Topic of the Week February 29th to March 6th 2016 Sepsis Monday Gould. Antibiotics: from prehistory to the present day. J Antimicrob Chemother 2016;71(3):572-575 Tuesday Czaplewski. Alternatives to antibiotics—a pipeline portfolio review. Lancet Infect Dis 2016;epublished January 12th Wednesday Mallat. Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock. World J Crit Care Med 2016;5(1):47-56 Thursday Bassetti. Treatment of Gram-negative pneumonia in the critical care setting: is the beta-lactam antibiotic backbone broken beyond repair? Critical Care 2016;20:19 Friday Marik. A rational approach to fluid therapy in sepsis. Br J Anaesth 2016;116(3):339-349 Saturday Angus. A Framework for the Development and Interpretation of Different Sepsis Definitions and Clinical Criteria. Crit Care Med 2016;44(3):e113–e121 Sunday Seymour. Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria. Crit Care Med 2016;44(3):e122–e130