Welcome to the 261st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a short edition this week, partly due to time restrictions from attending the Intensive Care Society's State-of-the-Art Meeting, which was superb (congrats Ganesh et al). The highlight of this week's newsletter is a set of airway guidelines from the All India Difficult Airway Association. If you only have time to read one paper this week, try either this one on perioperative management of the bleeding patient or this paper on immunoglobulin therapy.
This week's Topic of the Week is biomarkers in critical care, starting with a general paper on biomarkers in critical illness: have we made progress? in tomorrow's Paper of the Day.
It's been quiet at Critical Care Horizons for the past year. If you have an idea you'd like to share or are interested in publishing a review article, please get in touch. CCH is a not-for-profit platinium open access journal here to serve the needs of the critical care community. Please note we don't publish research or case reports - we want new thinking, commentaries and perspectives.
- Abstract: Stone. Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease (EXCEL Trial). N Engl J Med 2016;375:2223-2235
- Abstract: Agar. Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative CareA Randomized Clinical Trial. JAMA Intern Med 2016;epublished December 5th
- Abstract: Shabaan. Conventional Versus Prolonged Infusion of Meropenem in Neonates with Gram Negative Late Onset Sepsis: A Randomized Controlled Trial. Pediatric Infectious Disease Journal 2016;epublished November 30th
- Abstract: Sjövall. Empirical mono- versus combination antibiotic therapy in adult intensive care patients with severe sepsis – A systematic review with meta-analysis and trial sequential analysis. J Infection 2016;epublished December 2nd
- Full Text: Panagioti. Controlled Interventions to Reduce Burnout in Physicians. A Systematic Review and Meta-analysis. JAMA Intern Med 2016;epublished December 5th
- Full Text: Soares. Delayed Nephrology Consultation and High Mortality on Acute Kidney Injury: A Meta-Analysis. Blood Purif 2017;43:57-67
- Abstract: Ray. Vancomycin and the Risk of AKI: A Systematic Review and Meta-Analysis. CJASN December 2016;11:(12):2132-2140
- Full Text: Afonso. Prevention of hospital-acquired bloodstream infections through chlorhexidine gluconate-impregnated washcloth bathing in intensive care units: a systematic review and meta-analysis of randomised crossover trials. Euro Surveill 2016;21(46)
- Abstract: Brummel. Frailty and Subsequent Disability and Mortality Among Patients With Critical Illness. Am J respir Crit Care Med 2016;epublished December 6th
- Full Text: Arulkumaran. Association between day and time of admission to critical care and acute hospital outcome for unplanned admissions to adult general critical care units: cohort study exploring the ‘weekend effect’. Br J Anaesth 2016;epublished December 7th
- Full Text: Schläpfer. A First Evaluation of OMNI®, A New Device for Continuous Renal Replacement Therapy. Blood Purif 2017;43:11-17
- Ziganshina. Cerebrolysin for acute ischaemic stroke. Cochrane Database of Systematic Reviews 2016, Issue 12. Art. No.: CD007026
- Rao. One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. Cochrane Database of Systematic Reviews 2016, Issue 12. Art. No.: CD005091
- McNamee. pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure. JICS 2016;epublished December 7th
- English. Aneurysmal SubArachnoid Hemorrhage—Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol. BMJ Open 2016;6:e012623
- Brown. Perioperative cognitive protection. Br J Anaesth 2016;117(suppl 3):iii52-iii61
- Samary. Immunomodulation after ischemic stroke: potential mechanisms and implications for therapy. Critical Care 2016;20:391
- Jadhav. Endovascular therapy for acute ischemic stroke: The standard of care. Brain Circ 2016;2:178-82
- Mehdi. Perioperative management of adult patients with a history of stroke or transient ischaemic attack undergoing elective non-cardiac surgery. Clin Med 2016;16:535-540
- Rozencwajg. Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with extracorporeal membrane oxygenation. Critical Care 2016;20:392
- Chan. Coexisting cytomegalovirus infection in immunocompetent patients with Clostridium difficile colitis. Journal of Microbiology, Immunology & Infection 2016;49(6):829-836
- Endre. The Role of Nephrologist in the Intensive Care Unit. Blood Purif 2016;43(1-3):78-81
- Koratala. Extracorporeal Ultrafiltration for Acute Heart Failure: Lost Battle or Lasting Opportunity. Blood Purif 2017;43:1-10
- Rizo-Topete. Critical Care Nephrology: A Multidisciplinary Approach. Blood Purif 2017;43:53-56
