Critical Care Reviews Meeting

The best critical care trials in the world

CCR23     June 14th to 16th

CCR24     June 12th to 14th

Trial Results Presenters

First presentations of major trials results


Giovanni Landoni

Giovanni Landoni

Co-Chief Investigator, MERCY Trial

Prof Giovanni Landoni, MD, is currently Full Professor at Vita-Salute San Raffaele University, Milan, and Director of the Center for Intensive Care and Anesthesiology of San Raffaele Scientific Institute. In the period 2006-2022 he participated to ideation, writing and implementation of 25 grants that got funding from national and international donors and attracted 15 further trials supported by grants from abroad.

His strong clinical and research interests in intensive care and anesthesia resulted in more than 600 scientific publications in indexed journals, cited >20,000 times, HI=68) including randomized trials on NEJM, Lancet, and JAMA, and over 100 invitations in international congresses. He participated to 47 randomized controlled trials. Prof Landoni was Chief Investigator in successfully completed multicenter randomized clinical trials that randomized > 10,000 critically ill or perioperative patients over the last 10 years.

He spent three years abroad performing research and working in the U.S.A., Spain, the Netherlands, India (where he married) and Uganda. He filed applications for 6 patents in the field.
He coordinated the Mercy Trial (Meropenem bolus versus continuous infusion in ICU patients) in 4 countries.

Twitter: @giovannilandoni

Giacomo Monti

Giacomo Monti

Co-Chief Investigator, MERCY Trial

Giacomo Monti is an Associate Professor of Anaesthesiology and Intensive Care Medicine at Vita-Salute San Raffaele University in Milan, Italy and Senior Consultant in Intensive Care Medicine of San Raffaele Hospital, which is a prominent research and clinical facility in Italy, with more than 100 laboratories and 1200 researchers, 60 clinical units and more than a million of patients treated a year.

He is also chair of the High Fidelity Simulation Lab and member of the steering committee of the Center for Research in Anaesthesia and Intensive Care. He is leading a collaboration with hematologists for advanced cellular treatments in different diseases.

His clinical and research interest embrace respiratory failure, especially when treated by non invasive ventilation outside the classical setting of intensive care units or when caused by Sars-COV-2 virus. He is Principal Investigator for currently running projects related to prevention of fibrosis in ARDS (Pioneer trial) and for innovative treatment of sepsis (PPI-Sepsis trial).
Giacomo has served as co-principal investigator for the Mercy Trial from its first very first ideation to the very end results and publication.

Twitter:  @GiacomoMonti

Mark Peters

Chief Investigator, OXY-PICU Trial
Mark Peters is Professor of Paediatric Intensive Care at UCL Great Ormond Street Institute of Child Health in London and Honorary Consultant at GOSH PICU and the Children’s Acute Transport Service.
His research is in pragmatic multiple centre randomised trials in Paediatric Critical Illness having been Chief Investigator on Oxy-PICU, FEVER and SCARF and a contributor to FIRST-ABC, FiSh, SandWiCh, ChiP, TRI-PICU. He edits paediatric contributions to Intensive Care Medicine, and is European Co-Chair of the Paediatric Surviving Sepsis campaign.

Twitter:  @pus27

Karim Brohi

Karim Brohi

Chief Investigator, CRYOSTAT-2

Karim Brohi is the Clinical Director of the London Major Trauma Network, Professor of Trauma Sciences at Queen Mary University of London and a Consultant vascular and trauma surgeon for Barts Health NHS Trust at the Royal London Hospital. Karim Brohi is a Professor of Trauma Sciences and founding director of the Centre for Trauma Sciences, and Director of the pan-faculty Crisis Prevention, Management and Recovery Network. He is a consultant trauma and vascular surgeon at the Royal London Major Trauma Centre, part of Barts Health NHS Trust; and director of the London Major Trauma System for NHS England. He is also a Non-Executive Director of the London Ambulance Service NHS Trust. Professor Brohi founded the MSc in Trauma Sciences programme at the Centre for Trauma Sciences. Beginning in 2011, the programme now has hundreds of alumni around the world. Professor Brohi continues to deliver trauma education through online media as well as being invited keynote speaker at many events worldwide.

Twitter:  @karimbrohi

Glenn Eastwood

Chief Investigator TAME Trial

Dr Glenn Eastwood is the Chief Investigator for the Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest randomised controlled trial (TAME Cardiac Arrest Trial). Dr Eastwood holds a Research Doctorate (PhD) with Deakin University in research dedicated to oxygen therapy for patients at risk of respiratory dysfunction. His research program is focused on the impact and outcome of gas management (oxygen and carbon dioxide) in critically ill patients and he has published widely in this area.

Glenn is a Senior Research Fellow in the School of Public Health and Preventive Medicine, Monash University. Glenn also manages the Intensive Care research program at the Austin Hospital in Melbourne and is widely acknowledged as a leading research coordinator within the Australian and New Zealand Intensive Care Society - Clinical Trials Group (ANZICS-CTG). In addition, he is the Immediate Past-Chair of the Australian and New Zealand Intensive Care Research Coordinator Interest Group (IRCIG), which is an endorsed working group of the ANZICS CTG.

Twitter: @Eastwoodgm

Russell Gruen

Russell Gruen

Chief Investigator PATCH-Trauma Trial

Professor Russell Gruen is an Australian trauma surgeon who practised at The Alfred and Royal Melbourne Hospitals, was Professor of Surgery and Public Health at Monash University, and was Director of the National Trauma Research Institute. He is now Dean of the College of Health and Medicine at The Australian National University. Throughout his career he has combined clinical activities with trauma system development work in low, middle and high income countries, including remote areas with long prehospital times. He established the Australian Trauma Registry and was its first chair, led an Australia-India trauma system collaboration, and was a co-founder of the WHO Global Alliance for Care of the Injured.

