Welcome to the 311th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's newsletter are two randomised controlled trials on high-volume hemofiltration in adult burn patients with septic shock and AKI & the effect of earplugs and eye mask on sleep in critically ill patients; a meta analysis on renal replacement therapy intensity for AKI; an observational study reporting outcomes after VV ECMO referral for respiratory failure; narrative reviews on the TAME cardiac arrest trial, perioperative cardiac arrest and cardiac output monitoring validation studies; as well as editorials on 48-hour targeted temperature management & iatrogenic hemodilution; plus a commentariy on complications of regional citrate anticoagulation.
There are also two series of reviews articles, from the BJA on "Landmarks in UK Anaesthesia", and from Nephron on "Acute Kidney Injury". If you only have time to read one article this week, check out this excellent overview of Free Open Access Medical Education (FOAMed) by Chris Nickson, one of the main people responsible for this outstanding movement.
Continuing our theme of focusing on the main papers to be presented and discussed at #CCR18, this week's Topic of the Week is the ATHOS-3 trial, investigating angiotension II in vasodilatory shock, and starting with the trial itself in tomorrow's Paper of the Day.
The latest news on the Critical Care Reviews Meeting 2018 is the addition of Prof Simon Finfer (Sydney) to the editorial team, which includes Prof Kathy Rowan (London), Prof Karin Amrein (Graz), and Prof Anders Perner (Copenhagen). The best crtical care trials of 2017 will be subjected to some of the most incisive thinkers in the speciality. If you want to understand the methodological strengths and weaknesses of the evidence which underpins our practice, this is the meeting for you. Hopefully, we might have one little more surprise to announce in the next few weeks also.....
- Full Text: Chung. High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial (RESCUE). Critical Care 2017;21:289
- Full Text: Demoule. Impact of earplugs and eye mask on sleep in critically ill patients: a prospective randomized study. Critical Care 2017;21:284
- Abstract: Weinberg. Plasma-Lyte 148 vs. Hartmann’s solution for cardiopulmonary bypass pump prime: a prospective double-blind randomized trial. Perfusion 2017;epublished November 16th
- Abstract: Wang. Renal replacement therapy intensity for acute kidney injury and recovery to dialysis independence: a systematic review and individual patient data meta-analysis. Nephrology Dialysis Transplantation 2017;epublished November 23rd
- Full Text: McNally. Vitamin D deficiency in critically ill children: a systematic review and meta-analysis. Critical Care 2017;21:287
- Full Text: Jiang. Video laryngoscopy does not improve the intubation outcomes in emergency and critical patients – a systematic review and meta-analysis of randomized controlled trials. Critical Care 2017;21:288
- Abstract: Cooke. Volume responsiveness assessed by passive leg raising and a fluid challenge: a critical review focused on mean systemic filling pressure. Anaesthesia 2017;epublished November 24th
- Full Text: Ni. Can high-flow nasal cannula reduce the rate of reintubation in adult patients after extubation? A meta-analysis. BMC Pulmonary Medicine 2017;17:142
- Full Text: Poole. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ 2017;359:j5024
- Abstract: Gillon. Acceptance and transfer to a regional severe respiratory failure and veno-venous extracorporeal membrane oxygenation (ECMO) service: predictors and outcomes. Anaesthesia 2017;epublished November 23rd
- Abstract: O'Brien. Higher versus Lower Continuous Renal Replacement Therapy Intensity in Critically ill Patients with Liver Dysfunction. Blood Purif 2017;45(1-3):36-43
- Abstract: Arabi. Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome. Am J Respir Crit Care Med 2017;epublished November 21st
- Abstract: Chapman. Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome. JAMA 2017;318(19):1913-1924
- Hajibandeh. Neuromuscular electrical stimulation for the prevention of venous thromboembolism. Cochrane Database of Systematic Reviews 2017, Issue 11. Art. No.: CD011764
- De Orange. Cuffed versus uncuffed endotracheal tubes for general anaesthesia in children aged eight years and under. Cochrane Database of Systematic Reviews 2017, Issue 11. Art. No.: CD011954
- 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 2017;epublished November 13th
