Welcome to the 193rd Critical Care Reviews Newsletter, bring you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.
The highlights of this week's newsletter are the STITCH (Trauma) trial, investigating early surgery in traumatic brain haemorrhage, meta analyses on enteral glutamine supplementation in critically ill patients and statin therapy in critically-ill patients with severe sepsis, observational studies on fluid balance following initial resuscitation in septic shock and in subarachnoid hemorrhage, as well as a series of four review articles from the Lancet Diabetes & Endocrinology, on endocrine and metabolic considerations in critically ill patients. If you ony have time for one review paper this week, try this one on the effects of hyperoxia during critical illness, from Critical Care.
I'm delighted to announce the Critical Care Reviews Meeting will commence an annual John Hinds Trauma Lecture, in memory of our colleague Dr John Hinds who tragically died last month. The inaugural talk will be given by John's good friend Dr Brian Burns, Assistant Professor of Emergency Medicine, University of Sydney and Research Director, Sydney HEMS, Australia. The title of his lecture is "Trauma Care - Back to the Future". This will be preceded by a memorial talk. The near finalised version of the programme is available on the meeting webpage. With Dr John Holcomb from Texas also speaking, this will provide an excellent opportunity to meet some world class trauma experts. In addition, both Dr Paul Young's exciting trials, SPLIT and HEAT, will be presented at one of the most prestigious sessions in the critical care calendar, the ESICM Hot Topics Session in Berlin in October, again making #CCR16 as up-to-date a meeting as you could attend.
To mark this inaugural lecture, this week's Topic of the Week is Helicopter Emergency Medical Services, starting with a paper on aeromedical transfer of the critically ill patient in tomorrow's Paper of the Day.
- Full Text: Mendelow. Early Surgery versus Initial Conservative Treatment in Patients with Traumatic Intracerebral Hemorrhage (STITCH (Trauma)): The First Randomized Trial. Journal of Neurotrauma 2015;32(17):1312-1323
- Abstract: Czarnetzki. Erythromycin for Gastric Emptying in Patients Undergoing General Anesthesia for Emergency Surgery: A Randomized Clinical Trial. JAMA Surg 2015;150(8):730
- Full Text: van Zanten. Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis. Critical Care 2015;19:294
- Abstract: Bashar.Corticosteroids and Occurrence of and Mortality from Infections in Severe Alcoholic Hepatitis: A Meta-analysis of Randomized Trials. Liver Int 2015;epublished August 17th
- Full Text: Han. Cleaning Hospital Room Surfaces to Prevent Health Care–Associated Infections: A Technical Brief. Ann Intern Med 2015;epublished August 11th
- Full Text: Thomas. Statin therapy in critically-ill patients with severe sepsis: a review and meta-analysis of randomized clinical trials. Minerva Anestesiologica 2015;81(8):921-30
- Abstract: Santacruz. Modulation of Dietary Lipid Composition During Acute Respiratory Distress Syndrome: Systematic Review and Meta-Analysis. JPEN J Parenter Enteral Nutr 2015;39(7):837-846
- Abstract: Sandhu. Utilization of Mechanical Circulatory Support in Patients Undergoing Percutaneous Coronary Intervention: Insights From the NCDR. Circulation 2015;epublished August 18th
- Abstract: Sun. Postoperative Hypoxemia Is Common and Persistent: A Prospective Blinded Observational Study. Anesth & Analg 2015;121:(3):709-715
- Abstract: Bhatt. β-Blockers are associated with a reduction in COPD exacerbations. Thorax 2015;epublished August 17th
- Full Text: Peralta. Trauma resuscitation requiring massive transfusion: a descriptive analysis of the role of ratio and time. World Journal of Emergency Surgery 2015;10:36
- Abstract: Charron. Difficulties encountered by physicians in interpreting focused echocardiography using a pocket ultrasound machine in prehospital emergencies. Eur J Emerg Med 2015;22(1):17-22
- Abstract: Chen. Targeted Fluid Minimization Following initial Resuscitation in Septic Shock: A Pilot Study. Chest 2015;epublished August 20th
- Abstract: Kissoon. Positive Fluid Balance Is Associated With Poor Outcomes in Subarachnoid Hemorrhage. J Stroke Cerebrovasc Dis 2015;epublished August 12th
