Welcome to the 296th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are the LICORN randomized clinical trial, evaluating levosimendan in low output states post cardiac surgery; an expert statement on the management of atypical hemolytic uremic syndrome; and narrative reviews on paroxysmal sympathetic hyperactivity after acute brain injury, perioperative fluid managementand persistent air leaks. If you only have time for one review this week, try this paper on Rib Fractures: To Fix or Not to Fix?
This week's Topic of the Week is the latest in our series of general review articles on common conditions, continuing this week with miscellaneous respiratory conditions and a paper on severe hypoxemic respiratory failure in tomorrow's Paper of the Day.
The latest speaker for the Critical Care Reviews Meeting 2018 has been confirmed. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. In addition to this announcement, there will be more news over the next week or so regarding the programme. Although there are still plenty of places available for #CCR18, last year we sold out and we are way up on registrations compared with similar time points over the previous years. If you plan on attending, don't leave it too long before registering!
- Abstract: Cholley. Effect of Levosimendan on Low Cardiac Output Syndrome in Patients With Low Ejection Fraction Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass: The LICORN Randomized Clinical Trial. JAMA 2017;318(6):548-556
- Abstract: Efrati. Optimization of Endotracheal Tube Cuff Pressure by Monitoring CO2 Levels in the Subglottic Space in Mechanically Ventilated Patients: A Randomized Controlled Trial. Anesth Analg 2017;epublished August 4th
- Abstract: Logallo. Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial. Lancet Neurology 2017;epublished August 2nd
- Abstract: Mack. Effect of Cerebral Embolic Protection Devices on CNS Infarction in Surgical Aortic Valve Replacement. A Randomized Clinical Trial. JAMA 2017;318(6):536-547
- Abstract: Munro. Delirium prevention in critically ill adults through an automated reorientation intervention - A pilot randomized controlled trial. Heart Lung 2017;46(4):234-238
- Full Text: Rogers. Shortening cardioplegic arrest time in patients undergoing combined coronary and valve surgery: results from a multicentre randomized controlled trial: the SCAT trial. European Journal of Cardio-Thoracic Surgery 2017;52(2):288–296
- Abstract: Yu. Efficacy, Safety, and Preparation of Standardized Parenteral Nutrition Regimens: Three-Chamber Bags vs Compounded Monobags—A Prospective, Multicenter, Randomized, Single-Blind Clinical Trial. Nutr Clin Pract 2017;32(4):545–551
- Full Text: Yang. A comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials. BMC Nephrol 2017;18(1):264
- Full Text: Zhang. Effects of N-acetylcysteine treatment in acute respiratory distress syndrome: A meta-analysis. Experimental and Therapeutic Medicine 2017;epublished August 7th
- Abstract: Arabi. Critically Ill Patients With the Middle East Respiratory Syndrome: A Multicenter Retrospective Cohort Study. Crit Care Med 2017;epublished August 3rd
- Abstract: van den Berg. Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill. Am J Respir Crit Care Med 2017;epublished August 8th
- Abstract: Munshi. Oxygen Thresholds and Mortality During Extracorporeal Life Support in Adult Patients. Crit Care Med 2017;epublished August 3rd
- Abstract: Habes. Norepinephrine Contributes to Enterocyte Damage in Septic Shock Patients; a Prospective Cohort Study. Shock 2017;epublished August 3rd
- Full Text: Rodriguez. Regional citrate anticoagulation for continuous renal replacement therapy in pediatric patients with liver failure. PLoS One 2017;12(8):e0182134
- Abstract: Ortolano. External ventricular drain causes brain tissue damage: an imaging study. Acta Neurochir (Wien) 2017;epublished August 8th
- Full Text: Fujita. Relationship between dexmedetomidine dose and plasma dexmedetomidine concentration in critically ill infants: a prospective observational cohort study. Korean J Anesthesiol 2017;70(4):426-433
- Abstract: Stevens. The Critical Care Crisis of Opioid Overdoses in the United States. Ann Am Thorac Soc 2017;epublished August 11th
- Goh. Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy. Cochrane Database of Systematic Reviews 2017, Issue 8. Art. No.: CD002798
- Hummel. Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease. Cochrane Database of Systematic Reviews 2017, Issue 8. Art. No.: CD011312
- Meyfroidt. Paroxysmal sympathetic hyperactivity: the storm after acute brain injury. Lancet Neurology 2017;16(9):721-729
- Nayak. Practical approach to the patient with acute neuromuscular weakness. World J Clin Cases 2017;5(7):270-279
- Hurtado. Sugammadex: A neuromuscular blockade agent encapsulator. The Southwest Respiratory and Critical Care Chronicles 2017;5(20):44-49
- Shehabeldin. Management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. The Southwest Respiratory and Critical Care Chronicles 2017;5(20):33-43
- Sun. Pediatric skull fractures and intracranial injuries (Review). Experimental and Therapeutic Medicine 2017;14:1871-1874
- Ichord. Cerebral Sinovenous Thrombosis. Front Pediatr 2017;5:163
- Firsching. Coma After Acute Head Injury. Dtsch Arztebl Int 2017;114(18):313-20
- Bas. Updates on management of advanced heart failure. The Southwest Respiratory and Critical Care Chronicles 2017;5(20):12–21
- Kurmani. Acute Heart Failure: Definition, Classification and Epidemiology. Curr Heart Fail Rep 2017;epublished August 7th