In addition to the PATCH-Trauma Trial, Russell led a national cluster RCT of emergency management of mild TBI, and was a Lancet Commissioner in Global Surgery and in Traumatic Brain Injury. Russell has held the leading clinician scientist awards of the National Health and Medical Research Council and the Royal Australasian College of Surgeons, and is an elected Fellow of the Australian Academy of Health and Medical Sciences, the International Surgical Society, and the Academy of Medicine of Singapore.

Twitter: @RussellGruen

Stephen Bernard

Stephen Bernard

Investigator, PATCH-Trauma & TAME Trials

Professor Stephen Bernard is an Intensive Care Specialist at The Alfred and the Victorian Heart Hospitals, Director of Intensive Care at Knox Private Hospital and Medical Advisor to Ambulance Victoria. He is an Adjunct Professor in the Department of Epidemiology and Preventive Medicine at Monash University.

He has been a Chief Investigator in numerous clinical trials funded by the Australian National Health and Medical Research Council. In out-of-hospital cardiac arrest patients, the “EXACT” trial tested the reduction of oxygen early after resuscitation, “TAME” tested therapeutic hypercapnia after admission to ICU and “RINSE” tested pre-hospital therapeutic hypothermia. In trauma patients, “PATCH” tested the role of tranexamic acid in patients with suspected bleeding. In patients with severe TBI, “POLAR” tested early therapeutic hypothermia and the “RSI” trial tested paramedic rapid sequence intubation. The “ICED” trial tested early therapeutic hypothermia in patients with complete spinal cord injury.

Twitter: @AmbVicMedic

Brian Burns

Investigator PATCH-Trauma Trial
A/Professor Brian Burns is an emergency physician at Northern Beaches Hospital and Royal North Shore Hospital, Sydney. He is a prehospital and retrieval medicine specialist with Greater Sydney Area HEMS, NSW Ambulance. Trauma consultant at Royal North Shore Hospital.
Resuscitation/cardiovascular trials: Co-Chief investigator EVIDENCE cardiac arrest trial (expedited transport vs standard care in refractory cardiac arrest), investigator ESCAPE-CS trial. Trauma trials: FEISTY-2 trial (fibrinogen concentrate vs cryoprecipitate in severe trauma), SABRE trial (serratus plane block + CHiP vs ChIP in rib fractures). Airway trials- investigator FAKT, AFAKT. 
Faculty: ATACC, Resuscitology, STRESS Courses. A/Professor of Emergency Medicine, Sydney Medical School, Sydney University. Honorary Senior Lecturer, Blizard Institute, Queen Mary, University of London. 

Twitter: @HawkmoonHEMS

Marion Campbell

Co-Chief Investigator UK REBOA Trial

Marion Campbell is Vice-Principal (Research) for the University of Aberdeen and Professor of Health Services Research in the Health Services Research Unit (HSRU).   Marion is a medical statistician and clinical trialist. Her main research interests are in the design, conduct and analysis of clinical trials, especially complex trial design and the design and conduct of surgical and device trials.  She has published widely on clinical trials methodology, including on cluster randomised trials, design of trials of non-pharmacological interventions, pragmatic trials and trials reporting.  She has served on many national and international funding agencies and committees and is an elected Fellow of the Royal Society of Edinburgh, the Faculty of Public Health and the International Society for Clinical Trials.

Marion graduated with an honours degree in Statistics from the University of Aberdeen and subsequently gained an MSc in Statistics and PhD in Public Health.  Following early career appointments within the National Health Service in the fields of Operational Research and Statistics of Medical Audit, she joined the Health Services Research Unit in 1993.  She became Director of the Unit in 2007 - a position she held until the end of 2015, when she became Dean of Research for Life Sciences and Medicine.  She took up the role of Vice-Principal (Research) in October 2017.  HSRU remains her academic base.

Twitter:  @MarionKCampbell

Jan Jansen

Chief Investigator REBOA Trial

Jan Jansen is Professor at the Division of Trauma & Acute Care Surgery, Director at the Center for Injury Science, and Associate Vice Chair for Clinical Trials at the University of Alabama at Birmingham, USA.

His undergraduate medical training took place in the United Kingdom where he obtained his medical degree (MBBS) in 1997 and an intercalated Bachelor of Science degree in anatomy in 1994. His postgraduate training took place in Scotland, with trauma and critical care medicine fellowships in Johannesburg and Toronto. He is a fellow of the Royal College of Surgeons of England and a fellow of the Faculty of Intensive Care Medicine of the Royal College of Anaesthetists. Dr. Jansen served in the British Army as a reservist and was awarded a Queen’s Commendation for his service in Afghanistan.

Dr. Jansen holds a Doctorate of Medicine from the University of Berlin and a Ph.D. from the University of Aberdeen. Between 2013 and 2016, he was the recipient of an NHS Research Scotland (NRS) Fellowship. He is a former Moynihan Travelling Fellow of the Association of Surgeons of Great Britain and Ireland.

Dr. Jansen’s principal research interest is clinical trials. He has particular expertise in the evaluation of medical devices and complex interventions, and Bayesian trial designs. He is the principal investigator of several clinical trials, in the United States and United Kingdom, including the UK REBOA Trial.

