Welcome to the 180th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.
The highlight of this week's newsletter are a randomized controlled trial on restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding, an ATS guideline on managing conscientious objections in intensive care medicine (published in January, but it's taken me a while to find an OA version), and review articles on neuromonitoring of patients with severe traumatic brain injury and recent advances in the diagnosis and treatment of acute myocardial infarction.
Due to hugely successful previous events, the Critical Care Reviews Meeting 2016 has moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic. As before, the meeting theme is to review the biggest studies of the previous year, with chief investigators present where possible to discuss their work in person. From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. Similarly, Prof Danny McAuley (Belfast, Northern Ireland) will also review a post-ICU rehab study, the REVIVE trial. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. The finalised programme won't be released until later this Autumn, but don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.
There are just weeks to one of the biggest, and definitely the best, critical care conference in the world. The next SMACC Conference is on June 23rd to 26th, in Chicago, USA. With its informal manner and flat hierarchy, this event delivers on its promise to provide top class critical care education in a fun, modern way. Speakers are deliberately chosen for their ability to present and convey information, rather than their academic or social media status, marking this as the field leader in medical conferencing. With an emphasis on TED-like presentation styles, minimal slides and maximal social media involvement, this is the future of medical meetings. In addition to numerous world-leading academics, many active in the altruistic social media world of FOAM are there to contribute, including helping deliver a massive set of workshops the day before the main meeting begins. In the main programme, I'll be giving a talk on kicking perioperative goals, and also debating Prof Paul Marik on the usefulness, or not, of predicting fluid responsiveness. I hope to see you there - I'll need all the support I'll can get!
The ICSI host a superb three day ESICM meeting at Dubin Castle on June 11th to 13th, focusing on every aspect of respiratory critical care. From mechanical ventilation to ARDS to heart-lung interactions, this event is ideal for anyone interested in updating their knowledge in this field, under the guidance of some of the leading names in the area. I'll be attending, so say hi if you're in Dublin.
This year's State-of-the-Art Meeting promises an exciting programme in a new dynamic format. With strong social media input, and fresh ideas from those successfully delivering free educational content through various FOAM websites and events, this conference will be very different to before. Covering every CPD requirement, and attracting the most eminent researchers from the UK and beyond, the State-of-the-Art meeting remains the biggest critical care conference in the UK. I'll be on the debate trail again, taking on two world experts in respiratory failure, Dr Eddy Fan and Prof Luciano Gattinoni.
- Abstract: Jairath. Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial. Lancet 2015;epublished May 5th
- Abstract: Wagenlehner. Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI). Lancet 2015;385(9981):1949–1956
- Full Text: Paul. Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trial. BMJ 2015;350:h2219
- Abstract: Lunardi. Comparison of lung expansion techniques on thoracoabdominal mechanics and incidence of pulmonary complications after upper abdominal surgery: a randomized and controlled trial. Chest 2015;epublished May 14th
- Abstract: Wilson. Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. Lancet 2015;385(9981):1966–1974
- Abstract: Vargas. Effects of in-hospital low targeted temperature after out of hospital cardiac arrest: A systematic review with meta-analysis of randomized clinical trials. Resuscitation 2015;91:8–18
- Full Text: Chen. Impact of daily bathing with chlorhexidine gluconate on ventilator associated pneumonia in intensive care units: a meta-analysis. J Thorac Dis 2015;7(4):746-53
- Abstract: Bajaj. Prognostic value of troponins in acute nonmassive pulmonary embolism: A meta-analysis. Heart and Lung 2015;epublished May 11th
- Abstract: Shankar-Hari. Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis. Intensive Care Med 2015;epublished May 14th
- Abstract: Beitland. Thromboprophylaxis with low molecular weight heparin versus unfractionated heparin in intensive care patients: a systematic review with meta-analysis and trial sequential analysis. Intensive Care Med 2015;epublished May 14th
- Abstract: Serafim. Pharmacologic prevention and treatment of delirium in intensive care patients: A systematic review. J Crit Care 2015;epublished April 17th
- Abstract: Bailly. Failure of Empirical Systemic Antifungal Therapy in Mechanically Ventilated Critically Ill Patients. Am J Respir Crit Care Med 2015;191(10):1139-1146
- Full Text: Kao. Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy. Critical Care 2015;19:228
- Abstract: Bourdeaux. Evaluation of an intervention to reduce tidal volumes in ventilated ICU patients. Br J Anaesth 2015;epublished May 15th
- Abstract:: Maissan. Ultrasonographic measured optic nerve sheath diameter as an accurate and quick monitor for changes in intracranial pressure. JNS 2015;epublished May 8th
- Abstract: Pu. Weaning critically ill patients from mechanical ventilation: A prospective cohort study. J Crit Care. 2015;epublished April 16th
