Welcome to the 300th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are a randomised controlled trial comparing a coping skills training program with an education program for survivors of critical illness, a guideline on safe medication use in the ICU, plus narrative reviews on cerebral oximetry, paediatric burn resuscitationand randomized, controlled trials in health insurance systems. There is also correspondence on the PRISMmeta analysis, physicians as dictatorsand why the best editors get fired.If you only have time for one review article this week, try this state-of-the-art paper on mechanical ventilation.
For this week's Topic of the Weekwe return to our series on system-based conditions, focusing on the renal system, starting with a paper on acute kidney injury in sepsis in tomorrow's Paper of the Day.
The big news this week is the addition to the Critical Care Reviews Meeting 2018 programme of both Prof Alexandre Cavalcanti (São Paulo), discussingthe ARTtrial investigating alveolar recruitment in ARDS, and an incredible editorial team of Prof Kathy Rowan (London), Prof Karin Amrein (Graz) and Prof Anders Perner (Copenhagen). These noted trialists will provide expert analysis on each major trial being presented. I think we have seven of the most interesting trials of the year to discuss - you won't want to miss out.
- Abstract: Cox. Effects of a Telephone- and Web-based Coping Skills Training Program Compared to an Education Program for Survivors of Critical Illness and Their Family Members: A Randomized Clinical Trial. Am J Respir Crit Care Med 2017;epublished September 5th
- Full Text: Gaudry. Loxapine to control agitation during weaning from mechanical ventilation. Critical Care 2017;21:235
- Full Text: Kahn. A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Critical Care 2017 21:234
- Abstract: El-Kersh. Enteral nutrition as stress ulcer prophylaxis in critically ill patients: A randomized controlled exploratory study. J Crit Care 2017;43:108-113
- Abstract: Gruther. Can Early Rehabilitation on the General Ward After an Intensive Care Unit Stay Reduce Hospital Length of Stay in Survivors of Critical Illness?: A Randomized Controlled Trial. Am J Phys Med Rehabil 2017;96(9):607-615
- Abstract: Ander. Time-to-intubation in obese patients. A randomized study comparing direct laryngoscopy and videolaryngoscopy in experienced anesthetists. Minerva Anestesiologica 2017;83(9):906-13
- Full Text: Gamberini. Resuscitative Endovascular Balloon Occlusion of the Aorta in trauma: a systematic review of the literature. World Journal of Emergency Surgery 2017;12:42
- Abstract: Llamas-Álvarez. Diaphragm and lung ultrasound to predict weaning outcome: systematic review and meta-analysis. Chest 2017;epublished August 29th
- Abstract: Bækgaard. The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies. Circulation 2017;136:954-965
- Full Text: Wu. Comparison of diagnostic accuracy in sepsis between presepsin, procalcitonin, and C-reactive protein: a systematic review and meta-analysis. Annals of Intensive Care 2017;7:91
- Abstract: Vignon. Hemodynamic assessment of septic shock patients using transpulmonary thermodilution and critical care echocardiography. A comparative study. Chest 2017;epublished August 30th
- Full Text: Wang. Opioid-associated iatrogenic withdrawal in critically ill adult patients: a multicenter prospective observational study. Annals of Intensive Care 2017;7:88
- Abstract: Grensemann. Validation of radial artery-based uncalibrated pulse contour method (PulsioFlex) in an unselected cohort of critically ill patients. Eur J Anaesthesiol 2017;epublished September 1st
- Abstract: Wang. Post-Resuscitation Arterial Oxygen and Carbon Dioxide and Outcomes after Out-of-Hospital Cardiac Arrest. Resuscitation 2017;epublished September 1st
- Abstract: Soliman. The ability of intensive care unit physicians to estimate long-term prognosis in survivors of critical illness. J Crit Care 2017;epublished September 7th