- Abstract: Cook. Personalizing Death in the Intensive Care Unit: The 3 Wishes Project: A Mixed-Methods Study. Ann Intern Med 2015;163(4):271-279
- Abstract: Walkey. Practice patterns and outcomes of treatments for atrial fibrillation during sepsis: A propensity-matched cohort study. Chest 2015;epublished August 13th
- Abstract: Hsu. The Association Between Indwelling Arterial Catheters and Mortality in Hemodynamically Stable Patients With Respiratory Failure: A Propensity Score Analysis. Chest 2015;epublished August 13th
- Full Text:van Paridon. Timing of antibiotics, volume, and vasoactive infusions in children with sepsis admitted to intensive care. Critical Care 2015;19:293Critical Care 2015;19:293
- Peng. Prophylactic abdominal drainage for pancreatic surgery. Cochrane Database of Systematic Reviews 2015, Issue 8. Art. No.: CD010583
- Webster. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database of Systematic Reviews 2015, Issue 8. Art. No.: CD007798
- Kuhn. Preoperative statin therapy for patients undergoing cardiac surgery. Cochrane Database of Systematic Reviews 2015, Issue 8. Art. No.: CD008493
- Blackwood. Core Outcomes in Ventilation Trials (COVenT): protocol for a core outcome set using a Delphi survey with a nested randomised trial and observational cohort study. Trials 2015;16(1):368
- Tong. Standardised outcomes in nephrology – Haemodialysis (SONG-HD): study protocol for establishing a core outcome set in haemodialysis. Trials 2015;16:364
- Wilken. Topical clobetasol for the treatment of toxic epidermal necrolysis: study protocol for a randomized controlled trial. Trials 2015;16:374
- Cheng. Intravenous Thrombolysis for Acute Ischemic Stroke Within 3 Hours Versus Between 3 and 4.5 Hours of Symptom Onset. Neurohospitalist 2015;5(3):101–109
- Fugate. Absolute and Relative Contraindications to IV rt-PA for Acute Ischemic Stroke. Neurohospitalist 2015;5(3):110–121
- O’Carroll. What is the Role for Intra-Arterial Therapy in Acute Stroke Intervention? Neurohospitalist 2015;5(3):122–132
- O’Carroll. Management of Postthrombolysis Hemorrhagic and Orolingual Angioedema Complications. Neurohospitalist 2015;5(3):133–141
- Demel. Basilar Occlusion Syndromes: An Update. Neurohospitalist 2015;5(3):142–150
- Mijalski. TIA Management: Should TIA Patients be Admitted? Should TIA Patients Get Combination Antiplatelet Therapy? Neurohospitalist 2015;5(3):151–160
- Rubin. What to do With Wake-Up Stroke. Neurohospitalist 2015;5(3):161–172
- Cumbler. In-Hospital Ischemic Stroke. Neurohospitalist 2015;5(3):173–181
- Rentrop. Reperfusion Therapy for Acute Myocardial Infarction: Concepts and Controversies from Inception to Acceptance. American Heart Journal 2015;epublished August 14th
- Lee. General Considerations of Ruptured Abdominal Aortic Aneurysm: Ruptured Abdominal Aortic Aneurysm. Korean Journal of Thoracic and Cardiovascular Surgery 2015;48(1):1-6
- Helmerhorst. the effects of hyperoxia during critical illness. Critical Care 2015;19:284
- Bouroche. Preoxygenation and general anesthesia: a review. Minerva Anestesiologica 2015;81(8):910-20
- Chen. Prognostic factors in the acute respiratory distress syndrome. Clin Transl Med. 2015;4:23
- Allen. Surgery of the Trachea. Korean Journal of Thoracic and Cardiovascular Surgery 2015;48(4):231-237
- van der Hulle. Recent developments in the diagnosis and treatment of pulmonary embolism. J Intern Med 2015;epublished August 19th
- Wang. Human autoimmune diseases: a comprehensive update. (Review). J Intern Med 2015;epublished July 25th
- Ferguson. Management of intestinal obstruction in advanced malignancy. Ann Med Surg (Lond) 2015;4(3):264–270
- Casaer. Nutritional support in critical illness and recovery: Lancet Diabetes Endocrinol 2015;3(9):734–745
- Cheungpasitporn. Lactate clearance and metabolic aspects of continuous high-volume hemofiltration. Clin Kidney J 2015;8 (4):374-377
- Mesotten. Glucose management in critically ill adults and children. Lancet Diabetes Endocrinol 2015;3(9):723–33
- Boonen. New insights into the controversy of adrenal function during critical illness. Lancet Diabetes Endocrinol 2015;epublished June 10th
- Fliers. Thyroid function in critically ill patients. Lancet Diabetes Endocrinol 2015;epublished June 10th