- Ali. Inpatient Monitoring of Decompensated Heart Failure: What Is Needed? Curr Heart Fail Rep 2017;epublished August 12th
- Ahmad. Cardiac Three-Dimensional Printing Using Noninvasive Modalities: Will It Revolutionize. Cardiac Care? J Card Crit Care TSS 2017;1:4–7Cardiac Care? J Card Crit Care TSS 2017;1:4–7
- Ladha. Challenges in Multivalvular Heart Disease: Indian Scenario. J Card Crit Care TSS 2017;1:8–13
- Bennett. Perioperative fluid management: From physiology to improving clinical outcomes. Indian J Anaesth 2017;61:614-21
- Farah. Unmet goals in the treatment of Acute Myocardial Infarction: Review. F1000Research 2017;6(F1000 Faculty Rev):1243
- Bemelman. Rib Fractures: To Fix or Not to Fix? An Evidence-Based Algorithm. Korean J Thorac Cardiovasc Surg 2017;50(4):229-234
- Polverino. The Role of Neutrophil Elastase Inhibitors in Lung Diseases. Chest 2017;152(2):249-262
- Dugan. Management of Persistent Air Leaks. Chest 2017;152(2):417-423
- Ischaki. Nasal high flow therapy: a novel treatment rather than a more expensive oxygen device. Eur Respir Rev 2017;26(145)
- Amézquita-Trujillo. Considerations in pediatric patients with obstructive sleep apnea/hypopnea syndrome (OSAHS): From physiopathology to the perioperative period. Rev Colomb Anestesiol 2017;epublished June 20th
- Kumfer. Lady Windermere syndrome. The Southwest Respiratory and Critical Care Chronicles 2017;5(20):22-32
- Pangtey. Thyroid Emergencies: New Insight into Old Problems. J Assoc Physicians India 2017;65(8):68-76
- Mazzeffi. Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y12 inhibitors. Korean J Anesthesiol 2017;70(4):379-389
- Michelson. How I use laboratory monitoring of antiplatelet therapy. Blood 2017 130:713-721
- Shindo. Regional differences in antibiotic-resistant pathogens in patients with pneumonia: Implications for clinicians. Respirology 2017;epublished August 4th
- Khalafallah. Ebola virus disease: Essential clinical knowledge. Avicenna J Med 2017;7(3):96–102
- Akita. The neck burn scar contracture: a concept of effective treatment. Burns & Trauma 2017;5:22
- Greenhalgh. Sepsis in the burn patient: a different problem than sepsis in the general population. Burns & Trauma 2017;5:23
- Shim. Preoperative cardiac evaluation with transthoracic echocardiography before non-cardiac surgery. Korean J Anesthesiol 2017;70(4):390-397
- Lee. Anesthesia for ambulatory surgery. Korean J Anesthesiol 2017;70(4):398-406
- Tafur-Betancourt. The hidden world of drug interactions in anesthesia. Rev Colomb Anestesiol 2017;epublished June 20th
- Heil. Immunomodulatory effects of anesthetics in obese patients. World J Crit Care Med 2017;6(3):140-152
- Azoulay. Expert Statements on the Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome. Chest 2017;152(2):424–434
- The Japanese Respiratory Society Noninvasive Positive Pressure Ventilation (NPPV) Guidelines (second revised edition). Respir Investig 2017;55(1):83-92
- Gunst. Recovery from critical illness-induced organ failure: the role of autophagy. Critical Care 2017;21:209
- Neto. Focus on ARDS. Intensive Care Med 2017;epublished August 4th
- Ceccato. Rapid identification of antimicrobial resistance patterns allows a faster antibiotic adequacy. Critical Care 2017;21:208
- Umesh. Difficult airway: Challenges, phobias and options. Indian J Anaesth 2017;61:611-3
- Schneider. “Awake” ECCO2R superseded intubation in a near-fatal asthma attack. Journal of Intensive Care 2017;5:53
- Kong. Left-Middle-Lobe Pneumonia. N Engl J Med 2017;377:e8
- Aron. An 80-Year-Old Man With Asbestos Exposure Presenting With Respiratory Distress. Chest 2017;152(2):e25–e28
- Agrawal. The Curious Case of a 55-Year-Old Man With New-Onset Seizures. Chest 2017;152(2):e29–e32
- Patterson. Right Middle Lobe Collapse and Pleural Effusion in an 18-Year-Old Man. Chest 2017;152(2):e33–e38
- Patil. A 54-Year-Old Man With Anasarca, Dyspnea, and Recurrent Bilateral Pleural Effusions. Chest 2017;152(2):e39–e44
- Fakih. An 84-Year-Old Man With Progressive Dyspnea and an Abnormal Chest CT Scan. Chest 2017;152(2):e45–e49
- Dumas. Clostridium perfringens related spleen gangrene. Intensive Care Med 2017;epublished August 7th
It's now just 5 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Split between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3, the first large clinical trial examining angiotensin II in septic shock. We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year. There are still additional speakers to add to the programme, so the meeting will continue to grow and get better and better.
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
#BMBTL17 is a conference on resuscitation that focuses on the skills and knowledge needed to bring your critically ill patients…back to life !
With cutting edge topics and a world class faculty, the conferences will be packed with clinical pearls and only the stuff that matters !
Ventilation, airway, EKGs, pediatric pearls, ultrasound and so much more…don’t miss this amazing conference ! It will be held on October 16th 2017 in downtown Montreal.
FemInEM.org is excited to bring you our first ever, in person conference, FIX2017! The FemInEM Idea Exchange is all about education, inspiration and motivation. Our world renowned faculty will speak from their hearts and minds, providing the substance and spark for you to change the world. We will meet, greet and motivate each other, pushing the limits of our previous selves. You won't want to miss it - October 4th to 6th, NYC.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board