- Rizo-Topete. Acute Kidney Injury Risk Assessment and the Nephrology Rapid Response Team. Blood Purif 2017;43:82-88
- Ghadimi. Perioperative management of the bleeding patient. Br J Anaesth 2016;117(suppl 3):iii18-iii30
- Nunnally. Sepsis for the anaesthetist. Br J Anaesth 2016;117(suppl 3):iii44-iii51
- Johnston. Immunoglobulin therapy. Clin Med December 2016;16:576-579
- Simmons. Acute traumatic coagulopathy: pathophysiology and resuscitation. Br J Anaesth 2016;117(suppl 3):iii31-iii43
- Soffin. Enhanced recovery after surgery for primary hip and knee arthroplasty: a review of the evidence. Br J Anaesth 2016;117(suppl 3):iii62-iii72
- Fudulu. Current outcomes of off-pump versus on-pump coronary artery bypass grafting: evidence from randomized controlled trials. J Thorac Dis 2016;8(Suppl 10):S758-S771
- Davierwala. Current outcomes of off-pump coronary artery bypass grafting: evidence from real world practice. J Thorac Dis 2016;8(Suppl 10):S772-S786
- Athanasopoulos. Off-pump coronary artery bypass grafting in left main stem stenosis: outcomes, concerns and controversies. J Thorac Dis 2016;8(Suppl 10):S787-S794
- Guida. Off-pump coronary artery bypass grafting in high-risk patients: a review. J Thorac Dis 2016;8(Suppl 10):S795-S798
- Raja. Off-pump coronary artery bypass grafting in octogenarians. J Thorac Dis 2016;8(Suppl 10):S799-S807
- Chivasso. Impact of off-pump coronary artery bypass grafting on survival: current best available evidence. J Thorac Dis 2016;8(Suppl 10):S808-S817
- Sergeant. We should ban the OPCAB approach in CABG, just as we should ban jetliners and bicycles, or maybe not! J Thorac Dis 2016;8(Suppl 10):S818-S823
- Raja. Two decades of off-pump coronary artery bypass surgery: Harefield experience. J Thorac Dis 2016;8(Suppl 10):S824-S828
- Yanagawa. The future of off-pump coronary artery bypass grafting: a North American perspective. J Thorac Dis 2016;8(Suppl 10):S832-S838
- Myatra. All India Difficult Airway Association 2016 guidelines for the management of unanticipated difficult tracheal intubation in adults. Indian J Anaesth 2016;60:885-98
- Ramkumar. All India Difficult Airway Association 2016 guidelines for the management of unanticipated difficult tracheal intubation in obstetrics. Indian J Anaesth 2016;60:899-905
- Pawar. All India Difficult Airway Association 2016 guidelines for the management of unanticipated difficult tracheal intubation in Paediatrics. Indian J Anaesth 2016;60:906-14
- Kundra. All India Difficult Airway Association 2016 guidelines for the management of anticipated difficult extubation. Indian J Anaesth 2016;60:915-21
- Myatra. The All India Difficult Airway Association 2016 guidelines for tracheal intubation in the Intensive Care Unit. Indian J Anaesth 2016;60:922-30
- Brass. Platelets and hemostasis: a new perspective on an old subject. Blood Advances 2016;1:5-9
- Kapur. Counter Point: Platelets as immune-sensing cells. Blood Adv 2016;1:10-14
- Gunst. Acute severe illness in diabetes patients: is tolerating hyperglycemia beneficial? J Thorac Dis 2016;8(11):3012-3015
- Serebruany. Ticagrelor and heart surgery controversy: we may have better antiplatelet options. J Thorac Dis 2016;8(11):3016-3019
- Reade. Low dose dexmedetomidine for the prophylaxis of perioperative ICU delirium—how much evidence is enough? J Thorac Dis 2016;8(11):3020-3023
- Sellers. Dexmedetomidine: magic bullet or firing blanks? J Thorac Dis 2016;8(11):3024-3027
- Wutzler. Routine total-body CT for trauma room patients—life saver or needless radiation exposure? J Thorac Dis 2016;8(11):3040-3041
- Morelli. Esmolol in septic shock: old pathophysiological concepts, an old drug, perhaps a new hemodynamic strategy in the right patient. J Thorac Dis 2016;8(11):3059-3062
- Benito-González. Mean platelet volume: ready for prime time? J Thorac Dis 2016;8(11):E1481-E1483
- Huang. Would decompressive craniectomy really bring the hope to severe traumatic brain injury? J Thorac Dis 2016;8(11):E1505-E1507
- Kwon. Nephroprotective strategies in septic shock: the VANISH trial. J Thorac Dis 2016;8(11):E1508-E1510
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
The first release of tickets for Das SMACC sold out in just 2.5 hours this week. The next opportunity will be on Wednesday December 7th (depending on where you are in the world). If you haven't yet checked out the programme and workshops, then have a look on the SMACC website. The Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong will cover all your critical care questions.
(Image from Chensiyuan via Wikipedia)
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week