- Abstract: Nazerian. Accuracy of lung ultrasound for the diagnosis of consolidations when compared to chest computed tomography. Am J Emerg Med 2015;33(5):620–625
- Abstract: Lee. Intraosseous Versus Central Venous Catheter Utilization and Performance During Inpatient Medical Emergencies. Crit Care Med 2015;43(6):1233-1238
- Abstract: Wintermann. Stress Disorders Following Prolonged Critical Illness in Survivors of Severe Sepsis. Crit Care Med 2015;43(6):1213–1222
- Abstract: Sjoding. Hospitals With the Highest Intensive Care Utilization Provide Lower Quality Pneumonia Care to the Elderly. Crit Care Med 2015;43(6):1178–1186
- Aries. Neuromonitoring of patients with severe traumatic brain injury at the bedside. Neth J Crit Care 2015;20(2):6-12
- Valentino. Endogenous opioids: opposing stress with a cost. F1000Prime Reports 2015;7:(58)
- Roca-Oporto. Pneumococcal disease in adult solid organ transplantation recipients. World J Clin Infect Dis 2015;5(1):1-10
- Jo. Role of novel oral anticoagulants in the management and prevention of venous thromboembolism. World J Hematol 2015;4(1):1-9
- Gopinathannair. Management of tachycardia. F1000Prime Reports 2015;7:(60)
- Reinstadler. Copeptin Testing in Acute Myocardial Infarction: Ready for Routine Use? Dis Markers 2015;2015:614145
- Singh. Advances in the understanding and management of heart transplantation. F1000Prime Reports 2015;7:(52)
- Gordan. Autonomic and endocrine control of cardiovascular function. World J Cardiol 7(4):204-214
- Andrikopoulos. Flecainide: Current status and perspectives in arrhythmia management. World J Cardiol 2015;7(2):76-85
- Reddy. Recent advances in the diagnosis and treatment of acute myocardial infarction. World J Cardiol 2015;7(5):243-276
- Wong. Backs against the Wall: Novel and Existing Strategies Used during the 2014-2015 Ebola Virus Outbreak. Clin Microbiol Rev 2015;28(3):593-601
- Engels. Biomarkers of Lung Injury in Cardiothoracic Surgery. Dis Markers 2015;2015:472360
- Raevens. Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment. Liver Int 2015;35:1646–1660
- Acevedo. Multiresistant bacterial infections in liver cirrhosis: Clinical impact and new empirical antibiotic treatment policies. World J Hepatol 2015;7(7):916-921
- Yadav. Care of the patient with cirrhosis. Clinical Liver Disease 2015;5:100–104
- Martin. Update on MELD and organ allocation. Clinical Liver Disease 2015;5:105–107
- Pouliquen. Recent advances in renal transplantation: antibody-mediated rejection takes center stage. F1000Prime Reports 2015;7:(51)
- Chen. Transplant renal artery stenosis: clinical manifestations, diagnosis and therapy. Clin Kidney J 2015;8(1):71–78
- Karagiannis. Adrenal insufficiency in patients with decompensated cirrhosis. World J Hepatol 2015;7(8):1112-1124
- Rastegar. Rational fluid therapy for sepsis and septic shock; what do recent studies tell us? Arch Iran Med 2015;18(5):308-13
- Wong. Backs against the Wall: Novel and Existing Strategies Used during the 2014-2015 Ebola Virus Outbreak. Clin Microbiol Rev 2015;28(3):593-601
- Lombardo. Mesenchymal stem cells as a therapeutic tool to treat sepsis. World J Stem Cells 2015;7(2):368–379
- Lewis-Newby. An Official American Thoracic Society Policy Statement: Managing Conscientious Objections in Intensive Care Medicine. Am J Respir Crit Care Med 2015;191(2):219–227
- Tripathi. UK guidelines on the management of variceal haemorrhage in cirrhotic patients. Gut 2015;0:1–25
- Nightingale. Peri-operative management of the obese surgical patient 2015. Anaesthesia 2015;epublished May 7th
- Shamseer. CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration. BMJ 2015;350:h1793
- Polderman. An injured brain needs cooling down: yes. Intensive Care Med 2015;epublished May 14th
- Darmon. Balancing the “humors” in severe sepsis: still a role for extracorporeal therapies? Intensive Care Med 2015;epublished May 14th
- Mélot. To score or not to score during triage in the emergency department? Intensive Care Med 2015;epublished May 14th
- Bhatia. Fluid resuscitation in severe sepsis and septic shock: Shifting goalposts. Indian J Anaesth 2015;59:269-71
- Sandroni. Neuroprognostication after cardiac arrest in Europe: New timings and standards. Resuscitation 2015;90:A4–A5
- De Waele. The abdominal compartment syndrome: evolving concepts and future directions. Critical Care 2015;19:211
- Gokmen. Mount Fuji sign following surgical drainage of spinal epidural abscess. QJM 2015;epublished May 3rd
- Snel. Ischaemic optic neuropathy in a blunt abdominal trauma patient with profound shock: a case report and concise review of possible risk factors. Neth J Crit Care 2015;20(2):26-8
- van Vugt. Unexplained high lactate levels after long bone fractures: consider cerebral fat embolism syndrome. Neth J Crit Care April 2015;20(2):21-5
- Kreeftenberg. Cholesterol in the ICU: a cheap and reliable marker for illness severity? Neth J Crit Care 2015;20(2):17-20
- El-Kerish. Unusual Placement of a Central Venous Catheter: Left Pericardiophrenic Vein. West J Emerg Med. 2015;16(3):422–423
- Contou. Golden sputum. Intensive Care Med 2015;epublished May 14th
- Saptharishi. Ventilator-associated pneumonia or bacterial colonization of the airway, what do probiotics decrease? Intensive Care Med 2015;epublished May 14th
- Lazaridis. Routine recovery of organs for transplantation can be acceptable. Intensive Care Med 2015;epublished May 14th
- Hofmeijer. Outcome prediction in postanoxic coma with electroencephalography: The sooner the better. Resuscitation 2015;91:e1–e2
After almost a year of preparation, the first issue of the new genuine open access critical care journal, Critical Care Horizons is nearing publication. This is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have something interesting to say, and can say it in an engaging manner, please get in touch.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week