- Eastwood. TAME cardiac arrest: A phase III multicenter randomized trial of targeted therapeutic mild hypercapnia after resuscitated cardiac arrest. Saudi Crit Care J 2017;1, Suppl S2:10-3
- Lorente. Biomarkers Associated with the Outcome of Traumatic Brain Injury Patients. Brain Sci 2017;7(11):142
- Hinkelbein. Perioperative cardiac arrest in the operating room environment: a review of the literature. Minerva Anestesiologica 2017;83(11):1190-8
- Phillips. Stroke Volume Monitoring: Novel Continuous Wave Doppler Parameters, Algorithms and Advanced Noninvasive Haemodynamic Concepts. Current Anesthesiology Reports 2017;7(4):387–398
- Odor. Cardiac Output Monitoring: Validation Studies–how Results Should be Presented. Current Anesthesiology Reports 2017;7(4):410–415
- Ten Berg. Optimal duration of dual antiplatelet therapy after percutaneous coronary intervention or after acute coronary syndrome. Netherlands Heart Journal 2017;25(12):655–663
- Biswas. The role of bedside point-of-care ultrasound evaluation of the lung in the critically ill patient. J Emerg Crit Care Med 2017;1:34
- van der Voort. How to prevent and treat gastrointestinal bleeding in the critically ill patient: a pathophysiological approach. J Emerg Crit Care Med 2017;1:35
- West. Prehabilitation and Nutritional Support to Improve Perioperative Outcomes. Current Anesthesiology Reports 2017;7(4):340–349
- Liew. The Endothelial Glycocalyx in Health and Kidney Disease: Rising Star or False Dawn?. Nephrology 2017;epublished November 16th
- Donati. Sodium Prescription in the Prevention of Intradialytic Hypotension: New Insights into an Old Concept? Blood Purif 2018;45:61-70
- Howell. Abdominal aortic aneurysm repair in the United Kingdom: an exemplar for the role of anaesthetists in perioperative medicine. Br J Anaesth 2017;119(suppl 1):i15-i22
- Foëx. Innovations in management of cardiac disease: drugs, treatment strategies and technology. Br J Anaesth 2017;119(suppl 1):i23–i33
- Richardson. Fit for surgery? Perspectives on preoperative exercise testing and training. Br J Anaesth 2017;119(suppl 1):i34–i43
- Sneyd. Thiopental to desflurane - an anaesthetic journey. Where are we going next? Br J Anaesth 2017;119(suppl 1):i44–i52
- Hunter. Reversal of residual neuromuscular block: complications associated with perioperative management of muscle relaxation. Br J Anaesth 2017;119(suppl 1):i53–i62
- MacDonald. Are we close to the ideal intravenous fluid? Br J Anaesth 2017;119(suppl 1):i63–i71
- Ashrafian. The evolution of robotic surgery: surgical and anaesthetic aspects. Br J Anaesth 2017;119(suppl 1):i72–i84
- Montgomery. Critical care at the end of life: balancing technology with compassion and agreeing when to stop. Br J Anaesth 2017;119(suppl 1):i85–i89
- McCrossan. Demands and requests for ‘inappropriate’ or ‘inadvisable’ treatments at the end of life: what do you do at 2 o’clock in the morning when …? Br J Anaesth 2017;119(suppl 1):i90–i98
- Cooper. The future United Kingdom anaesthetic workforce: training, education, and role boundaries for anaesthetists and others. Br J Anaesth 2017;119(suppl 1):i99–i105
- Higham. To err is human: use of simulation to enhance training and patient safety in anaesthesia. Br J Anaesth 2017;119(suppl 1):i106–i114
- Needham. Postoperative cognitive dysfunction and dementia: what we need to know and do. Br J Anaesth 2017;119(suppl 1):i115–i125
- Craven.Managing anaesthetic provision for global disasters. Br J Anaesth 2017;119(suppl 1):i126–i134
- Woolley. Global lessons: developing military trauma care and lessons for civilian practice. Br J Anaesth 2017;119(suppl 1):i135–i142
- Hodkinson. An overview of space medicine. Br J Anaesth 2017;119(suppl 1):i143–i153
- McNarry. The evolution of airway management – new concepts and conflicts with traditional practice. Br J Anaesth 2017;119(suppl 1):i154–i166
- Weir. Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics. Br J Anaesth 2017;119(suppl 1):i167–i175
- Poyan. PPARγ-Coactivator-1α, Nicotinamide Adenine Dinucleotide and Renal Stress Resistance. Nephron 2017;137:253–255
- Nangaku. Epigenetic Changes in the Acute Kidney Injury-to-Chronic Kidney Disease Transition. Nephron 2017;137:256–259
- Bullen. Renal Oxygenation and Hemodynamics in Kidney Injury. Nephron 2017;137:260–263
- Ó hAinmhire. Fibrotic Changes Mediating Acute Kidney Injury to Chronic Kidney Disease Transition. Nephron 2017;137:264–267
- Hukriede. Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury. Nephron 2017;137:268–272
