After a year of waiting, it's finally here - SMACC DUB has arrived! The programme, both scientific and social, look incredible, and a spectacular opening ceremony awaits on Tuesday morning. If you are lucky enough to be attending, go to as much as you can and be sure to get the most from the best critical care week of the year. Look out for for the big announcement of the location of SMACC 2017 - it may be coming to a city near to you. If you are in Dublin, say hi - I'll be around all week.
This newsletter is small, as my time has been consumed with preparation for SMACC and the Irish Critical Care - Clinical Trials Group workshop. It's with great delight that we publish the latest paper from Critical Care Horizons on Icatibant and its Therapeutic Indications. by Christian Longley. It's been a tough six months as we battled with an IT issue, but we're back and looking forward to publishing more great papers.
The other highlights of this newsletter are randomised controlled trials on inhaled prophylactic heparin for the prevention and management of pneumonia in ventilated ICU patients and the early use of albumin in children with extensive burns, plus a debate of the use of albumin as a resuscitative fluid in sepsis. If you only have time for one paper this week, after you've read the Icatibant paper, try this short commentary on a theme close to my heart - ARDS: Time to “separate the wheat from the chaff”.
This week's Topic of the Week is the future of critical care knowledge dissemination and publishing, which will be discussed in a plenary panel session on Tuesday afternoon, starting with a paper on open access publishing in tomorrow's Paper of the Day.
- Abstract: Bandeshe. Is inhaled prophylactic heparin useful for prevention and Management of Pneumonia in ventilated ICU patients? (IPHIVAP Trial). J Crit Care 2016;34:95–102
- Abstract: Simon. High-Flow Nasal Cannula Oxygen Versus Bag-Valve-Mask for Preoxygenation Before Intubation in Subjects With Hypoxemic Respiratory Failure. Respir Care 2016;epublished June 7th
- Abstract: Qureshi. Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage (ATACH-2). N Eng J Med 2016;epublished June 8th
- Full Text: Froessler. The Important Role for Intravenous Iron in Perioperative Patient Blood Management in Major Abdominal Surgery: A Randomized Controlled Trial. Annals of Surgery 2016;264(1):41–46
- Abstract: Müller. Evaluation of the “Early” Use of Albumin in Children with Extensive Burns: A Randomized Controlled Trial. Pediatric Critical Care Medicine 2016;17(6):e280–e286
- Abstract: Roolvink. Early Intravenous Beta-Blockers in Patients With ST-Segment Elevation Myocardial Infarction Before Primary Percutaneous Coronary Intervention. J Am Coll Cardiol 2016;67(23):2705-2715
- Abstract: Egal. Targeting oliguria reversal in perioperative restrictive fluid management does not influence the occurrence of renal dysfunction: A systematic review and meta-analysis. European Journal of Anaesthesiology 2016;33(6):425–435
- Abstract: Zhu. Nasogastric Nutrition versus Nasojejunal Nutrition in Patients with Severe Acute Pancreatitis: A Meta-Analysis of Randomized Controlled Trials. Gastroenterology Research and Practice 2016;6430632
- Abstract: Truche. Continuous renal replacement therapy versus intermittent hemodialysis in intensive care patients: impact on mortality and renal recovery. Intensive Care Med 2016;epublished June 3rd
- Full Text: Bagshaw. A prospective multicenter cohort study of frailty in younger critically ill patients. Critical Care 2016;20:175
- Full Text: Cotta. We need to optimize piperacillin-tazobactam dosing in critically ill patients—but how? Critical Care 2016;20:163
- Abstract: Giuliano. Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs. Pediatric Critical Care Medicine 2016;17(6):522–530
- Abstract: Sun. Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood. JAMA 2016;315(21):2312-2320
- Full Text: Singh. Right heart in septic shock: prospective observational study. Journal of Intensive Care 2016;4:38
- Abstract: Trásy. Early procalcitonin kinetics and appropriateness of empirical antimicrobial therapy in critically ill patients. A prospective observational study. J Crit Care 2016;34:50-55
- Abstract: Pana. Time to loss of brain function and activity during circulatory arrest. J Crit Care 2016;34:77-83
- Abstract: Klompas. Associations Between Different Sedatives and Ventilator-Associated Events, Length of Stay, and Mortality in Patients Who Were Mechanically Ventilated. Chest 2016;149(6):1373-1379
- Abstract: Nucci. Discontinuation of empirical antifungal therapy in ICU patients using 1,3-β-d-glucan. J Antimicrob Chemother 2016;epublished June 10th
