Welcome to the 307th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are randomised controlled trials on therapeutic hypothermia for newborns with hypoxic-ischemic encephalopathy, neuromuscular blockade in patients during targeted temperature management after resuscitation from cardiac arrest and the safety of the mechanical chest compression devices AutoPulse and LUCAS in cardiac arrest; observational studies on prehospital blood product transfusion for combat casualties in Afghanistan and the UK cost-utility analysis and secondary analyses of the ABLE trial; narrative reviews on extracorporeal life support in preoperative and postoperative heart transplant management and Clostridium difficile infection in the ICU ; plus editorials on thrombosis and bleeding and apparent research misconduct; as well as commentaries on fever control, individualized perfusion targets in post-cardiac arrest hypoxic ischemic brain injury and is this critically ill patient elderly or too old?.
This week's Topic of the Week is a series on research agendas from Intensive Care Medicine, starting with a paper on current research priorities in perioperative intensive care medicine in tomorrow's Paper of the Day.
There are now less than three months to #CCR18. We might have a surprise or two still to spring.... Don't miss out.....
- Abstract: Laptook. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy. A Randomized Clinical Trial. JAMA 2017;318(16):1550-1560
- Abstract: Stöckl. Continuous versus intermittent neuromuscular blockade in patients during targeted temperature management after resuscitation from cardiac arrest—A randomized, double blinded, double dummy clinical trial. Resuscitation 2017;120:14-19
- Full Text: Koster. Safety of mechanical chest compression devices AutoPulse and LUCAS in cardiac arrest: a randomized clinical trial for non-inferiority. European Heart Journal 2017;38(40):3006–3013
- Abstract: Montaigne. Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study. Lancet 2017;epublished October 26th
- Abstract: de Almeida. Early mobilization programme improves functional capacity after major abdominal cancer surgery: a randomized controlled trial. British Journal of Anaesthesia 2017;119(5):900–907
- Full Textt: Besch. Clinical Effectiveness of Intravenous Exenatide Infusion in Perioperative Glycemic Control after Coronary Artery Bypass Graft Surgery: A Phase II/III Randomized Trial. Anesthesiology 2017;127(5):775-787
- Abstract: Li. High-dose versus low-dose haemofiltration for the treatment of critically ill patients with acute kidney injury: an updated systematic review and meta-analysis. BMJ Open 2017;7(10):e014171
- Full Text: Rui. Dopamine versus norepinephrine in the treatment of cardiogenic shock: A PRISMA-compliant meta-analysis. Medicine 2017;96(43):e8402
- Full Text: Nistor. A Systematic Review of Neuroprotective Strategies during Hypovolemia and Hemorrhagic Shock. Int J Mol Sci 2017;18(11)
- Full Text: Dugernie. Aerosol delivery during invasive mechanical ventilation: a systematic review. Critical Care 2017;21:264
- Full Text: Pieczkoski. Noninvasive Ventilation During Immediate Postoperative Period in Cardiac Surgery Patients: Systematic Review and Meta-Analysis. Braz J Cardiovasc Surg 2017;32(4):301-311
- Abstract: Shackelford. Association of Prehospital Blood Product Transfusion During Medical Evacuation of Combat Casualties in Afghanistan With Acute and 30-Day Survival. JAMA 2017;318(16):1581-1591
- Abstract: Wang. Post-resuscitation arterial oxygen and carbon dioxide and outcomes after out-of-hospital cardiac arrest. Resuscitation 2017;120:113-118
- Abstract: Jouffroy. Early detection of brain death using the Bispectral Index (BIS) in patients treated by extracorporeal cardiopulmonary resuscitation (E-CPR) for refractory cardiac arrest. Resuscitation 2017;120:8–13
- Full Text: Ehmann. Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study. Critical Care 2017;21:262
- Abstract: Walsh. The Age of BLood Evaluation (ABLE) randomised controlled trial: description of the UK-funded arm of the international trial, the UK cost-utility analysis and secondary analyses exploring factors associated with health-related quality of life and health-care costs during the 12-month follow-up. Health Technol Assess 2017;21(62):1-118
- Rossor. Neurally adjusted ventilatory assist compared to other forms of triggered ventilation for neonatal respiratory support. Cochrane Database of Systematic Reviews 2017, Issue 10. Art. No.: CD012251
- Kennard. Interventions for treating central venous haemodialysis catheter malfunction. Cochrane Database of Systematic Reviews 2017, Issue 10. Art. No.: CD011953
- Klingenberg. Volume-targeted versus pressure-limited ventilation in neonates. Cochrane Database of Systematic Reviews 2017, Issue 10. Art. No.: CD003666
- Bermudez. Extracorporeal life support in preoperative and postoperative heart transplant management. Ann Transl Med 2017;5(20):398
- Cho. Stent thrombosis and optimal duration of dual antiplatelet therapy after coronary stenting in contemporary practice. Korean J Intern Med 2017;32(5):769-779
- Prechter. Sleeping with the enemy: Clostridium difficile infection in the intensive care unit. Critical Care 2017;21:260
