CCR-Newsletter-BannerNewsletter 316  |  December 31st 2017

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ADRENAL Trial Result CCR315

 

Happy New Year!

Welcome to the 316th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

It's now less than 3 weeks to the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want answered - should I change my practice based on this trial? This time, for the first time, Critical Care Reviews will host a major trial result. And not just any trial result! We are proud to have, from Brisbane, Australia, Prof Bala Venkatesh presenting the first results of the ANZICS' landmark ADRENAL trial, examining hydrocortisone in septic shock, in the biggest sepsis trial ever undertaken. After the results of ADRENAL have been presented, Prof Kathy Rowan will deliver a 15 minute editorial, followed by a 30 minute panel discussion, including three ADRENAL investigators (Prof Bala Venkatesh, Prof Anders Perner & Prof Simon Finfer), Prof Kathy Rowan, an expert trialist and CI of ProMISe, Prof Karin Amrein, an endocrinologist/intensivist/trialist and Prof Anthony Gordon, who also looked at steroids in sepsis as part of his VANISH trial. Prof Venkatesh will complete the session with a talk dicussing the administration of the ADRENAL trial, including the various issues they faced. If you can't make it, don't worry as the entire ADRENAL session will be live streamed for free, starting at 9am GMT. All the other talks will be recorded and released later for free viewing as usual.

In addition, as usual we have a fantastic range of chief investigators and investigators to discuss their fascinating trials. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in vasodilatory shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial BREATHE, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART trial, investigating alveolar recruitment in ARDS, to be presented by Prof Alexandre Cavalcanti (São Paulo, Brazil). 

We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World".

A new addition to the Critical Care Reviews Meeting format is an incredible editorial team of Prof Kathy Rowan (London), Prof Karin Amrein (Graz), Prof Anders Perner (Copenhagen) and Prof Simon Finfer (Sydney). These noted trialists will provide expert analysis on the major trials being presented.

We sold out #CCR17 and had to turn people away. In previous years 60 to 70% of delegates registered in January. By New Year's Eve, we are over 80% sold out, despite an enhanced capacity, so, if you intend on coming, be warned - the usual rush is about to commence! Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......

Continuing our focus on the trials being presented at #CCR18, we now turn to ADRENAL for this week's Topic of the Week and look at some of the previous trials in this field, starting with the CORTICUS trial in tomorrow's Paper of the Day.

Research

Review Articles

Neurological

Circulatory

Respiratory

Renal

Haematological

Sepsis

Perioperative

Miscellaneous

Meetings

September Announcement 060917 v1

It's now just 2 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in septic shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART Trial. Prof Alexandre Biasi Cavalcanti (São Paulo) will explain this Brazilian investigation testing alveolar recruitment in ARDS.

We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World"

We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......

Marina Bay Singapore SeanLoh WO

"Fancy attending a leading intensive care medicine conference with worldwide experts in one of Asia Pacific’s most vibrant countries? At SG ANZICS 2018 in Singapore, you can meet renowned experts from all parts of the world at their plenary sessions, breakfast and lunch symposia and interactive conference sessions. Choose from our 10 preconference critical care workshops on offer and also showcase your poster to make an impression on international attendees.

SG ANZICS is an annual intensive care meeting jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS). In 2017, we had 1200 attendees from more than 35 different countries. We are also proud to announce that we have awarded 30 Education Grants to low and lower-middle income countries and affirm our commitment to improve critical care in developing Asia-Pacific countries.

Our 5th meeting is scheduled for 17-21 May 2018 in Suntec Convention Centre. It promises to be better than ever! Timothy Buchman, Hayley Gershengorn, Anthony Gordon, Michael Pinsky, David Pilcher and Francesca Rubulotta are among a list of illustrious speakers confirmed for the conference.  Do keep your dates free and block your calendars.  Visit http://sg-anzics.com to find out more!"

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

 

I hope you find these links useful.


Until next week

Rob

Supported by the Health Research Board

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