Welcome to the 278th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a small newsletter this week, whose highlight is unusually the news of the release of a service called Unpaywall, which is a legal method of accessing non-copyrighted pre-print versions of otherwise paywalled articles (h/t @codingbrown & @psirides). Similarly, there is a move towards making citations open-access, with the launch of Initiative for Open Citations (h/t @mr_astvad). See the news section for more information on both of these great endeavours.
While it seems as if #CCR17 has only just passed, we're working hard on putting together #CCR18. As ever, the aim is to have the chief investigators for the biggest trials of the year come to Titanic in Belfast and discuss their work. Next year's meeting is already shaping up to be another fantastic event. From Brisbane, we have Prof Bala Ventakesh, CI for the largest sepsis study ever performed, the ADRENAL trial, investigating steroids in septic shock. Alistair Nichol, who divides his time between Melbourne and Dublin, will discuss TRANSFUSE, the latest trial examining age of transfused red cells in the critically ill. Jean-Baptiste Lascarrou, from Nantes, will present his MACMAN trial, comparing direct laryngoscopy with video laryngoscopy in the ICU, which is sure to generate much discussion. Several other chief investigators will be added to the programme during the year as further trials either near completion or are published. If you're not sure what the meeting is about, check out either the talks from previous years or the promotional movie. If you want to stay up-to-date with advances in critical care in 2017, this is the meeting for you.
This week's Topic of the Week is the great series from the New England Journal of Medicine on the Changing Face of Clinical Trials, starting with a paper on integrating randomized comparative effectiveness research with patient care in tomorrow's Paper of the Day.
- Abstract: Patsaki. Effect of neuromuscular stimulation and individualized rehabilitation on muscle strength in Intensive Care Unit survivors: A randomized trial. J Crit Care 2017;40:76-82
- Full Text: Cambau. Performance and economic evaluation of the molecular detection of pathogens for patients with severe infections: the EVAMICA open-label, cluster-randomised, interventional crossover trial. Intensive Care Med 2017;epublished April 3rd
- Abstract: Brendish. Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial. Lancet Respir Med 2017;epublished April 6th
- Full Text: Wu. Impregnated central venous catheters in children: a systematic review of randomized controlled trials. Intensive Care Med 2017;epublished March 27th
- Abstract: Tasker. Updating Evidence for Using Hypothermia in Pediatric Severe Traumatic Brain Injury: Conventional and Bayesian Meta-Analytic Perspectives. Ped Crit Care Med 2017;18(4):355-362
- Abstract: Fink. International Survey of Critically Ill Children With Acute Neurologic Insults: The Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment Study. Ped Crit Care Med 2017;18(4):330–342
- Abstract: Vibede. The effect of fresh frozen plasma in critically ill patients. Acta Anaesthesiol Scand 2017;61(5):492-501
- Abstract: Crotti. Spontaneous Breathing during Extracorporeal Membrane Oxygenation in Acute Respiratory Failure. Anesthesiology 2017;126:678-687
- Abstract: Nelson. The Voice of Surrogate Decision Makers: Family Responses to Prognostic Information in Chronic Critical Illness. Am J Respir Crit Care Med 2017;epublished April 5th
- Davidson. Amylase in drain fluid for the diagnosis of pancreatic leak in post-pancreatic resection. Cochrane Database of Systematic Reviews 2017, Issue 4. Art. No.: CD012009
- Sandercock. Low-molecular-weight heparins or heparinoids versus standard unfractionated heparin for acute ischaemic stroke. Cochrane Database of Systematic Reviews 2017, Issue 4. Art. No.: CD000119
- Chamsi-Pasha. Do not resuscitate, brain death, and organ transplantation: Islamic perspective. Avicenna J Med 2017;7:35-45
- Chartrain. Novel and emerging technologies for endovascular thrombectomy. Neurosurgical Focus 2017;42(4):E12
- Yoon. Stent technology in ischemic stroke. Neurosurgical Focus 2017;42(4):E11
- Kilburg. Advanced imaging in acute ischemic stroke. Neurosurgical Focus 2017;42(4):E10
- Shishehbor. Cardiogenic shock: From ECMO to Impella and beyond. Cleveland Clinic Journal of Medicine 2017;84(4):287-295