- Velissaris. The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate. Crit Care Res Pract 2015;2015:605830
- Minnet. Venous thromboembolism in the ICU: main characteristics, diagnosis and thromboprophylaxis. Critical Care 2015;19:287
- Kesecioglu. What is new in selective decontamination of the digestive tract? Intensive Care Med 2015;epublished August 18th
- Liapikou. Ceftobiprole for the treatment of pneumonia: a European perspective. Drug Design, Development and Therapy 2015;9:4565-4572
- Klar. Ethical concerns for anesthesiologists during an Ebola threat. Can J Anesth 2015;62:996–999
- Ñamendys-Silva. Tumor lysis syndrome in the emergency department: challenges and solutions. Open Access Emergency Medicine 2015;7:39-44
- Sartelli. WSES guidelines for management of Clostridium difficile infection in surgical patients. World Journal of Emergency Surgery 2015;10:38
- NICE. Antimicrobial stewardship: systems and processes for effective antimicrobial medicine use. NICE 2015;epublished August 18th
- Mehta. Unplanned extubation: securing the tool of our trade. Intensive care Med 2015;epublished August 12th
- Blann. Nonvitamin K antagonist oral anticoagulants (NOACs): the tide continues to come in. Vascular Health and risk Management 2015;11:489-492
- Douglas. Should CT Angiography be a Routine Component of Acute Stroke Imaging? Neurohospitalist 2015;5(3):97–98
- White. Caveat doctor. Anaesthesia 2015;70:1013–1016
- Agrawal. State of the globe: Toxin and toxic genes associated with Staphylococcus aureus and clinical implication. J Global Infect Dis 2015;7:95-6
- Kellermann. Obstacles to Developing Cost-Lowering Health Technology: The Inventor’s Dilemma. JAMA 2015;epublished August 17th
- Hargreaves. Five questions to consider before conducting a stepped wedge trial. Trials 2015;16:350
- Copas. Designing a stepped wedge trial: three main designs, carry-over effects and randomisation approaches. Trials 2015;16:352
- Liew. Awake tracheal intubation in a patient with a supraglottic mass with the Bonfils fibrescope after failed attempts with a flexible fibrescope. Singapore Med J 2015;56(8):e139-e141with a flexible fibrescope. Singapore Med J 2015;56(8):e139-e141
- Koch. Intravenous immunoglobulin in necrotizing fasciitis – A case report and review of recent literature. Ann Med Surg (Lond) 2015;4(3):260–263
- Özkurtul. Severe cardiac trauma or myocardial ischemia? Pitfalls of polytrauma treatment in patients with ST-elevation after blunt chest trauma. Med Surg (Lond) 2015;4(3):254-259
- Jehangir. Electrical Alternans with Pericardial Tamponade. N Engl J Med 2015;373:e10
- Jayakrishnan. Black pleural effusion. Lancet 2015;386(9995):e7
I'm delighted to announce the Critical Care Reviews Meeting 2016 will hold the inaugural John Hinds Trauma Lecture, given by John's good friend Dr Brian Burns, from Sydney HEMS. This hopefully annual lecture will further John's legacy of improving trauma care worldwide. As with all the talks at the meeting, this will also be recorded and made freely available online. This Lecture will also be preceded by a memorial talk on Dr John Hinds. The final programme should be released next week, but the meeting webpage contains a good overview of the day. Complementing the website and newsletter, the meeting theme is to discuss the biggest critical care studies of the year, with the chief investigators for these studies present.
Due to hugely successful previous events, the meeting has moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic, From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. Similarly, Prof Danny McAuley (Belfast, Northern Ireland) will also review a post-ICU rehab study, the REVIVE trial. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. The finalised programme won't be released until later this Autumn, but don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.
Under the inspired guidance of meeting organiser Ganesh Suntharalingam, this year's State-of-the-Art Meeting promises an exciting programme in a new dynamic format. It aims to be the first major national society to fully embrace social media and free open access medical education, with an opening plenary session and a workshop, as well full integration of Twitter questions into sessions, live blogging, and open-access AV materials.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week