Twitter:  @janjansenuk

Matthew Semler

Chief Investigator DEVICE Trial

Matthew W. Semler MD, MSc is an Assistant Professor of Medicine and Biomedical Informatics in the Division of Allergy, Pulmonary, and Critical Care Medicine at Vanderbilt University. Dr. Semler is a critical care physician and Associate Director of the Medical Intensive Care Unit at Vanderbilt University. Dr. Semler’s federally-funded research identifies non-patient-centered variation in current clinical practice, embeds pragmatic randomized trials into clinical care to understand which treatments produce the best outcomes for which patients, and implements the results into practice. Randomized trials he has helped lead, including six published in the New England Journal of Medicine or JAMA, have challenged longstanding dogma around common practices in fluid management, airway management, and respiratory support. Dr. Semler serves as Chair of the Steering Committee for the Pragmatic Critical Care Research Group, co-director of the Inpatient Division of the Learning Healthcare System at Vanderbilt University, and a member of the protocol committee for trials within the NHLBI PETAL Network.

Matthew Prekker

Matthew Prekker

Study Chair DEVICE Trial
Matt Prekker is an Associate Professor of Medicine (Pulmonary, Allergy, and Critical Care) and Emergency Medicine at Hennepin County Medical Center and the University of Minnesota Medical School, both in Minneapolis, Minnesota, USA. 

After combined residency training in emergency medicine and internal medicine at Hennepin, and a fellowship in pulmonary/critical care at the University of Washington-Seattle, Dr. Prekker practices as both an emergency physician and pulmonary/critical care specialist at Hennepin County Medical Center, where he also directs the ECMO program.  His clinical research interests center on the care of critically ill adults and children, especially airway management, respiratory failure, and the use of ECMO for less common indications such as poisonings and environmental hypothermia. 

Dr. Prekker is on the Executive Committee of the Pragmatic Critical Care Research Group (PCCRG) and has helped lead the BOUGIE and DEVICE trials.  He is also involved in clinical trials in emergency medicine and critical care funded by the National Institutes of Health and Centers for Disease Control and Prevention.

Trial Review Presenters

Presentations of trials published in the past year


Lisa Higgins

Lisa Higgins

Lead, REMAP-CAP 180 Day Outcomes

Dr. Lisa Higgins is a Senior Research Fellow and Lead of the Health Economics Program at the Australian and New Zealand Intensive Care Research Centre (ANZIC-RC) at Monash University, Australia. Her research program focuses on the long-term outcomes of critically ill patients, evaluating the costs of care in critical illness and conducting economic evaluations alongside clinical trials in critical care. Her work is funded by an Emerging Leader Investigator Grant from the National Health and Medical Research Council, Australia. In 2020 and 2021, Lisa led the data coordination team and currently lead the health economics program for the REMAP-CAP trial, an international Bayesian platform trial being conducted in >300 sites in >20 countries, which has provided crucial evidence to inform national and international guidelines for the management of COVID-19 in critically ill patients. Lisa is a member of the Australasian Clinical Trials Alliance’s (ACTA) Health Economics alongside Trials (HEAT) group and was a key member of ACTA’s Research Prioritisation Reference Group. She also serves on the Victorian ECMO Service’s Strategic Research Working Group, the ANZICS CORE Patient Reported Outcomes and Experience Measures Working Party and is on the editorial board for Australian Critical Care.

Twitter: @iculisah

Ivor S. Douglas

Ivor S. Douglas

Co-Chief Investigator CLOVERS Trial

Ivor S. Douglas, MD, FRCP(UK) is Professor of Medicine at the University of Colorado, and Chief of Pulmonary and Critical Medicine at Denver Health Medical Center where he has directed the medical ICU since 2002.

Having graduated medical school in South Africa and after Internal Medicine Residency training in London, Great Britain, he completed pulmonary & critical care fellowship training the University of Chicago.

Dr. Douglas is principal investigator for ongoing investigations in several aspects of critical care, including basic mechanistic studies in acute lung injury, sepsis and septic shock and therapeutic strategies for shock resuscitation and long-term outcomes in the critically ill. Dr. Douglas serves on the steering committees and safety monitoring boards for multicenter international studies in critical illness. Dr. Douglas directs an NIH, DoD and industry funded research program exploring sepsis, ARDS and long-term outcomes from critical illness. His work in critical care leadership and health services include sepsis resuscitation programs using Lean systems engineering techniques. He has authored or co-authored over 100 scientific publications and book chapters and is the co-Editor of Principles of Critical Care, the preeminent textbook in the field.

Dr. Douglas has received teaching awards at the U. Chicago, Columbia University, and U. Colorado. Dr. Douglas served as chair of the American Thoracic Society’s Health Policy Committee and the ATS Critical Care Assembly program committee for 2014-16. Dr. Douglas has been recognized annually since 2008 in Denver 5280’s “Top Doc” and “Best Doctors in America” lists.

He is Fellow of the Royal College of Physicians (FRCP) and is an avid music listener, genealogist and tennis player.

Twitter:  @com543

Carol Hodgson

Chief Investigator TEAM Trial

Professor Carol Hodgson is Head of the Division of Clinical Trials and Cohort Studies in the School of Public Health and Preventive Medicine, and Deputy Director of the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia. She has held NHMRC funding throughout her career, as PhD scholarship, Early Career Fellowship and currently with an Investigator Grant (2020-2024). She is a Specialist Physiotherapist in Intensive Care at The Alfred Hospital, Melbourne, Australia. She sits on the Executive and Scientific Committee of the International ECMO Network (ECMONet), the Guidelines Leadership Group for National COVID-19 Clinical Evidence Taskforce and is a Council Member of the International Forum of Acute Care Trialists (InFACT).

Carol leads international multicentre trials for the Australian and New Zealand Intensive Care Society Clinical Trials Group. She has over $20M in grant funding and over 190 publications, with expertise in long-term functional recovery after critical illness. She has contributed to international guidelines for the management of patients with acute respiratory distress syndrome, sepsis and COVID-19, including recommendations for the use of mechanical ventilation, high-flow nasal therapy, oxygen, extracorporeal membrane oxygenation, and early rehabilitation.

