Welcome to the 308th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a massive issue this week, packed with great randomised controlled trials, investigating infected necrotising pancreatitis, PCI in stable angina, as well as the CULPRIT-SHOCK Trial, comparing culprit vessel with multi-vessel PCI in acute MI-related cardiogenic shock, and the presently unpublished SMART trial, comparing saline with balanced crystalloids in a single centre, cluster-randomized multiple crossover trial including 15,802 critically ill adults. There is also the second part of the critical illness-related corticosteroid insufficiency guideline from both ESICM & SCCM; and numerous fantastic reviews, on topics such as cardiovascular oncologic emergencies, adverse effects of crystalloid and colloid fluids and environmental bacterial contamination in the ICU. If you only have time to read one review article this week, try this paper from Adrian Wong and Olusegun Olusanya on a current and important issue - burnout and resilience
This week's Topic of the Week is neurocritical care, based on a set of articles from Neurocritical Care, starting with a paper on invasive multimodality neuromonitoring in tomorrow's Paper of the Day.
- Full Text: Thiele. PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock (CULPRIT-SHOCK). N Engl J Med 2017;epublished October 30th
- Abstract: van Brunschot. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet 2017;epublished November 3rd
- Abstract: Cook. Red blood cell storage and in-hospital mortality: a secondary analysis of the INFORM randomised controlled trial. Lancet Haematology 2017;4(11):e544–e552
- Abstract: Al-Lamee. Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial.Lancet 2017;epublished November 2nd
- Unpublished: SMART trial via Medscape
- Full Text: Palli. The impact of N-acetylcysteine and ascorbic acid in contrast-induced nephropathy in critical care patients: an open-label randomized controlled study. Critical Care 2017;21:269
- Full Text: Ydemann. Intraoperative clonidine for prevention of postoperative agitation in children anaesthetised with sevoflurane (PREVENT AGITATION): a randomised, placebo-controlled, double-blind trial (PREVENT AGITATION). Lancet Child Adolesc Health 2017;epublished November 1st
- Abstract: Varenne. Drug-eluting stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial. Lancet 2017;epublished November 1st
- Full Text: Kahn. Impact of total occlusion of culprit artery in acute non-ST elevation myocardial infarction: a systematic review and meta-analysis. European Heart Journal 2017;38(41):3082–3089European Heart Journal 2017;38(41):3082–3089
- Abstract: Messina. Use of the Fluid Challenge in Critically Ill Adult Patients: A Systematic Review. Anesth Analg 2017;125(5):1532–1543
- Abstract: Wu. Administration of Hypertonic Solutions for Hemorrhagic Shock: A Systematic Review and Meta-analysis of Clinical Trials. Anesth Analg 2017;125(5):1549-1557
- Abstract: Schieren. Continuous lateral rotational therapy in trauma-A systematic review and meta-analysis. J Trauma Acute Care Surg 2017;83(5):926-933
- Full Text: Saadeh. The impact of blood pressure management after spinal cord injury: a systematic review of the literature. Neurosurgical Focus 2017;43(5):E20
- Full Text: Mohammed. The 21st-century challenge to neurocritical care: the rise of the superbug Acinetobacter baumannii. A meta-analysis of the role of intrathecal or intraventricular antimicrobial therapy in reduction of mortality. Neurosurgical Focus 2017;43(5):E8
- Full Text: Barjaktarevic. Noninvasive ventilation in difficult endotracheal intubation: systematic and review analysis. Anaesthesiol Intensive Ther 2017;49(4):294-302
- Abstract: Needham. Core Outcome Measures for Clinical Research in Acute Respiratory Failure Survivors. An International Modified Delphi Consensus Study. Am J Respir Crit Care Med 2017;196(9):1122–1130
- Full Text: Vallés. Incidence of airway complications in patients using endotracheal tubes with continuous aspiration of subglottic secretions. Annals of Intensive Care 2017;7:109
- Full Text: Jamjoom. Prospective, multicentre study of external ventricular drainage-related infections in the UK and Ireland. J Neurol Neurosurg Psychiatry 2017;epublished October 25th
- Abstract: Abbott. A Prospective International Multicentre Cohort Study of Intraoperative Heart Rate and Systolic Blood Pressure and Myocardial Injury After Noncardiac Surgery: Results of the VISION Study. Anesth Analg 2017;epublished October 26th
- Abstract: Hayashida. Mechanical Cardiopulmonary Resuscitation and Hospital Survival Among Adult Patients With Nontraumatic Out‐of‐Hospital Cardiac Arrest Attending the Emergency Department: A Prospective, Multicenter, Observational Study in Japan (SOS‐KANTO). J Am Heart Assoc 2017;6:e007420
- Full Text: Machado. Implementation of sepsis bundles in public hospitals in Brazil: a prospective study with heterogeneous results. Critical Care 2017;21:268