- Dépret. A Role of Remote Organs Effect in Acute Kidney Injury Outcome. Nephron 2017;137:273–276
- Tanaka. Nonpharmacological, Biomechanical Approaches to Control Inflammation in Acute Kidney Injury. Nephron 2017;137:277–281
- Lee. Role of Immune Cells in Acute Kidney Injury and Repair. Nephron 2017;137:282–286
- Weller. Lymphocyte Function in Human Acute Kidney Injury. Nephron 2017;137:287–293
- Kwong. AKI Adjudication: Do We Need It. Nephron 2017;137:294–296
- Silver. The Economic Consequences of Acute Kidney Injury. Nephron 2017;137:297–301
- McIlroy. Standardized Renal Endpoints for Perioperative Clinical Trials: The Standardized Endpoints in Perioperative Medicine Initiative. Nephron 2017;137:302–305
- Wald. Care of the Acute Kidney Injury Survivor. Nephron 2017;137:306–309
- De Backer. Early goal directed therapy: where do we stand after the individual patient’s meta-analysis? J Emerg Crit Care Med 2017;1:36
- Lee. Is 48-hour targeted temperature management not superior to 24-hour targeted temperature management after out-of-hospital cardiac arrest in adults? Feasible but still inconclusive. J Emerg Crit Care Med 2017;1:37
- Wiles. Blood pressure in trauma resuscitation: ‘pop the clot’ vs. ‘drain the brain’?. Anaesthesia 2017;72:1448–1455
- Abdul-Aziz. Identifying "at-risk" patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections. Crit Care 2017;21(1):283
- Alsolamy. Knowledge gaps in the global practice of management of severe traumatic brain injury. Saudi Crit Care J 2017;1, Suppl S2:19-21
- del Pilar. Zika, Guillain–Barré and anesthesiology: A point of intersection between public health and clinical practice. Rev Colomb Anestesiol 2017;45:269-71
- Banerjee. Age, exercise, and the outcome of sepsis. Critical Care 2017;21:286
- Perel. Iatrogenic hemodilution: a possible cause for avoidable blood transfusions? Critical Care 2017;21:291
- Denehy. Critical illness, disability, and the road home. Intensive Care Med 2017;epublished November 22nd
- Schneider. Complications of regional citrate anticoagulation: accumulation or overload? Critical Care 2017;21:281
- Al-Dorzi. Pressure ulcers in critically III patients in Saudi Arabia: An opportunity for collaborative research on an ugly disease. Saudi Crit Care J 2017;1, Suppl S2:14-6
- Sevransky. Society of critical care medicine discovery: Collaborative critical care research network. Saudi Crit Care J 2017;1, Suppl S2:17-8
It's now less than 2 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in vasodilatory shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial BREATHE, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART trial, investigating alveolar recruitment in ARDS, to be presented by Prof Alexandre Cavalcanti (São Paulo, Brazil).
We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World". A new addition to the Critical Care Reviews Meeting format is an incredible editorial team of Prof Kathy Rowan (London), Prof Karin Amrein (Graz), Prof Anders Perner (Copenhagen) and Prof Simon Finfer (Sydney). These noted trialists will provide expert analysis on the major trials being presented.
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
Fancy attending a leading intensive care medicine conference with worldwide experts in one of Asia Pacific’s most vibrant countries? At SG ANZICS 2018 in Singapore, you can meet renowned experts from all parts of the world at their plenary sessions, breakfast and lunch symposia and interactive conference sessions. Choose from our 10 preconference critical care workshops on offer and also showcase your poster to make an impression on international attendees.
SG ANZICS is an annual intensive care meeting jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS). In 2017, we had 1200 attendees from more than 35 different countries. We are also proud to announce that we have awarded 30 Education Grants to low and lower-middle income countries and affirm our commitment to improve critical care in developing Asia-Pacific countries.
Our 5th meeting is scheduled for 17-21 May 2018 in Suntec Convention Centre. It promises to be better than ever! Timothy Buchman, Hayley Gershengorn, Anthony Gordon, Michael Pinsky, David Pilcher and Francesca Rubulotta are among a list of illustrious speakers confirmed for the conference. Do keep your dates free and block your calendars. Visit http://sg-anzics.com to find out more!
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board