- Kimura. Point-of-care cardiac ultrasound techniques in the physical examination: better at the bedside. Heart 2017;epublished March 4thHeart 2017;epublished March 4th
- Cheung. Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management. World J Gastroenterol 2017;23(11):1954–1963
- Arabi. The intensive care medicine research agenda in nutrition and metabolism. Intensive Care Med 2017;epublished April 3rd
- Bellomo. Acute kidney injury in sepsis. Intensive Care Med 2017;epublished March 31st
- Schneider. The AKI glossary. Intensive Care Med 2017;epublished April 1st
- Ciccia. Pediatric acute kidney injury: prevalence, impact and management challenges. International Journal of Nephrology and Renovascular Disease 2017;10:77—84
- Awdishu. The 6R’s of drug induced nephrotoxicity. BMC Nephrology 2017;18:124
- Halfdanarson. Emergencies in Hematology and Oncology. Mayo Clin Proc 2017;92(4):609-641
- Gavva. Four-factor prothrombin complex concentrates: effectiveness in the reversal of anticoagulation. International Journal of Clinical Transfusion Medicine 2017;5:39—47
- Park. Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis. Infect Chemother 2017;49(1):10-21
- Permentier. Carbon dioxide poisoning: a literature review of an often forgotten cause of intoxication in the emergency department. International Journal of Emergency Medicine 2017;10:14
- Faley. Best Practices for Medication Utilization Evaluations in Postsurgical Pain Management. Curr Emerg Hosp Med Rep 2017;5:33
- Sessler. Nitrous Oxide is an Effective and Safe Anesthetic. Turk J Anaesthesiol Reanim 2017;45(1):1–2
- Rossaint. Should we Still use Nitrous Oxide in our Clinical Practice? No! Turk J Anaesthesiol Reanim. 2017;45(1):3–5
- Munshi. Inhaled nitric oxide and acute kidney injury: new insights from observational data. Critical Care 2017;21:83
- Klompas. Beware the siren’s song of novel endotracheal tube designs. Intensive Care Med 2017;epublished March 31st
- Martin-Loeches. Focus on infection and sepsis 2017. Intensive Care Med 2017;epublished April 4th
- Mangione. When the tail wags the dog: Clinical skills in the age of technology. Cleveland Clinic Journal of Medicine 2017;84(4):278-280
- Bein. Understanding ethical decisions for patients on extracorporeal life support. Intensive Care Med 2017;epublished March 27th
- Sharfstein. Vaccines and the Trump Administration. JAMA 2017;317(13):1305-1306
- Smith. Critical illness: the brain is always in the line of fire. Intensive Care Med 2017;April 6th
- Brookera. Chemical dependence in anesthesiologists: the actuality. Brazilian Journal of Anesthesiology 2017;epublished April 5th
- Cutuli. Lice, rodents, and many hopes: a rare disease in a young refugee. Critical Care 2017;21:81
- Bloomstone. Goal-Directed Fluid Therapy: What the Mind Does Not Know, the Eye Cannot See. Turk J Anaesthesiol Reanim 2017;45(1):56–58
- Errando. Some Considerations Regarding the Pro and Con articles between Drs. Hedenstierna and Pelosi on Intraoperative Ventilation and Pulmonary Outcomes. Turk J Anaesthesiol Reanim 2017;45(1):59–60
- Various. Clinical Trials Series — Large Pharma. N Engl J Med 2017;376:e28
There are just 5 months left unit Das SMACC and all tickets have now been sold for the main conference. If you are interested in attending the workshops, there are a very small number of tickets left for the Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong. With a superb international faculty, this half-day event will address your burning critical care questions.
(Image from Chensiyuan via Wikipedia)
The Critical Care Symposium (CCS) was initiated to satisfy the purpose of creating a world-class environment for medical enrichment in the North of England, particularly in Manchester. It was envisioned as a common informal platform wherein professionals from the field of critical care could provide and enhance the knowledge of delegates on current practices and related fields of interest.
Now in its 14th year, the annual conference regularly has renowned speakers from around the world and attracts more than 400 delegates. And this year is no different. In recent years a parallel course on ultrasound has been conducted alongside the conference that provides ample hand-on experience over two days. This year will host the 7th Ultrasound in Acute Care. For more information please visit http://critcaresymposium.co.uk.
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week