Hot Articles

The following articles have been chosen as the most noteworthy publications in critical care since December 2011.

2019

Randomised Controlled Trials

American Thoracic Society Meeting

Pilot RCTs

Observational Studies

American Thoracic Society Meeting

Guidelines & Position Statements

Randomised Controlled Trials

Pilot RCTs

Guidelines & Position Statements

Randomised Controlled Trials

American College of Cardiology Meeting

Pilot RCTs

Guidelines & Position Statements

Randomised Controlled Trials

Society of Critical Care Medicine Congress 2019

Observational Studies

Guidelines & Position Statements

2018

Randomised Controlled Trials

Pilot RCTs

Observational Studies

Guidelines & Position Statements

Chinese Combat Injury Guidelines

American Society of Haematology Venous Thromboembolism Guideline

Randomised Controlled Trials

ESICM Trials

Non-ESICM Trials

Guidelines & Position Statements

Randomised Controlled Trials

Guidelines & Position Statements

Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials


Guidelines & Position Statements

2017

Randomised Controlled Trials

Guidelines & Position Statements

Laptook. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy. A Randomized Clinical Trial. JAMA 2017;318(16):1550-1560

Stöckl. Continuous versus intermittent neuromuscular blockade in patients during targeted temperature management after resuscitation from cardiac arrest—A randomized, double blinded, double dummy clinical trial. Resuscitation 2017;120:14-19

Koster. Safety of mechanical chest compression devices AutoPulse and LUCAS in cardiac arrest: a randomized clinical trial for non-inferiority. European Heart Journal 2017;38(40):3006–3013

The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society. Neurocrit Care 2017;epublished October 16th

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2017;epublished October 16th

Koch. A Randomized Clinical Trial of Red Blood Cell Transfusion Triggers in Cardiac Surgery. Ann Thorac Surg 2017;104(4):1243-1250

Jaillette. Impact of tapered-cuff tracheal tube on microaspiration of gastric contents in intubated critically ill patients: a multicenter cluster-randomized cross-over controlled trial. Intensive Care Med 2017;43(11):1562–1571

Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intnsive Care Med 2017;epublished October 31st

Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association / American Stroke Association. Stroke 2017;epublished November 2nd

Thiele. PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock (CULPRIT-SHOCK). N Engl J Med 2017;epublished October 30th

van Brunschot. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet 2017;epublished November 3rd

European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis – endorsed by the European Academy of Neurology. Eur J Neurol 2017;24:1203–1213

30th Annual ESICM Congress (LIVES2017, Vienna) 

New Engl J Med - Age of Transfused Red Cells

JAMA - Alveolar Recruitment in ARDS

JAMA - Intra-Operative Blood Pressure Management

JAMA - Systematic ICU Admission for Elderly Sick Patients

JAMA - Early Goal-Directed Sepsis Care in Zambia

Intensive Care Medicine - Early Goal-Directed Nutrition

Intensive Care Medicine - Airway Pressure Release Ventilation

Intensive Care Medicine - Spontaneous Breathing Trials

Intensive Care Medicine - Biomarker-Guided Strategy for Discontinuing Antifungal Therapy

Kneyber. Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC). Intensive Care Med 2017;epublished September 22nd


Intensive Care Medicine - Positioning for VAP


Intensive Care Medicine - Adrenal Insufficiency Guideline


Circulation - Cardiogenic Shock Guideline


Lancet Respiratory Medicine - Sedation Interruption


Chest - Checklists for ICU Intubation


Critical Care Medicine - Nebulized Versus IV Amikacin in VAP


European Respiratory Journal - HAP / VAP Guideline


Annals of Surgery - Transfusion Thresholds in Burns


Critical Care - Loxapine for Agitation


Critical Care - Recombinant ACE 2 in ARDS


J Crit Care - Enteral Nutrition as Stress Prophylaxis


Am J Respir Crit Care Med - Coping Skills in ICU Survivors


European Respiratory Journal - NIV Guideline

NEJM - Oxygen in Acute Myocardial Infarction


Crit Care Resusc - Earplugs for Sleep Quality


Resuscitation - Intermittent vs Continuous Neuromuscular Blockade during Temperature Management post Cardiac Arrest