- Lee. Feeding adequacy among Critically Ill Patients in the Intensive Care Unit and Its Association with Clinical Outcomes: A Narrative Review. Bangladesh Crit Care J 2017;5(2):113-121
Infectious Disease Clinics of North America Series
- Rowe. Sepsis in Older Adults. Infect Dis Clin N Am 2017;31(4):731–742
- Benson. Antimicrobial Pharmacokinetics and Pharmacodynamics in Older Adults. Infect Dis Clin N Am 2017;31(4):60617
- Henig. Bacterial Pneumonia in Older Adults. Infect Dis Clin N Am 2017;31(4):689–713Infect Dis Clin N Am 2017;31(4):689–713
- Cortes-Penfield. Urinary Tract Infection and Asymptomatic Bacteriuria in Older Adults. Infect Dis Clin N Am 2017;31(4):673–688Infect Dis Clin N Am 2017;31(4):673–688
- Schweizer. Septic Arthritis and Prosthetic Joint Infections in Older Adults. Infect Dis Clin N Am 2017;31(4):715–729Infect Dis Clin N Am 2017;31(4):715–729
- Donskey. Clostridium difficile in Older Adults. Infect Dis Clin N Am 2017;31(4):743–756Infect Dis Clin N Am 2017;31(4):743–756
- Talbot. Influenza in Older Adults. Infect Dis Clin N Am 2017;31(4):757–766Infect Dis Clin N Am 2017;31(4):757–766
- Kodama. Respiratory Syncytial Virus and Other Noninfluenza Respiratory Viruses in Older Adults. Infect Dis Clin N Am 2017;31(4):Infect Dis Clin N Am 2017;31(4):767–790
- Van Epps. Human Immunodeficiency Virus and Aging in the Era of Effective Antiretroviral Therapy. Infect Dis Clin N Am 2017;31(4):791–810Infect Dis Clin N Am 2017;31(4):791–810
- Karaolanis. Contemporary Strategies in the Management of Civilian Neck Zone II Vascular Trauma Front Surg 2017;4:56
- Fagin. Considerations for pediatric burn sedation and analgesia. Burns Trauma 2017;5:28
- Al-Tarrah. The influence of sex steroid hormones on the response to trauma and burn injury. Burns Trauma 2017;5:29
Intensive Care Medicine Series
- Gillies. Current research priorities in perioperative intensive care medicine. Intensive Care Med 2017;43(9):1173–1186
- Combes. The ICM research agenda on extracorporeal life support. Intensive Care Med 2017;43(9):1306–1318
- Flaatten. The status of intensive care medicine research and a future agenda for very old patients in the ICU. Intensive Care Med 2017;43(9):1319–1328
- Pandharipande. The intensive care delirium research agenda: a multinational, interprofessional perspective. Intensive Care Med 2017;43(9):1329–1339
- Kollef. The intensive care medicine research agenda on multidrug-resistant bacteria, antibiotics, and stewardship. Intensive Care Med 2017;43(9):1187–1197
- Pickkers. The intensive care medicine agenda on acute kidney injury. Intensive Care Med 2017;(9)43:1198–1209
- Nolan. Intensive care medicine research agenda on cardiac arrest. Intensive Care Med 2017;43(9):1282–1293
- Perner. The intensive care medicine research agenda on septic shock. Intensive Care Med 2017;43(9):1294–1305
- Asehnoune. The research agenda for trauma critical care. Intensive Care Med 2017;43(9):1340–1351
- Jaber. The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation. Intensive Care Med 2017;43(9):1352–1365
- Azoulay. The Intensive Care Medicine research agenda on critically ill oncology and haematology patients. Intensive Care Med 2017;43(9):1366–1382
- Møller. ICM focus on thrombosis and bleeding. Intensive Care Med 2017;epublished October 23rd
- Honore. Balanced crystalloids for the critically ill: knowledge on the rise but confusion still reigns! Ann Transl Med 2017;5(20):412
- Kharasch. Errors and Integrity in Seeking and Reporting Apparent Research Misconduct. Anesthesiology 2017;127:733-737
- Polastri. Meritocracy? Ask yourself. JICS 2017;18(4):276-278
- Martin. Oxygen therapy and the Goldilocks principle. JICS 2017;18(4):279-281
- Ng. The obesity conundrum in sepsis. BMC Anesthesiol 2017;17(1):147
- Robert. Is this critically ill patient elderly or too old? Intensive Care Med 2017;epublished October 26th
- Abouqal. Patient-physician relationship in specific cultural settings. Intensive Care Med 2017;epublished October 24th
- Torres. Adjuvant therapies in critical care: steroids in community-acquired pneumonia. Intensive Care Med 2017;epublished October 25th
- Klouche. Can this patient be safely weaned from RRT? Intensive Care Med 2017;epublished September 25th
- Abouqal. Patient-physician relationship in specific cultural settings. Intensive Care Med 2017;epublished October 24th
- Young. Fever control. Intensive Care Med 2017;epublished October 22nd
- Sekhon. Individualized perfusion targets in hypoxic ischemic brain injury after cardiac arrest. Critical Care 2017;21:259
- da Silva. Should copyright be transferred before a manuscript is accepted? Ann Transl Med 2017;5(20):415
- Lippi. How do I write a scientific article?—A personal perspective. Ann Transl Med 2017;5(20):416
It's now less than 3 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in septic shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART Trial. Prof Alexandre Biasi Cavalcanti (São Paulo) will explain this Brazilian investigation testing alveolar recruitment in ARDS.
We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World"
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board