Twitter:  @chodgsonANZICRC

Nina Christine Andersen-Ranberg

Coordinating Investigator AID-ICU Trial

Nina Christine Andersen-Ranberg, MD, is a PhD student at the Department of Anesthesiology and Intensive Care, Zealand University Hospital, Denmark and the University of Copenhagen.

Dr Andersen-Ranberg is the Coordinating Investigator of the AID-ICU trial. Her primary research focus is delirium
and sedation in critically ill patients. She has a general interest in clinical trials and is a proud member of Collaboration for Research in Intensive Care (CRIC) where she has been involved in most of the recent trials from the group; SUP-ICU, HOT-ICU, COVID-STEROID 1+2 and CLASSIC.

Twitter:  @ARanberg

Anders Perner

Anders Perner

Chief Investigator, AID-ICU Trial

Anders Perner is a senior staff specialist and professor in intensive care at Rigshospitalet, University of Copenhagen and an honorary professor of the George Institute in Sydney. His focus is on clinical research in critically ill patients and he chairs the Danish national Centre for Research in Intensive Care and the Scandinavian Critical Care Trials Group. He was the chair of three land-mark trials, the 6S, TRISS and CLASSIC trials, the results of which has improved the fluid and transfusion therapy of patients with sepsis. His ongoing research continues along this track testing frequent interventions given to critically ill patient for which there are doubts about the balance between benefit and harm. The ongoing clinical research programs include the use of oxygen, anti-psychotics, IV fluids, anti-arrhythmics, antibiotics and steroids in intensive care patients.

Twitter:  @AndersPerner

Matthew Semler

Matthew Semler

Chief Investigator PILOT Trial

Matthew W. Semler MD, MSc is an Assistant Professor of Medicine and Biomedical Informatics in the Division of Allergy, Pulmonary, and Critical Care Medicine at Vanderbilt University. Dr. Semler is a critical care physician and Associate Director of the Medical Intensive Care Unit at Vanderbilt University. Dr. Semler’s federally-funded research identifies non-patient-centered variation in current clinical practice, embeds pragmatic randomized trials into clinical care to understand which treatments produce the best outcomes for which patients, and implements the results into practice. Randomized trials he has helped lead, including six published in the New England Journal of Medicine or JAMA, have challenged longstanding dogma around common practices in fluid management, airway management, and respiratory support. Dr. Semler serves as Chair of the Steering Committee for the Pragmatic Critical Care Research Group, co-director of the Inpatient Division of the Learning Healthcare System at Vanderbilt University, and a member of the protocol committee for trials within the NHLBI PETAL Network.

Pierre Bouzat

Pierre Bouzat

Chief Investigator PROCOAG Trial

Pierre Bouzat is the head of the Department of Anesthesiology and Intensive Care at the Grenoble Alps University Hospital Grenoble, France. The Grenoble University Hospital is located in the French Alps and is one the biggest trauma centers in France. Pierre Bouzat is also a full professor of anesthesiology and intensive care at the Grenoble Alpes University.

He’s also a researcher at the Grenoble Neuroscience Institute. His main research domain is neuroscience and severe trauma, with a special focus on traumatic brain injury. He is the past chair of the scientific committee of the French Society of Anesthesiology and Intensive Care. With several colleagues in the Northern French Alps, he is one of the founders of the TRENAU network (Trauma system of the Northern French Alps).
PubMed  |  Researchgate

Editorialists & Panellists


Diana Cimpoesu

Prof in Emergency Medicine, Lasi, Romania

Diana Cimpoesu is Professor in Emergency Medicine at the University of Medicine and Pharmacy (UMF) "Gr. T. Popa" Iaşi, Romania. Previously, she has served as the President of the Emergency Medicine Commission at the Ministry of Health, Romania, the President of the Emergency Medicine Commission of the Romanian College of Physicians and has been Chair of the Pre-Hospital Section of the Europen Society of Emergency Medicine.

Prof Cimpoesu has authored 14 books and 50 book chapters, 90 peer reviewed articles and has presented at over 120 national and international confereces as an invited speaker.

Fiona Kelly

Fiona Kelly is a consultant in anaesthesia and intensive care medicine in Bath. She was airway lead in Bath for eight years and co-led the introduction of videolaryngoscopes for all intubations with Professor Tim Cook in 2017.

Fiona was chair of the Difficult Airway Society and Association of Anaesthetists’ human factors guideline group, and a member of the Royal College of Anaesthetists’ short working party on unrecognised oesophageal intubation.

Fiona was faculty tutor for ICM and deputy training TPD for ICM in the Severn region. She also has an interest in recovery from potentially traumatic events and is a member of the Association of Anaesthetists’ wellbeing working party.

Twitter: @Fionafionakel

Dr Susan Rowell

Susan Rowell

Professor, University of Chicago

Susan Rowell MD, MBA, MCR, FACS is a specialist in Trauma Surgery and Surgical Critical Care. She completed her Surgical Critical Care Fellowship at Oregon Health & Science University followed by a fellowship in prehospital clinical trials with the Resuscitation Outcomes Consortium. While practicing trauma surgery at Oregon Health & Science University she earned a master’s degree in clinical research and completed a K-award in Emergency Care Research focusing on coagulation in traumatic brain injury. She was subsequently funded by both the National Institutes of Health and the Department of Defense to conduct the Prehospital TXA for TBI Trial that was published in JAMA which was a multinational trial that randomized patients in the prehospital setting to receive one of two doses of TXA or placebo. Based on these trial results, the Committee on Tactical Combat Casualty Care changed their guidelines to recommend a 2-gram TXA bolus to patients with TBI worldwide.

