Welcome to the 295th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. I've been very tight for time this week, so there's no introduction today. Enjoy your reading. The Topic of the Week will be posted tomorrow.
- Full Text: Wright. Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial. Thorax 2017;epublished August 5th
- Abstract: Sankar. Fluid Bolus Over 15-20 Versus 5-10 Minutes Each in the First Hour of Resuscitation in Children With Septic Shock: A Randomized Controlled Trial. Pediatr Crit Care Med 2017;epublished August 2nd
- Abstract: Lapergue. Effect of Endovascular Contact Aspiration vs Stent Retriever on Revascularization in Patients With Acute Ischemic Stroke and Large Vessel Occlusion. The ASTER Randomized Clinical Trial. JAMA 2017;318(5):443-452
- Full Text: Zhu. Could remifentanil reduce duration of mechanical ventilation in comparison with other opioids for mechanically ventilated patients? A systematic review and meta-analysis. Crit Care 2017;21(1):206
- Abstract: Carandini. Intensive versus standard lowering of blood pressure in the acute phase of intracranial haemorrhage: a systematic review and meta-analysis. Intern Emerg Med 2017;epublished August 3rd
- Abstract: Zhang. Efficacy of vasopressin-epinephrine compared to epinephrine alone for out of hospital cardiac arrest patients: A systematic review and meta-analysis. Am J Emerg Med 2017;epublished July 18th
- Full Text: Fevang. A systematic review and meta-analysis comparing mortality in pre-hospital tracheal intubation to emergency department intubation in trauma patients. Critical Care 2017;21:192
- Abstract: Jobs. Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome: a meta-analysis of randomised trials. Lancet 2017;epublished August 1st
- Full Text: Turon. Feasibility and safety of virtual-reality-based early neurocognitive stimulation in critically ill patients. Annals of Intensive Care 2017;7:81
- Full Text: Hraiech. How to reduce cisatracurium consumption in ARDS patients: the TOF-ARDS study. Annals of Intensive Care 2017;7:79
- Full Text: Schenkman. Muscle oxygenation as an indicator of shock severity in patients with suspected severe sepsis or septic shock. PLOS 2017;epublished August 3rd
- Abstract: Grasselli. Nosocomial Infections During Extracorporeal Membrane Oxygenation: Incidence, Etiology, and Impacton Patients' Outcome. Crit Care Med 2017;epublished August 2nd
- Full Text: Fernandez-Gonzalo. Feasibility and safety of virtual-reality-based early neurocognitive stimulation in critically ill patients. Ann Intensive Care 2017;7(1):81
- Full Text: Lippi. Scientist impact factor (SIF): a new metric for improving scientists’ evaluation? Ann Transl Med 2017;5(15):303
- Full Text: Prescott. Late mortality after acute hypoxic respiratory failure. Thorax 2017;epublished August 5th
- Abstract: Pollack. Idarucizumab for Dabigatran Reversal — Full Cohort Analysis. N Engl J Med 2017;377:431-441
- Full Text: Tiruvoipati. Intensive care discharge delay is associated with increased hospital length of stay: A multicentre prospective observational study. PLoS One 2017;12(7):e0181827
- Full Text: Ferrando. Rationale and study design for an individualised perioperative open-lung ventilatory strategy with a high versus conventional inspiratory oxygen fraction (iPROVE-O2) and its effects on surgical site infection: study protocol for a randomised controlled trial. BMJ Open 2017;7:e016765
- Thelin. Monitoring the Neuroinflammatory Response Following Acute Brain Injury. Front Neurol 2017;8:351
- Zoerle. Rethinking Neuroprotection in Severe Traumatic Brain Injury: Toward Bedside Neuroprotection. Front Neurol 2017;8:354
- Hasan. Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury. Front Neurol 2017;8:28
- Palanca. Electroencephalography and delirium in the postoperative period. Br J Anaesth 2017;119(2):294-307
- Callan. Heart failure – what’s new and what’s changed? Clin Med 2017;17:341-346
- Chen. Brain–Heart Interaction. Cardiac Complications After Stroke. Circulation Research. 2017;121:451-468
- Wong. Extracorporeal membrane oxygenation for severe pediatric respiratory failure. J Emerg Crit Care Med 2017;1:11
- Romano. Extracorporeal respiratory support in adult patients. J Bras Pneumol 2017;43(1):60-70
- Kan. Using omics approaches to understand pulmonary diseases. Respir Res 2017;18(1):149
- Tharmaraj. Haemolysis in Haemodialysis. Nephrology 2017;epublished July 27th
- Cortinovis. Should We Still Believe in Randomized Controlled Trials in Nephrology? Nephron 2017;136:281-286
- Delanaye. Serum Creatinine: Not So Simple! Nephron 2017;136:302-308
- Krinsley. Continuous glucose monitoring in the ICU: clinical considerations and consensus. Critical Care 2017;21:197