JAMA - Ganciclovir in CMV-Positive Critically Ill Patients


Critical Care - Serlipressin in Septic Shock


Critical Care Medicine - Simulation for ECMO Emergencies


Critical Care Medicine - Exposure Keratopathy


Critical Care - Software-Guided Glycaemic Control


Thorax - Rehabilitation in the ICU

JAMA - 24 vs 48 Hours of Hypothermia post Cardiac Arrest


JPEN - Paediatric Nutritional Support Guideline


Journal of Intensive Care - Japanese ARDS Guideline


Chinese Medical Journal - EEG Monitoring Guideline


Lancet respiratory Medicine - Simvastatin for Prevention & Treatment of ICU Delirium


Journal of Critical Care - Furosemide in Early Acute Kidney Injury


Lancet - Procalcitonin-Guided Antibiotics in Early Sepsis


Minerva Pneumologica - NIV vs IMV in Hypoxaemic Respiratory Failure


JAMA Cardiology - Spironolactone in Acute Heart Failure


Anaesth Crit Care Pain - French TTM Guideline


World Jounal of Emergency Surgery - Intra-Abdominal Infections Guideline


Critical Care Medicine - Blood flow & CRRT Circuit Lifespan


European Heart Journal - Safety of Mechanical Chest Compression Devices


Journal of Korean medical Science - Mild Hypothermia for Poor Grade Subarachnoid Haemorrhage


Critical Care Medicine - Shenfu Injection post Cardiac Arrest


JAMA - Cooling post Neonatal Hypoxic-Ischaemic Encephalopathy

Circulation - N-Acetylcysteine & Nitrate Therapy in STEMI


Thorax - Post ICU Rehabilitation

McDowell. Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: a randomised controlled trial (the REVIVE trial) Thorax 2017;72:594-595


JAMA - FAST Scan in Paediatric Trauma


J Allergy Clin Immunol Pract - Icatibant for ACE Inhibitor-Induced Angioedema


Ann Emerg Med - High Flow Nasal Oxygen in Cardiogenic Pulmonary Oedema


Critical Care - Supplementary Parenteral Nutrition


JAMA Surgery - Intraoperative Dexmedetomidine & Post-Op Cognitive Dysfunction


Intensive Care Med - AKI Guideline

American Thoracic Society Conference

NEJM - Angiotensin II for Septic Shock


NEJM - Time to Treatment in Sepsis


JAMA - Outcome Prediction ICU



Thorax - BTS Oxygen Use Guideline


Crit Care Medicine - Paediatric & Neonatal Septic Shock Guideline


Neurology - Brain Injury after CPR Guideline


Chest - Positioning for Endotracheal Intubation


Resuscitation - Video versus Direct Laryngoscopy for Paramedic Endotracheal Intubation


European Journal of Anaesthesiology - Severe Perioperative Bleeding Guideline


Annals of Intensive Care - Post Extubation High Flow Nasal Oxygen


Crit Care Medicine - Stress Ulcer Prophylaxis


American Heart Journal - Nitric Oxide in Acute PE


N Eng J Med - Bystander Efforts in Out-of-Hospital Cardiac Arrest

Lancet - Tranexamic Acid for Post Partum Haemorrhage


Lancet Haematology - FFP vs Coagulation Factor Concentrates for Traumatic Coagulopathy