Dr. Rowell has also been funded by the NIH to examine circulating biomarkers of brain injury in patients with severe TBI and has served as a consultant to the Neurologic Emergencies Treatment Trials group as well as other major clinical trials. Dr. Rowell is currently Director of the Surgical Intensive Care Unit and Surgical Critical Care Fellowship Program at the University of Chicago and is leading the effort to develop a Neurotrauma Institute focusing on penetrating brain injury at the University of Chicago. Dr. Rowell currently serves as a member of the editorial board for the Journal of Trauma and is involved in the development of many of the national guidelines for the treatment of traumatically injured patients.

Twitter:  @SusanRowellMD

Ellen O'Sullivan

Professor, Trinity College Dublin

Ellen O'Sullivan trained in anaesthesiology and intensive care in UK and USA and is now a Consultant Anaesthesiologist at St James’s Hospital Dublin, Ireland affiliated to Trinity College Dublin. She specializes in airway management and is Director of the Fellowship in Advanced Airway Management and Simulation. She is Past President of the Difficult Airway Society, DAS, and was appointed DAS Professor of Anaesthesia & Airway Management.

Prof O’Sullivan is Past President of the College of Anaesthesiologists of Ireland and is now Airway Lead Advisor to the College & runs the CAI national airway training. She has a substantial portfolio of clinically relevant research and has co-authored more than 140 scientific papers (H-Index 22), books, website modules etc Clinically she has developed a worldwide reputation in airway management and lectures and teaches workshops internationally. She was a member of the ASA Task Force on Management of the Difficult Airway and also sits on the Project for Universal Airway Guidelines Group (PUMA) guideline group. She is an Executive Director of WAAM (World Alliance for Airway Management) and co-chaired the World Airway Meeting, WAMM1, in Dublin 2015 and WAMM2 in Amsterdam 2019. A particular interest of Prof O’ Sullivan’s is Global Anaesthesia and supporting education and training in low & middle income countries. This has led to her involvement in a number of projects in Malawi & Uganda including the Global Capnography Project (GCAP).

Twitter:  @ProfEllenO

Stephen Bernard

Stephen Bernard

Professor Stephen Bernard is an Intensive Care Specialist at The Alfred and the Victorian Heart Hospitals, Director of Intensive Care at Knox Private Hospital and Medical Advisor to Ambulance Victoria. He is an Adjunct Professor in the Department of Epidemiology and Preventive Medicine at Monash University.

He has been a Chief Investigator in numerous clinical trials funded by the Australian National Health and Medical Research Council. In out-of-hospital cardiac arrest patients, the “EXACT” trial tested the reduction of oxygen early after resuscitation, “TAME” tested therapeutic hypercapnia after admission to ICU and “RINSE” tested pre-hospital therapeutic hypothermia. In trauma patients, “PATCH” tested the role of tranexamic acid in patients with suspected bleeding. In patients with severe TBI, “POLAR” tested early therapeutic hypothermia and the “RSI” trial tested paramedic rapid sequence intubation. The “ICED” trial tested early therapeutic hypothermia in patients with complete spinal cord injury.

Twitter: @AmbVicMedic

John Holcomb

John Bradley Holcomb received his M.D. from the University of Arkansas Medical School in 1985. He entered the U.S. Army in 1985, and completed his general surgery training in 1991. Dr Holcomb then deployed with the Joint Special Operations Command for the next decade and also led one of the first Military Civilian Partnerships from 1999-2001. From 2002 to 2008, COL Holcomb was the Commander of the U.S. Army Institute of Surgical Research and Trauma Consultant for the Army Surgeon General. Over the years he has multiple combat deployments. He is a three time recipient of the Army’s Greatest Invention award, the ‘A” Designator in Military Medicine, the Order of Military Medical Merit and the Department of the Army Research and Development Achievement Award for Leadership Excellence. COL Holcomb retired from active duty in 2008 and received the Lifetime Achievement Award in Trauma Resuscitation Science from the American Heart Association, the United States Special Operations Command Medal, and the Service award from the American College of Surgery. He has been a member of the Committee on Tactical Combat Casualty Care since 2001.

From 2008-2019 Dr. Holcomb worked at UT Health, Houston Texas, as a Professor of Surgery. In 2016 he received the MAJ Jonathan Letterman award from the National Museum of Civil War Medicine an in 2022 the Robert Danis Prize from International Surgical Society. In 2019 Dr Holcomb joined the University of Alabama, Birmingham as a Professor of Surgery. Dr. Holcomb is actively involved in clinical medicine, education, research, entrepreneurship and is a founder and Co-CEO of a health IT company (Decisio Health). He reviews papers for 44 journals, has published > 700 peer reviewed articles, consults with several companies and serves on multiple boards. Dr. Holcomb and his wife, Dr. Kelly Wirfel were married in 1998 and have 2 children.

Kathryn Maitland

Kathryn Maitland is Professor of Paediatrics at Imperial College, London and is based full-time in East Africa, where she leads a research group whose portfolio includes severe malaria, bacterial sepsis and severe malnutrition in children. Her team conducted the largest trial in critically children ever undertaken in Africa (FEAST trial) examining fluid resuscitation strategies in children with severe febrile illness, showing that fluid boluses increased mortality. She has also lead the landmark TRACT trial, investigating transfusion and other treatment strategies in 3800 African children severe life-threatening anaemia, and the COAST trial (Children Oxygenation Administration Strategies Trial) examining the optimum oxygen saturation threshold for which oxygen should be targeted and how best to administer oxygen, by high flow or low flow, in 4200 severely ill African children. In recognition of her contribution to medical research and healthcare she was recently elected to Fellowship of the Academy of Medical Sciences.