- Full Text: DiGiorgio. Safety and effectiveness of early chemical deep venous thrombosis prophylaxis after spinal cord injury: pilot prospective data. Neurosurgical Focus 2017;43(5):E21
- Sinha. Unraveling the complexities of invasive multimodality neuromonitoring. Neurosurgical Focus 2017;43(5):E4
- Manfield. Real-time ultrasound-guided external ventricular drain placement: technical note. Neurosurgical Focus 2017;43(5):E5
- Tavakoli. Complications of invasive intracranial pressure monitoring devices in neurocritical care. Neurosurgical Focus 2017;43(5):E6
- Tariq. The role of ICP monitoring in meningitis. Neurosurgical Focus 2017;43(5):E7
- Kvint. Neurosurgical applications of viscoelastic hemostatic assays. Neurosurgical Focus 2017;43(5):E9
- Alotaibi. Management of raised intracranial pressure in aneurysmal subarachnoid hemorrhage: time for a consensus? E13
- Yue. Update on critical care for acute spinal cord injury in the setting of polytrauma. Neurosurgical Focus 2017;43(5):E19
- Yamamoto. Anaesthetic mechanisms in the CNS Where and how do anaesthetics act? Anaesthesiol Intensive Ther 2017;49(4):288-293
- Shenoy. Cardiovascular Oncologic Emergencies. Cardiology 2017;138:147-158
- Hahn. Adverse effects of crystalloid and colloid fluids. Anaesthesiol Intensive Ther 2017;49(4):303-308
- Hirano. Energy Failure Hypothesis for Takotsubo Cardiomyopathy. Ann Nucl Cardiol 2017;3(1):105-109
- Brixey. Innovative Cardiac Devices on Chest Imaging: An Update. J Thorac Imaging 2017;32:343–357
- Khandelwal. Pneumothorax during percutaneous tracheostomy ― a brief review of literature on attributable causes and preventable strategies. Anaesthesiol Intensive Ther 2017;49(4):317-319
- Fiore. Spontaneous peritonitis in critically ill cirrhotic patients: a diagnostic algorithm for clinicians and future perspectives. Ther Clin Risk Manag 2017;13:1409–1414
- Onichimowski. Practical issues of nutrition during continuous renal replacement therapy. Anaesthesiol Intensive Ther 2017;49(4):309-316
- Mesbah. Preoperative fasting in children. BJA Education 2017;17(10):346–350
- Mergental. Normothermic machine perfusion of the liver. Clinical Liver Disease 2017;10:97–99
- Hibi. Small-for-size syndrome in LT. Clinical Liver Disease 2017;10:93-96
- Russotto. What Healthcare Workers Should Know about Environmental Bacterial Contamination in the Intensive Care Unit. BioMed Research International 2017;(2017):6905450
- Basaran. Epidemiology and management of healthcare-associated bloodstream infections in non-neutropenic immunosuppressed patients: a review of the literature. Ther Adv Infectious Dis 2017;4(6):171–191
- Horák. Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley? Stem Cells Int 2017;2017:7304121
- Rehman. Fever after recent travel. Cleveland Clinic Journal of Medicine 2017;84(11):840-846
- Kumar. A Review of Opioid-Sparing Modalities in Perioperative Pain Management: Methods to Decrease Opioid Use Postoperatively. Anesth Analg 2017;125(5):1749-1760
- Hah. Chronic Opioid Use After Surgery: Implications for Perioperative Management in the Face of the Opioid Epidemic. Anesth Analg 2017;125(5):1733–1740
- Munyon. 2017 Update in perioperative medicine: 6 questions answered. Cleveland Clinic Journal of Medicine 2017;84(11):863-872
- Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intnsive Care Med 2017;epublished October 31st
- Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association / American Stroke Association. Stroke 2017;epublished November 2nd
- Montgomery. Frailty in the age of VIPs (very old intensive care patients). Intensive Care Med 2017;epublished October 30th
- De Jong. Focus on ventilation and airway management in the ICU. Intensive Care Med 2017;epublished October 29th
- Lin. Head position in acute stroke: an editorial on the HeadPoST trial. Journal of Emergency and Critical Care Medicine 2017;1:30
- Bruni. Mechanical ventilation in brain injured patients: seeing the forest for the trees. J Thorac Dis 2017;9(10):3483-3487
- Daganou. Should age be a criterion for intensive care unit admission in cancer patients?—Still an issue of uncertainty. J Thorac Dis 2017;9(10):3506-3508
- Edriss. What comes after the Early Goal Directed Therapy for sepsis era? J Thorac Dis 2017;9(10):3514-3517
- Wiedermann. Fluid resuscitation targeting sepsis-induced cardiovascular dysfunction: severity of disease as effect modifier. J Thorac Dis 2017;9(10):33541-3544
- Lee. The search continues: neuroprotection for all neonates with hypoxic-ischemic encephalopathy. J Thorac Dis 2017;9(10):3553-3536
- Benekli. Challenging decision: ICU admission of critically ill elderly solid tumor patients. J Thorac Dis 2017;9(10):3564-3567
- Nakatani. Are beta blockers still necessary for all survivors of acute myocardial infarction? J Thorac Dis 2017;9(10):3616-3619
