant Factor 7

  1. Mayer. Efficacy and Safety of Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage. N Engl J Med 2008; 358:2127-213

Albumin

  1. Ginsberg. High-dose albumin treatment for acute ischaemic stroke (ALIAS) part 2: a randomised, double-blind, phase 3, placebo-controlled trial. Lancet Neurology 2013;epublished September 27th

Surgery

Clot Evacuation

  1. Medelow. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial.  Lancet 2005;365:387 - 397  (abstract)

Decompressive Craniectomy

  1. Jüttler. Hemicraniectomy in Older Patients with Extensive Middle-Cerebral-Artery Stroke (Destiny II). N Engl J Med 2014;370:1091-1100
  2. Vahedi. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol 2007;6(3):215–22.
  3. Jüttler. Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY). A Randomized, Controlled Trial. Stroke 2007;38:2518
  4. Vahedi. Sequential-Design, Multicenter, Randomized, Controlled Trial of Early Decompressive Craniectomy in Malignant Middle Cerebral Artery Infarction (DECIMAL Trial). Stroke. 2007;38:2506

Endovascular

  1. Berkhemer. A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke (MR CLEAN Trial). N Engl J Med 2014;epublished December 17th

 

Search