Twitter:  @KathMaitland

Flavio Machado

Flavia Machado

Professor, Federal University of São Paulo, Brazil

Flavia Machado is professor and head of the Intensive Care Session of Anesthesiology, Pain and Intensive Care Department at the Federal University of São Paulo in Brazil. Machado is board certified in internal medicine, infectious diseases and critical care.
Dr. Machado is one of the founders of the Latin America Sepsis Institute–LASI. She was the president between 2008-2011, vice president between 2012-2015 and is currently its CEO. LASI is devoted to awareness raising, quality improvement and coordination of multicenter studies in sepsis field.


She is part of the executive board of the Global Sepsis Alliance and the executive committee for the World Sepsis Day. She serves on the 2012 and 2016 board of the Surviving Sepsis Campaign International Guidelines. She integrates the International Sepsis Forum (ISF) council since 2014. She is also a member of both the Executive and Scientific Committee of the Brazilian Research in Intensive Care Network-BRICNET.

Twitter: @FlaviaSepsis

Fernando Zampieri

Fernando Zampieri

Researcher and intensivist, Research Institute HCor-Hospital do Coração, Sao Paulo, Brazil

Dr Fernando Zampieri is a researcher and critical care physician at the Albert Einstein Hospital, Sao Paulo, Brazil. He graduated at University of São Paulo, Brazil in 2010 and was awarded a PhD in Medical Sciences by University of São Paulo in 2017.  Fernando is Adjunct Professor at  the Center for Epidemiological Research in the University of Southern Denmark (SDU), Odense, Denmark, Research Coordinator at HCor Research Institute in São Paulo, Brazil. He has acted as principal investigator of both large pragmatic clinical trials and observational studies in critical medicine.

Twitter:  @f_g_zampieri

Bala Venkatesh

Bala Venkatesh

Professor of Intensive Care Medicine, University of Queensland, Brisbane, Australia

Bala Venkatesh is Director of Intensive Care at the Wesley Hospital, Pre-Eminent Specialist in Intensive Care Medicine at the Princess Alexandra Hospital, Brisbane, Professor of Intensive Care Medicine at the University of Queensland, and at the University of New South Wales, and Professorial Fellow at the George Institute for Global Health, Sydney Australia. He has completed Fellowship training in Internal Medicine, Anaesthesia and Intensive Care Medicine. He then undertook a research degree from the University of Birmingham, UK which led to the award of an MD. He pioneered the development of a continuous blood gas monitoring system which reached clinical application. He served as the President for the College of Intensive Care Medicine of Australia and New Zealand between 2014-2016. He was the Principal Investigator of the NHMRC funded multi-center international ADRENAL trial which is largest septic shock trial to date. This was published in the New England Journal of Medicine. His research interests include glucocorticoid physiology in critical illness including the development of the idea of the "sick euadrenal state, sepsis, and vitamin D in critical illness. He has published more than 180 papers, and 40 book chapters internationally.

Kathy Rowan

Kathy Rowan

Director, NIHR Health and Social Care Delivery Research Programme, & Director, ICNARC, London, England

Professor Kathy Rowan is the Director of the NIHR Health and Social Care Delivery Research Programme, Director of the Intensive Care National Audit & Research Centre (ICNARC), Honorary Professor at the London School of Hygiene & Tropical Medicine and Adjunct Professor (Research) at Monash University, Australia.

In 1994, following her PhD from the University of Oxford, Professor Rowan founded ICNARC, an independent, not-for-profit, scientific organisation to facilitate improvements in the structure, process, outcomes and experiences of critical care - for patients and for those who care for them. ICNARC manages a broad programme of clinical audit and clinical/health services research, nationally and internationally.

Professor Rowan was awarded the Humphry Davy Medal by the UK Royal College of Anaesthetists (2004), completed a Harkness Fellowship (2005), received the President’s Prize with honorary life membership of the UK Intensive Care Society (2019) and Officer of the Most Excellent Order of the British Empire (Queen’s Birthday Honours’ List 2021) for services to research and intensive care.

Twitter:  @KathyRowan101

Lars Wiuff Andersen

Lars W. Andersen is a clinician and researcher interested in patients with acute and critical illness and with a special focus on patients with cardiac arrest. His research spans animal experiments, observational studies, clinical trials, and systematic reviews. He is currently the principal investigator on multiple clinical trials, including in patients with cardiac arrest in- or out-of-hospital. He is a member of the Advanced Life Support task force at the International Liaison Committee on Resuscitation. He is a statistical reviewer at JAMA and an editorial board member at Resuscitation.

Twitter: @LarsWAndersen1

Danny McAuley

Danny McAuley

Professor in Intensive Care Medicine, Queen's University Belfast, Northern Ireland

Danny McAuley is a Consultant and Professor in Intensive Care Medicine at the Regional Intensive Care Unit at the Royal Victoria Hospital and Queen’s University of Belfast. He undertook his training in Belfast, Birmingham, London and San Francisco. He is Programme Director for the MRC/NIHR Efficacy and Mechanism Evaluation (EME) programme and Co-Director of Research for the UK Intensive Care Society. He has several research interests including Acute Respiratory Distress Syndrome and clinical trials. He is the co-chief investigator for the RECOVERY-RS trial

Twitter: @dfmcauley

Bronwen Connolly

Bronwen Connolly

Senior Lecturer in Critical Care, Queen's University Belfast, Northern Ireland

Dr Bronwen Connolly is a critical care physiotherapist, and Senior Lecturer in Critical Care at Queen’s University Belfast, UK. The recipient of three previous NIHR Fellowships (Doctoral, Postdoctoral, Clinical Trials), her research interests focus on acute respiratory and rehabilitation physiotherapy, the recovery, long-term outcome, and survivorship of post critical illness patients, and clinical trial methodology around complex rehabilitation interventions. Her current work includes leading a multiprofessional team developing a randomized controlled trial investigating the effectiveness of mucoactive drugs in acute respiratory failure, and the development of a core outcome set for trials of physical rehabilitation in critical illness. Bronwen is involved with a number of major national and international research organisations including the NIHR Critical Care Specialty Group, the UK Critical Care Research Group, and the International Forum for Acute Care Trialists.