- Fletcher. Modelling of Brain Deformation After Decompressive Craniectomy. Annals of Biomedical Engineering 2016;epublished June 8th
- Mitchell. An Overview of Sugammadex. ATOTW 332; epublished June 7th
- Convertino. The Compensatory Reserve For Early and Accurate Prediction Of Hemodynamic Compromise: A Review of the Underlying Physiology. Shock 2016;45(6):580–590
- Miller. Predicting and measuring fluid responsiveness with echocardiography. Echo Res Pract 2016;epublished May 24th
- Pozzi. Veno-arterial extracorporeal membrane oxygenation for cardiogenic shock due to myocarditis in adult patients. J Thorac Dis 2016
- Zein. Ventilator Weaning and Spontaneous Breathing Trials; an Educational Review. Emerg (Tehran). 2016 Spring;4(2):65–71
- Maciel. Back to Basics: Is There a Good Reason to Not Systematically Measure Urine Creatinine in Acute Kidney Injury Monitoring? Nephron 2016;epublished June 7th
- Vallon. Tubular Transport in Acute Kidney Injury: Relevance for Diagnosis, Prognosis and Intervention. Nephron 2016;epublished May 31st
- Torria. Heparin centenary – an ever-young life-saving drug. International Journal of Cardiology 2016;212(1):S1-S4
- Harenberg. Past, present, and future perspectives of heparins in clinical settings and the role of impaired renal function. International Journal of Cardiology 2016;212(1):S10-S13
- Cassinelli. Old and new applications of non-anticoagulant heparin. International Journal of Cardiology 2016;212(1):S14-S21
- Should Intravenous Albumin Be Used for Volume Resuscitation in Severe Sepsis/Septic Shock? Chest. 2016;149(6):1365-1372
- Law. Deficiencies in locating the cricothyroid membrane by palpation: We can’t and the surgeons can’t, so what now for the emergency surgical airway? Can J Anaesth 2016;63(7):791-796
- Humphries. Emerging Resistance, New Antimicrobial Agents … but No Tests! The Challenge of Antimicrobial Susceptibility Testing in the Current US Regulatory Landscape
Clin Infect Dis 2016;63(1):83-88
- Cariou. Focus on cardiac arrest. Intensive Care Med 2016;epublished June 1st
- Peters. Focus on paediatrics. Intensive Care Med 2016;epublished June 2nd
- Ho. Making good death more accessible: end-of-life care in the intensive care unit. Intensive Care Med 2016;epublished June 3rd
- Attar. The Hell of Syria’s Field Hospitals. N Engl J Med 2016;374:2205-2207
- Wight. Perioperative bridging anticoagulation for atrial fibrillation—the first randomised controlled trial. Perioperative Medicine 2016;5:14
- Berger. Hypotension and hypovolemia during hemodialysis: is the usual suspect innocent? Critical Care 2016;20:140
- Macfadyen. Ethics in practice: is it futile to talk about ‘futility’? European Journal of Anaesthesiology 2016;33(7):473–474
- Cardinal-Fernández. ARDS: Time to “separate the wheat from the chaff”. J Crit Care 2016;34:31–32
- Rady. Neuroscience and awareness in the dying human brain: Implications for organ donation. J Crit Care 2016;34:121-123
- De Waele. New generation indirect calorimeters for measuring energy expenditure in the critically ill: a rampant or reticent revolution? Critical Care 2016;20:138
- Vitorio. Improving the “urinary side” of acute kidney injury monitoring. Critical Care 2016;20:154
- Hammond. Considerations on Midodrine Use in Resolving Septic Shock. Chest 2016;149(6):1582-1583
- Raimondi. Clinical Data Are Essential to Validate Lung Ultrasound. Chest 2016;149(6):1575
- Pollet. Heart Block in a Pacemaker: Does This Mean Trouble?. Texas Heart Institute Journal 2016;43(3):270-271
- Ahsan. A 21-Year-Old Man With “Sloshing” in the Chest. Chest 2016;149(6):e169-e171
- Al-Hamrashdi. Right- and Left-Sided Embolic Phenomena in a Patient With Febrile Neutropenia. Chest 2016;149(6):e173-e175
- Foster. A 65-Year-Old Groundskeeper With High Fever, Pulmonary Nodules, and Thoracic Lymphadenopathy. Chest 2016;149(6):e191-e194
- Ataya. A 61-Year-Old Man With Shortness of Breath, Ascites, and Lower Extremity Edema. Chest 2016;149(6):e195-e199
- Koshkelashvili. Hyperkalemia after Missed Hemodialysis. N Engl J Med 2016;374:2268
- Rademakers. Ventricular Septal Defect after Acute Myocardial Infarction. N Engl J Med 2016;374:e28
The 9th UK Critical Care Research Forum is being held on 23rd – 24th June 2016 at the Sage Gateshead, with over 20 research proposals as well as sessions on adaptive trial design, international collaborations in critical care trials and patient-centred research. There is also a Forum dinner at the Baltic Centre for Contemporary Art. Registration is now open.
(image from Wikimedia)
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week