- Ehrmann. Nebulized antibiotics in mechanically ventilated patients: a challenge for translational research from technology to clinical care. Annals of Intensive Care 2017;7:78
- Vijayan. Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy. Journal of Intensive Care 2017;5:51
- Reece. The UK’s multidisciplinary response to an Ebola epidemic. Clin Med 2017;17:332-337
- Boucher. White Paper: Developing Antimicrobial Drugs for Resistant Pathogens, Narrow-Spectrum Indications, and Unmet Needs. 228–236
- Public Health England. Seasonal influenza: guidance for adult critical care units. Public Health England 2017;epublished July 28thPublic Health England 2017;epublished July 28th
- Goto. Bystander interventions for out-of-hospital cardiac arrests: substantiated critical components of the chain of survival. J Emerg Crit Care Med 2017;1:12
- Malik. Blood transfusions in critically ill cancer patients remain an area of uncertainty. J Emerg Crit Care Med 2017;1:13
- Mion. History of anaesthesia: The ketamine story – past, present and future. Eur J Anaesthesiol 2017;34(9):571-575
- Kissoon. Understanding fluid administration approaches in children with co-morbidities and septic shock. Critical Care 2017;21:204
- Anonymous. Charlie Gard and the limits of medicine. Lancet 2017;epublished August 5th
- Bugedo. Driving pressure: a marker of severity, a safety limit, or a goal for mechanical ventilation? Crit Care 2017;21(1):199
- Ferreira. Types of outcomes in clinical research. J Bras Pneumol 2017;43(1):5
- Khizar. Making difficult decisions with older patients on medical wards. Clin Med 2017;17:353-356
- Gordon. The physician’s role in perioperative management of older patients undergoing surgery. Clin Med 2017;17:357-359Clin Med 2017;17:357-359
- Offord. The emergence of sarcopenia as an important entity in older people. Clin Med 2017;17:363-366
- Stain. Should doctors work 24 hour shifts? BMJ 2017;358:j3522
- Morgan. Diagnostic Stewardship—Leveraging the Laboratory to Improve Antimicrobial Use. JAMA 2017;epublished July 31st
- Tillmann. Care at a non-university hospital: an independent risk factor for mortality in ARDS? Critical Care 2017;21:195
- Myers. The Paradox of Mindfulness: Seamus Heaney’s “St Kevin and the Blackbird”. JAMA 2017;318(5):427-428
- Arabi. A critical view on primary and secondary outcome measures in nutrition trials. Intensive Care Med 2017;epublished July 29th
- Reinhart. Recognizing Sepsis as a Global Health Priority — A WHO Resolution. N Engl J Med 2017;377:414-417
- van Niekerk. Hyperglycaemia in critically ill patients: the immune system’s sweet tooth. Critical Care 2017;21:202
- Zhou. Response to: Understanding the null hypothesis (H0) in non-inferiority trials. Critical Care 2017;21:201
- Kreeftenberg. Efficient organisation of intensive care units with a focus on quality: the non-physician provider. Critical Care 2017;21:118
- Eastwood. Targeted therapeutic mild hypercapnia after cardiac arrest. Critical Care 2017;21:196
- Russotto. No-touch methods of terminal cleaning in the intensive care unit: results from the first large randomized trial with patient-centred outcomes. Critical Care 2017;21:117
- Kiefer. Confounding variables impacting the association between duration of veno-arterial extracorporeal life support and mortality. Critical Care 2017;21:203
- Various. Acute Kidney Injury in Patients with Cancer. N Engl J Med 2017;377:499-501
It's now just 6 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Split between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3, the first large clinical trial examining angiotensin II in septic shock. We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year. There are still additional speakers to add to the programme, so the meeting will continue to grow and get better and better.
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
#BMBTL17 is a conference on resuscitation that focuses on the skills and knowledge needed to bring your critically ill patients…back to life !
With cutting edge topics and a world class faculty, the conferences will be packed with clinical pearls and only the stuff that matters !
Ventilation, airway, EKGs, pediatric pearls, ultrasound and so much more…don’t miss this amazing conference ! It will be held on October 16th 2017 in downtown Montreal.
FemInEM.org is excited to bring you our first ever, in person conference, FIX2017! The FemInEM Idea Exchange is all about education, inspiration and motivation. Our world renowned faculty will speak from their hearts and minds, providing the substance and spark for you to change the world. We will meet, greet and motivate each other, pushing the limits of our previous selves. You won't want to miss it - October 4th to 6th, NYC.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board