Twitter:  @bronwenconnolly

Paul Mouncey

Paul Mouncey

Head of Research at ICNARC

Catriona Kelly

Catriona Kelly

Neurointensivist & Neuroanaesthetist, Beaumont Hospital, Dublin, Ireland

Catriona is a neurointensivist and neuroanaesthetist in Beaumont Hospital, Dublin. Originally from Belfast, Catriona went to medical school in Dundee, undertook her post-graduate training in Northern Ireland and a fellowship in neurointensive care and neuroanaesthesia in Toronto. After working for several years in Belfast, Catriona moved to Dublin in 2021. She is a member of the Critical Care Reviews Meeting organising committee.

Twitter: @kelly1_catriona

Journal Editors


Howard Bauchner

Howard Bauchner

Editor-in-Chief JAMA, 2011 - 2021

Howard Bauchner, MD served as the 16th Editor in Chief of JAMA and the JAMA Network between 2011 and 2021.  Prior to coming to JAMA, Howard was a Professor of Pediatrics and Public Health at Boston University School of Medicine and Editor in Chief of Archives of Disease in Childhood (2003-2011).  At BUSM he was Vice-Chair of Research for the Department of Pediatrics and Chief, Division of General Pediatrics.  He is a member of the National Academy of Medicine and an honorary fellow of the Royal College of Paediatrics and Child Health.  He is currently on faculty at BUSM.

At JAMA, Howard focused on publishing important and novel research articles including randomized clinical trials, opinion pieces, and special communications, improving and expanding clinical content, using electronic/digital approaches to enhance communication, and ensuring a commitment to innovation.  During his tenure followers on social media increased from ~13,000 to ~1,200,000 and the electronic table of contents was distributed to over 1,000,000 individuals each week.  In print, via eTOC, and social media content published by JAMA reached over 1.5M physicians worldwide.  Views (PDF and HTML) increased from 10M in 2011 to over 100M in 2020 (50% from outside the U.S.).   Podcast downloads increased from 300,000 in 2014 to 6M and videos were viewed more than 16M times in 2020.  The print journals were redesigned for the first time in over 20 years and the website updated twice.  All 9 of the specialty journals were renamed (Archives of Pediatrics became JAMA Pediatrics, etc.), 4 new journals were launched – JAMA Oncology (2015), JAMA Cardiology (2016), and JAMA Network Open (2018); and JAMA Health Forum (2020/2021).  Howard authored and conducted over 200 editorials and podcasts (including live-stream events) discussing issues such as open-science (data-sharing, pre-print servers, open access), conflict of interest, diversity in medicine, the interpretation of randomized clinical trials, mentoring, maintaining editorial standards during a pandemic, the language and reporting of race and ethnicity, scientific misconduct, authorship and team science, and numerous health policy issues, including healthcare as a right, waste in medicine, pharmaceutical and the cost of health care, health care disparities, and race, racism, and poverty in medicine.

Darren Taichman

Darren Taichman

Deputy Editor NEJM
Derek Angus

Derek Angus

Senior Editor, JAMA

Prof Derek Angus is Chair of the Department of Critical Care Medicine, UPMC and University of Pittsburgh School of Medicine. oversees UPMC's clinical research, implementation science and data analytics, with a particular emphasis on UPMC's learning health system initiatives. He also is associate vice chancellor for Healthcare Innovation at the University of Pittsburgh Schools of the Health Sciences. He is a distinguished professor and holds the Mitchell P. Fink Endowed Chair in Critical Care Medicine at the University of Pittsburgh, with secondary appointments in Medicine, Health Policy and Management, and Clinical and Translational Science. Since 2008, Dr. Angus has served as chair of the Department of Critical Care Medicine. Since 2015, he also has been the physician director of the UPMC ICU Service Center, responsible for the provision of ICU services across the 30-plus hospital system.

Dr. Angus is a world-renowned clinical, translational and health services researcher. His research interests include clinical, epidemiologic and translational studies of sepsis, pneumonia and multisystem organ failure as well as health services research of the organization and delivery of critical care services. Dr. Angus is a leader in developing and evaluating approaches to facilitate smarter decision making and faster learning in health care, including novel Bayesian adaptive platform trial designs, the application of machine learning to large-scale data, and the use of behavioral economics and decision psychology to support optimal decision making. He has led numerous NIH-funded multicenter studies, written several hundred papers and is a Clarivate Highly Cited Researcher.

Christopher Seymour

Christopher Seymour

Associate Editor for Critical Care, JAMA

Dr. Seymour is an Associate Professor in the Departments of Critical Care, Emergency Medicine, and Clinical and Translational Science at the University of Pittsburgh School of Medicine. Over the past 10 years, his research program has focused on clinical and translational studies involving sepsis, biomarkers, and large electronic health record databases. Dr. Seymour completed his NIGMS Career Development Award (K23), mentored by Dr. Derek Angus, titled “Prehospital identification of high-risk sepsis.” This successful award led to funding of a NIH/NIGMS R35 ESI-Merit Investigator Research Award, “Sepsis endotypes during emergency care.” He is Director of the Clinical and Translational Science Program in the Department of Critical Care Medicine, member of the International Sepsis Forum (ISF), and Associate Editor for Critical Care at JAMA. His research has been published in the New England Journal of Medicine, JAMA, and The Lancet, among others.