- Abstract: Stortz. Evidence for Persistent Immune Suppression in Patients WHO Develop Chronic Critical Illness After Sepsis. Shock 2017;epublished September 7th
- Fandino. Understanding the physiological changes induced by mannitol: From the theory to the clinical practice in neuroanaesthesia. J Neuroanaesthesiol Crit Care 2017;4:138-46
- Starnoni. Thrombolysis for non-traumatic intra-ventricular hemorrhage in adults: a critical reappraisal. Minerva Anestesiologica 2017;83(9):982-93
- Moerman. Recent advances in cerebral oximetry. Assessment of cerebral autoregulation with near-infrared spectroscopy: myth or reality? F1000Research 2017;6(F1000 Faculty Rev):1615
- Swain. Adjuvants to local anesthetics: Current understanding and future trends. World J Clin Cases 2017;5(8):307–323
- Tao. White Matter Injury after Intracerebral Hemorrhage: Pathophysiology and Therapeutic Strategies. Front Hum Neurosci 2017;11:422
- Imm. Postoperative delirium in a 64-year-old woman. Cleveland Clinic Journal of Medicine 2017;84(9):690-698
- Beghetti. Echocardiographic Evaluation of Pulmonary Pressures and Right Ventricular Function after Pediatric Cardiac Surgery: A Simple Approach for the Intensivist. Front Pediatr 2017;5:184
- Westerhof. Treatment strategies for the right heart in pulmonary hypertension. Cardiovascular Research 2017;epublished September 5th
- McCarthy. The management of antiplatelet therapy in acute coronary syndrome patients with thrombocytopenia: a clinical conundrum. European Heart Journal 2017;epublished September 8th
- Pham. Mechanical Ventilation: State of the Art. Mayo Clin Proc 2017;92(9):1382-1400
- Hachmann. Electrical Neuromodulation of the Respiratory System After Spinal Cord Injury. Mayo Clin Proc 2017;92(9):1401–1414
- Cortegiani. Ten important articles on noninvasive ventilation in critically ill patients and insights for the future: A report of expert opinions. BMC Anesthesiol 2017;17(1):122
- Baumann. Procalcitonin for Diagnostics and Treatment Decisions in Pediatric Lower Respiratory Tract Infections. Front Pediatr 2017;5:183
- Liere. Recent advances in hepatic encephalopathy. F1000Research 2017, 6(F1000 Faculty Rev):1637
- Smith. Pediatric liver failure: we came, we saw, but have we conquered? F1000Research 2017;6(F1000 Faculty Rev):1540
- Rondon-Berrios. Vasopressin Receptor Antagonists in Hyponatremia: Uses and Misuses. Front Med 2017;4:141
- Consolini. The Centenary of Immune Thrombocytopenia—Part 2: Revising Diagnostic and Therapeutic Approach. Front Pediatr 2017;5:179
- Muñoz. Current misconceptions in diagnosis and management of iron deficiency. Blood Transfus 2017;15:422-37
- Alhashem. Treatment of sepsis: What is the antibiotic choice in bacteremia due to carbapenem resistant Enterobacteriaceae? World J Clin Cases 2017;5(8):324–332
- Pierre. Diagnostic testing for Legionnaires’ disease. Annals of Clinical Microbiology and Antimicrobials 2017;16:59
- Srinivasan. Antibiotic stewardship: Why we must, how we can. Cleveland Clinic Journal of Medicine 2017;84(9):673-679
- Kalantari. Sepsis Definitions: The Search for Gold and What CMS Got Wrong. West J Emerg Med 2017;18(5):951-956
- Mirrakhimov. The Role of Sodium Bicarbonate in the Management of Some Toxic Ingestions. International Journal of Nephrology 2017;2017:7831358
- Matics. The Fragility Index in a Cohort of Pediatric Randomized Controlled Trials. J Clin Med 2017;6(8):79
- Romanowski. Pediatric burn resuscitation: past, present, and future. Burns & Trauma 2017;5:26
- Palmieri. Children are not little adults: blood transfusion in children with burn injury. Burns & Trauma 2017;5:24
- Ercole. Current and Emerging Technologies for Probing Molecular Signatures of Traumatic Brain Injury. Front Neurol 2017;8:450
- Bateman. The Effect of Sepsis on the Erythrocyte. Int J Mol Sci 2017;18(9)
- Shen. Neutrophil dysregulation during sepsis: an overview and update. J Cell Mol Med 2017;21(9):1687–1697