JAMA Internal Medicine - Antiviral Therapy for CMV Reactivation


Annals of Thoracic Surgery - Corticosteroids in Neonatal Cardiac Operations


JAMA - Postoperative Troponin Elevation in Noncardiac Surgery


Intensive Care Medicine - Immunoglobulin for Necrotising Soft Tissue Infection


New England Journal of Medicine - Ularitide in Acute Heart Failure


Intensive Care Medicine - NIV Post Extubation in Chronic Respiratory Disorders


Intensive Care Medicine - IV Chloride Restriction in Cardiac Surgery

Critical Care Medicine - Transfusion in Critically Ill Oncology Patients


J Trauma - Damage Control Resuscitation Guideline


J Crit Care - Tracheostomy Guideline


Intensive Care Med - Condolence Letter


JPEN J Parenter Enteral Nutr - Parenteral Nutrition Guideline


Intensive Care Medicine - Early Enteral Nutrition Guideline


Critical Care Medicine - Contrast-Induced Nephropathy


Critical Care - Pseudomonas Vaccine

Society of Critical Care Medicine Annual Congress

JAMA - Video vs Direct Laryngoscopy for Intubation in ICU

N Engl J Med - Therapeutic Hypothermia for Paediatric Cardiac Arrest

N Engl J Med - Paediatric Glycaemic Control

JAMA - Intubation during Cardiac Arrest


Crit Care Med - Surviving Sepsis Campaign Guidelines


Crit Care Med - Family-Centred Care Guidelines


Chest - Liberation from Mechanical Ventilation Guidelines

2016

NEJM - Age of Transfused Blood


NEJM - Tranexamic Acid for Coronary Artery Surgery


Intensive Care Medicine - High Flow Nasal Oxygen post Abdominal Surgery


Intensive Care Medicine - Balanced versus Unbalanced Crystalloids


Intensive Care Medicine - HFNO vs NIV for Pre-Oxygenation in Hypoxic ICU patients


Critical Care - Steroids in Early Sepsis-Associated ARDS


Am J Respir Crit Care Med - Helium / Oxygen in Exacerbations of COPD


Intensive Care Medicine - Intravascular Catheter Dressings


J Crit Care - Intensity of Feeding

ESICM 2016

NEJM - Levosimendan in Sepsis

JAMA - HFNO vs NIV

JAMA - OXYGEN-ICU

JAMA - EMPIRICUS

JAMA - Intubation during Paediatric Cardiac Arrest

Therapeutic Hypothermia & Cardiac Arrest

JAMA - Steroids in Sepsis

Intensive Care Medicine - Fluid Resuscitation in Sepsis


Intensive Care Medicine - Nitric Oxide during Cardiopulmonary Bypass


Intensive Care Medicine - NAVA


Intensive Care Medicine - IV Iron for Anaemia


Intensive Care Medicine - Recovery Programme


Lancet - Early, Goal-Directed Mobilisation


Critical Care Medicine - Dopamine vs Adrenaline in Septic Shock


 Neurosurgery - 4th Brain Trauma Foundation TBI Guideline


NEJM - High Flow Nasal Oxygen for Preterm Infants


Crit Care Med - Stress Ulcer Prophylaxis


Liver International - Vasopressor Support for Cirrhosis & Septic Shock


NEJM - Decompressive Craniotomy


Am J Respir Crit Care Med - Sevoflurane for Sedation ARDS


Chinese Medical Journal - Evaluation of Coma after Cardiac Arrest


N Engl J Med - Factor Xa Inhibitor Related Bleeding

Lancet Respiratory Medicine - Sedation & Analgesia


JAMA Cardiology - Nonshockable Out-of-Hospital Cardiac Arrest


Shock - Hydrocortisone in Septic Shock


JAMA Internal Medicine - Sodium Selenite & Procalcitonin in Sepsis


Journal of Critical Care - Heparin for Pneumonia in Ventilated Patients


European Heart Journal - Acute Heart Failure Guideline


Clinical Infectious Diseases - HAP & VAP Guideline


Am J Respir & Crit Care Med - Burnout Syndrome in Critical Care Professionals


JAMA - Palliative Care-Led Meetings

Lancet - Platelet Transfusion in Haemorrhagic Stroke


JAMA - Timing of Renal Replacement Therapy in AKI


American Thoracic Society Meeting

New England Journal of Medicine:     Timing of Renal Replacement Therapy in AKI

JAMA:     Aspirin for the Prevention of ARDS

JAMA:     Helmet NIV for ARDS

American Journal of Kidney Disease:     Renal Replacement Therapy Dose


Journal of the American College of Cardiology:     Early Aldosterone Blockade in Acute MI