Twitter:  @seymoc

Statisticians


Marion Campbell

Vice-Principal (Research), University of Aberdeen, & Professor of Health Services Research

Marion Campbell is Vice-Principal (Research) for the University of Aberdeen and Professor of Health Services Research in the Health Services Research Unit (HSRU).   Marion is a medical statistician and clinical trialist. Her main research interests are in the design, conduct and analysis of clinical trials, especially complex trial design and the design and conduct of surgical and device trials.  She has published widely on clinical trials methodology, including on cluster randomised trials, design of trials of non-pharmacological interventions, pragmatic trials and trials reporting.  She has served on many national and international funding agencies and committees and is an elected Fellow of the Royal Society of Edinburgh, the Faculty of Public Health and the International Society for Clinical Trials.

Marion graduated with an honours degree in Statistics from the University of Aberdeen and subsequently gained an MSc in Statistics and PhD in Public Health.  Following early career appointments within the National Health Service in the fields of Operational Research and Statistics of Medical Audit, she joined the Health Services Research Unit in 1993.  She became Director of the Unit in 2007 - a position she held until the end of 2015, when she became Dean of Research for Life Sciences and Medicine.  She took up the role of Vice-Principal (Research) in October 2017.  HSRU remains her academic base.

Twitter:  @MarionKCampbell

Andrew Althouse

Andrew Althouse

Statistical Genius

He has a productive record as a collaborative statistician, with over 100 published manuscripts, and he has presented at national meetings of the American Diabetes Association, American Heart Association, American Statistical Association, and the Society for General Internal Medicine.

He is currently Statistical Editor for Circulation: Cardiovascular Interventions as well as a Deputy Statistical Editor for Journal of Thoracic and Cardiovascular Surgery, and serves as Vice Chair of the American Heart Association Statistics Task Force.

Twitter:  @ADAlthousePhD

Victoria Cornelius

Victoria Cornelius

Professor of Medical Statistics, Imperial College, London

Victoria Cornelius is a Professor in Medical Statistics and Trial Methodology and Director of Imperial Clinical Trials Unit. Her work in trials includes evaluating drug and complex interventions developing approaches that promote statistical efficiency in both Bayesian and frequentist frameworks. Her statistical methods research is in the use of time-to-event signal detection methods to identify adverse drug reactions, and co-leads the NIHR MRC TMRP specialist research group to improve the analysis of harm outcomes in randomised controlled trials.

Twitter:  @VR_Cornelius

David Harrison

David Harrison

Senior Statistician at the Intensive Care National Audit & Research Centre

Prof David Harrison graduated from the University of Cambridge with an MA in mathematics and a PhD in mathematical modelling of disease progression. He has worked for ICNARC since 2002. David is a Fellow of the Royal Statistical Society and an Honorary Professor in the Medical Statistics Unit of the London School of Hygiene & Tropical Medicine.

Twitter: @DavidHarrison80

John Norrie

John Norrie

Professor of Medical Statistics and Trial Methodology, University of Edinburgh, Scotland

Professor John Norrie is Professor of Medical Statistics and Trial Methodology, Director of the Edinburgh Clinical Trials Unit and Co-Head of the Centre for Population Health Sciences at the University of Edinburgh.  He specialises in genetic, molecular and population health sciences.

Twitter: @john_norrie

Roger Lewis

Roger Lewis

Dr. Lewis received his PhD in Biophysics and his MD from Stanford University. He is a Senior Physician in the Los Angeles County Department of Health Services, Professor of Emergency Medicine at the David Geffen School of Medicine at UCLA, and a Senior Medical Scientist at Berry Consultants, LLC, a group that specializes in innovative clinical trial design. Dr. Lewis is a statistical editor for JAMA and an editor of the JAMA series entitled “JAMA Guides to Statistics and Methods.” His expertise centers on adaptive and Bayesian clinical trials, including platform trials; general clinical research methodology; data and safety monitoring boards, and the oversight of clinical trials. Dr. Lewis was elected to membership in the National Academy of Medicine in 2009.

Dr. Lewis is the former Chair of the Department of Emergency Medicine at Harbor-UCLA Medical Center. He has previously served as a member of the Blood Products Advisory Committee of the US Food and Drug Administration, Center for Biologics Evaluation and Research (CBER), the Medicare Evidence Development & Coverage Advisory Committee of the Centers for Medicare & Medicaid Services, and on multiple consensus committees of the National Academy of Medicine. He has chaired data and safety monitoring boards (DSMBs) for numerous federally funded, industry-sponsored, and multinational clinical trials. Dr. Lewis has served as a content reviewer for many other peer reviewed journals. He has authored or coauthored over 270 original research publications, reviews, editorials, and chapters.

Dr. Lewis has served as a grant reviewer for the Agency for Healthcare Research and Quality (AHRQ), the Canadian Institutes of Health Research (CIHR), the Centers for Disease Control and Prevention (CDC), the UK Medical Research Council (MRC), the National Cancer Institute of France, the National Institutes of Health (NIH), the Patient Centered Outcomes Research Institute (PCORI), and foundations.

During the US COVID-19 epidemic, Dr. Lewis served as the Director of Covid-19 Demand Modeling for the Los Angeles County Department of Health Services, leading a multidisciplinary team developing epidemiological prediction models to aid in hospital preparedness and response.

Dr. Lewis is a Past President of the Society for Academic Emergency Medicine (SAEM) and served on the Board of Directors for the Society for Clinical Trials. He is a fellow of the American College of Emergency Physicians, the American Statistical Association, and the Society for Clinical Trials.

Twitter:  @RogerJLewis

Disseminating Evidence for over a Decade


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