- Kane-Gill. Clinical Practice Guideline: Safe Medication Use in the ICU. Crit Care Med 2017;45(9):e877–e915
- NICE. Rehabilitation after critical illness in Rehabilitation after critical illness in adults. Epublished September 7th
- Iba. Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis. Journal of Intensive Care 2017;5:56
- Wanderer. Utilizing Ultrasound: Let US Help You with That Arterial Line! Anesthesiology 2017;127:A15
- Schneider. From Last to First — Could the U.S. Health Care System Become the Best in the World? N Engl J Med 2017;377:901-904
- Washington. The HITECH Era and the Path Forward. N Engl J Med 2017;377:904-906
- Halamka. The HITECH Era in Retrospect. N Engl J Med 2017;377:907-909
- Charlesworth. Anaesthetic gases, climate change, and sustainable practice. Lancet Planetary Health 2017;1(6):e216-e2172017;1(6):e216-e217
- Various. Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis. N Engl J Med 2017;377:994-995
- Jouffroy. Targeted therapeutic mild hypercapnia after cardiac arrest: a part of the bundle of care for mitigating secondary injury after cardiac arrest. Critical Care 2017;21:236
- Gaudry. Renal replacement therapy after cardiac surgery: do not ask “When”, ask “Why”. Critical Care 2017;21:231
- van Zanten. Hydrolysed protein enteral nutrition is not superior to polymeric whole protein feeding with regard to gastrointestinal feeding tolerance and feeding adequacy. Critical Care 2017;21:232
- Stanifer. Life-sustaining technologies in resource-limited settings. Lancet 2017;390(10099):1024
- Jha. Life-sustaining technologies in resource-limited settings – Authors' reply. Lancet 2017;390(10099):1024-1025
- Ludmir. The physician as dictator. Lancet 2017;390(10099):1023
- Horton. The best editors get fired. Lancet 2017;390(10099):1019
- Cerrato. Left Ventricular Free-Wall Rupture. N Engl J Med 2017;377:e13
- Kyo. Combined rupture of left ventricular free wall and pericardium. Intensive Care Med 2017;epublished September 4th
- Brigant. A febrile eruption after delivery. Intensive Care Med 2017;epublished September 4th
- Bedeir. Cardiac tamponade by colon. Intensive Care Med 2017;epublished September 5th
- Bhutani. Iatrogenic neck mobility restriction due to stereotactic fixed-frame application: Implications of a 'non-laryngoscopic' airway management approach. J Neuroanaesthesiol Crit Care 2017;4:175-7
It's now just 4 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in vasodilatory shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial BREATHE, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World"
This week we have also added both Prof Alexandre Cavalcanti (São Paulo), discussingthe ARTtrial investigating alveolar recruitment in ARDS, and an incredible editorial team of Prof Kathy Rowan (London), Prof Karin Amrein (Graz) and Prof Anders Perner (Copenhagen). The editorial team consists of noted trialists and will provide expert analysis on the major trials being presented.
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
#BMBTL17 is a conference on resuscitation that focuses on the skills and knowledge needed to bring your critically ill patients…back to life !
With cutting edge topics and a world class faculty, the conferences will be packed with clinical pearls and only the stuff that matters !
Ventilation, airway, EKGs, pediatric pearls, ultrasound and so much more…don’t miss this amazing conference ! It will be held on October 16th 2017 in downtown Montreal.
FemInEM.org is excited to bring you our first ever, in person conference, FIX2017! The FemInEM Idea Exchange is all about education, inspiration and motivation. Our world renowned faculty will speak from their hearts and minds, providing the substance and spark for you to change the world. We will meet, greet and motivate each other, pushing the limits of our previous selves. You won't want to miss it - October 4th to 6th, NYC.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board