Resuscitation:     Video Laryngoscopy during CPR


Critical Care:     European Guideline on Bleeding & Coagulopathy post Trauma


JAMA:     Checklists


Resuscitation:     Hypercapnoea post Cardiac Arrest


NEJM:     Antiarrhythmics in Out-of-Hospital Cardiac Arrest


Critical Care:     Steroids for Refractory Shock post Cardiac Arrest


Intensive Care Medicine:     Probiotics for the Prevention of VAP

Brussel's International Symposium on Intensive Care & Emergency Medicine

JAMA:  Dexmedetomidine Sedation in ICU

JAMA: High-Flow Nasal Oxygen post Extubation

JAMA: Non-Invasive Ventilation post Extubation after Abdominal Surgery

JAMA: Secondary Infections post Sepsis

NEJM: Early TPN in Childern


Critical Care Medicine:  Fragility Index in Critical Care


Journal of Infection - UK Meningitis Guidelines


JAMA - Sepsis Definition


JAMA - Statins for AKI


JAMA - ARDS Epidemiology

Lancet Respiratory Medicine - Effect of Light on Delirium


Intensive Care Medicine - Blood Pressure Targets in Shock


NICE Trauma Guideline


JAMA - Acetazolamide for COPD


Intensive Care Medicine - Percutaneous Dilational Tracheostomy


Pediatric Crit Care Med - Aminophylline for Prevention of AKI

Blue Journal - End-of-Life Communication


JPEN J Parenter Enteral Nutr - Nutritional Support in the Critically Ill


Intensive Care Medicine - Continuous vs Intermittent Beta Lactam Infusion


Chest - Antithrombotic Therapy for VTE


Resuscitation - TTM post Cardiac Arrest


German Medical Society - Delirium, Analgesia & Sedation Guideline


Annals of Intensive Care - Renal Replacement Therapy Guideline


ANZICS - Acute Pain Management Scientific Evidence

2015

Journal of Thrombosis and Haemostasis - Guideline on Antidotes for Direct Oral Anticoagulants


American Journal of Respiratory & Critical Care Medicine:     Physical Therapy for Respiratory Failure


NICE Guideline on Acute Heart Failure


NICE Guideline on IV Fluid Therapy in Young People


Journal of Trauma:  Western Trauma Guidelines


Critical Care Medicine:     SCCM Guideline on Ultrasound in Critical Care


Critical Care Medicine: SCCM Guideline on Organ Procurement


Critical Care Medicine:    SCCM Guideline on ICU Process & Structures


Lancet Infectious Diseases:     Body Surface Decolonization & UTIs


JAMA:     Transfusion in Anaemic Children with Elevated Lactate

Intensive Care Medicine:  Post-Resuscitation Care Guideline


American Heart Association:  ST-Elevation MI Guideline Update


American Heart Association:  Infective Endocarditis Guideline


2015 Cardiac Arrest Guidelines

  1. Part 1: Executive Summary: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S315-S367
  2. Part 2: Evidence Evaluation and Management of Conflicts of Interest: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S368-S382
  3. Part 3: Ethical Issues: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S383-S396
  4. Part 4: Systems of Care and Continuous Quality Improvement: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S397-S413
  5. Part 5: Adult Basic Life Support and Cardiopulmonary Resuscitation Quality: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S414-S435
  6. Part 6: Alternative Techniques and Ancillary Devices for Cardiopulmonary Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S436-S443
  7. Part 7: Adult Advanced Cardiovascular Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S444-S464
  8. Part 8: Post–Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S465-S482
  9. Part 9: Acute Coronary Syndromes: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S483-S500
  10. Part 10: Special Circumstances of Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S501-S518
  11. Part 11: Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S519-S525
  12. Part 12: Pediatric Advanced Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
  13. Circulation 2015;132:S526-S542
  14. Part 13: Neonatal Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S543-S560
  15. Part 14: Education: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132:S561-S573

ESICM Hot Topics and New Trials

N Engl J Med:     Plasmalyte vs Saline

JAMA:     Paracetamol for Fever in Critically ill with Suspected Infection

Lancet:     Erythropoietin for Traumatic Brain Injury

N Engl J Med:     Hypothermia for Intracranial Hypertension in Traumatic Brain Injury