- Sakamoto. Simulation-based training for handling extracorporeal membrane oxygenation emergencies. J Thorac Dis 2017;9(10):3649-3651
- Zuin. Non-intubated tracheal surgery: is it worthwhile? J Thorac Dis 2017;9(10):3663-3666
- Uranues. Laparoscopy in Abdominal Emergencies – Past and Future. Chirurgia 2017;112:509-511
- Coimbra. Massive Transfusion and Massive Transfusion Protocols. Where We Are and Where We Need to Go. Chirurgia 2017;112:512-513
- Zago. Failure to Rescue, Rescue Surgery and Centralization of Postoperative Complications: A Challenge for General and Acute Care Surgeons. Chirurgia 2017;112:538-545
- Barsky. The Iatrogenic Potential of the Physician’s Words. JAMA 2017;epublished October 31st
- Keating. The CRASH-2 randomised controlled trial: a retrospective. Lancet 2017;390(10107):2030-2031
- Emanuel. Measuring the Burden of Health Care Costs on US Families. The Affordability Index. JAMA 2017;epublished November 2nd
- Reinhardt. What Level of Health Spending Is “Affordable”? JAMA 2017;epublished November 2nd
- Antos. Challenges in Measuring the Affordability of US Health Care. JAMA 2017;epublished November 2nd
- Pisani. Lung ultrasound and neonatal ARDS: is Montreux closer to Berlin than to Kigali? Lancet 2017;5(11)e32Lung ultrasound and neonatal ARDS: is Montreux closer to Berlin than to Kigali? Lancet 2017;5(11)e31
- Manji. Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue. Case Rep Crit Care 2017;2017:8747326
It's now just over 2 months until the Critical Care Reviews Meeting 2018, where the chief investigators for the best critical care trials of 2017 come to discuss their work and try to answer the question clinicians want to know - should I change my practice based on this trial? From Brisbane, Australia, Prof Bala Ventakesh will explore the ADRENAL trial, examining hydrocortisone in septic shock in the biggest sepsis trial ever undertaken. Working between Dublin and Melbourne, Prof Alistair Nichol will explain the findings of the TRANSFUSE trial, comparing transfusion of the freshest available blood with standard issued red cells. From Nantes, France, Dr Jean-Baptiste Lascarrou will consider the findings of the MACMAN trial, evaluating video laryngoscopy in the ICU. Dr Ashish Khanna, from the Cleveland Clinic, USA, will reflect on ATHOS-3 the first large clinical trial examining angiotensin II in septic shock. Prof Gavin Perkins, from Warwick in England, will discuss his multi-centre randomized controlled trial Breathe, evaluating the role of extubation to non-invasive ventilation in patients failing spontaneous breathing trials. Prof John Simpson, from Newcastle, England, will discuss the VAP-RAPID trial, evaluating the use of a biomarker-guided approach to exclude ventilator-associated pneumonia. The final trial added to the programme is the ART Trial. Prof Alexandre Biasi Cavalcanti (São Paulo) will explain this Brazilian investigation testing alveolar recruitment in ARDS.
We also have Prof Andrew Rhodes, from London, exploring the latest iteration of the Surviving Sepsis Campaign, published earlier this year and Dr Sophie Wallace (Perth, Australia), who will deliver the honorary John Hinds Trauma Lecture, entitled "Disaster on Everest - Trauma at the Top of the World"
We sold out #CCR17 and had to turn people away. At present we are way up on registrations compared to the same time-point in 2016. So, if you intend on coming, don't leave it too late to register. There is plenty of space still at present, but I expect the meeting will sell out well before it's date of Friday January 19th. Don't worry if you can't make it, as the talks will be recorded and put online for free viewing as usual. However, there is nothing like being there in person and having the opportunity to chat with these chief investigators. Numbers are strictly limited to ensure this remains a small, intimate meeting. It would be a shame to miss out......
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
We are very pleased to announce the 6th International Fluid Academy Days (iFAD), which will take place on November 23-25th 2017 at the Hilton Hotel in Antwerp, Belgium. The iFAD is an innovative Critical Care Educational meeting in true SMACC spirit. This conference provides the highest quality of Critical Care education and is guaranteed to innovate and inspire. Recent advances in fluid management, and hemodynamic and organ function monitoring in the critical care setting will be reviewed in a comprehensive manner for intensivists, anaesthesiologists and emergency physicians as well as interested internists and surgeons.
The iFAD Faculty is the most provocative, engaging, motivating and inspiring group of international educational speakers and as organizing committee we want to ensure we have the participants, sponsors and endorsers to match. Together, we make iFAD stand apart from other Critical Care conferences.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board