Am J Respir Crit Care Med:     Apnoeic Oxygenation

JAMA:     ICU Admission for Older Adults with Pneumonia


JAMA:     Do-Not-Resuscitate Status


 

NEJM:     CVC Insertion Site


Clinical Drug Investigation:  Esmolol for Sepsis


Lancet:     Methylprednisolone for Cardiopulmonary Bypass


Lancet:     Sigmoid Diverticulitis

Lancet:  CVC Line Infection Prevention


American Journal of Respiratory & Crit Care Med:     End-of-Life Care


Critical Care:     Laxative Therapy


Lancet:  Oxyenation Target in Bronchiolitis


Lancet:  Bubble CPAP for Paediatric Pneumonia


European Journal of Anesthesiology:     Pre-Oxygenation


Critical Care Medicine:     Vasopressors for Paediatric Septic Shock


Blue Journal:     Oxygenation Targets in Mechanically Ventilated Patients


Journal of Hepatology:     Plasma Exchange for Acute Liver Failure


Circulation:     ESC Guidelines on Pulmonary Hypertension | Pericardial Disease | Non-Persistent ST Elevation Coronary Syndromes | Infective Endocarditis

British Journal of Haematology:     Guideline on Admission for Haematology Cancer Patients


Journal of Trauma:  Early Surgery in Traumatic Brain Injury


Annals of Surgery:     Cryopreserved Packed Red Cells


NEJM / Lancet:     Idarucizumab for Dabigatran


Lancet:     Bioprosthetic Total Artificial Heart Heart


New England Journal of Medicine:     Hypothermia for Deceased Kidney Donor Graft

JAMA:     Bystander CPR


Blue Journal:     β-Lactam Infusion in Severe Sepsis


Perioperative Medicine:     Stroke Volume Variation


Critical Care Medicine:    Critical Care Interventions


Blue Journal:     Haemofiltration for Postcardiac Surgery Shock


Annals of Surgery:     Abdominal Vacuum Therapy post Laparotomy


Annals of Intensive Care:     Guideline on Cardiogenic Shock

Journal of Trauma:     Guideline on ED Thoracotomy


Critical Care Medicine:     Hypothermia for Paediatric Traumatic Brain Injury


Circulation:     Targeted Temperature Management


New England Journal of Medicine:     Out-of-Hospital CPR


New England Journal of Medicine:     Stroke Thrombolysis


New England Journal of Medicine:     Stroke Thrombectomy


Blue Journal:     Guideline on Requests for Inappropriate ICU Therapy


Blue Journal:     Guideline on Managing Conscientious Objections in ICM


Journal of Cardiac Failure:     Statement on Percutaneous Mechanical Circulatory Support

European Heart Journal:     Guideline on Acute Heart Failure


Stroke:     Guideline on Spontaneous Intracerebral Haemorrhage


Critical Care Medicine:     Talactoferrin for Sepsis


New England Journal of Medicine:     Intra-Abdominal Infection


American Thoracic Society Meeting 2015

New England Journal of Medicine:     Underfeeding

New England Journal of Medicine:     High Flow Nasal Oxygen

Journal of the American Medical Association:     High Flow Nasal Oxygen


Lancet:     Red Cell Transfusion in Upper GI Haemorrhage


 British Medical Journal:     MRSA Therapy


AJRCCM:     GUIDELINE - Conscientious Objections in ICU

Intensive Care Society:     Provision of Intensive Care Servces


Neurocritical Care:     Hemispheric Infarction


Neurocritical Care:     Devastating Brain Injury


Swiss Medical Weekly:     Ethics in ICU


New England Journal of Medicine:     Paediatric Therapeutic Hypothermia post Cardiac Arrest


New England Journal of Medicine:     Alcoholic Hepatitis


Intensive Care Medicine:     High Flow Nasal Cannulae Oxygen for Intubation


JAMA Internal Medicine:     Post ICU Rehabilitation


Intensive Care Medicine:     Polymyxin B Hemoperfusion


Chest:     Surfactant in ARDS


Intensive Care Medicine:    Early Rehabilitation


Critical Care Medicine:     Regional Citrate Anticoagulation for RRT


NEJM:     Age of Transfused Red Cells