Welcome to the 288th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are the REVIVE RCT, investigating an exercise programme post discharge home after critical illness, a paediatric trial examining the FAST scan in trauma, and an RCT on icatibant for ACE inhibitor-induced upper airway angioedema. In addition, there are great reviews on status epilepticus, mechanical ventilation, biomarkers in ARDS and research priorities in perioperative intensive care medicine.
As I'm lucky enough to be invited to speak at this week's annual conference of the European Veterinary Emergency and Critical Care Society, this week's Topic of the Week is Veterinary Critical Care, starting with a paper on monitoring small animal patients in the intensive care unit in tomorrow's Paper of the Day. This should prove an interesting week's reading for human medics!
The latest addition to the Critical Care Reviews Meeting 2018 programme is Dr Ashish Khanna, from the Cleveland Clinic, Ohio, USA. Dr Kanna was the lead on the ATHOS-3 trial, recently presented at the American Thoracic Society and simultaneously published in the New England Journal of Medicine. ATHOS-3 investigated angiotensin II in septic shock, opening an exciting new frontier in vasopressor therapy.
- Abstract: McDowell. Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: a randomised controlled trial (the REVIVE trial) Thorax 2017;72:594-595
- Abstract: Holmes. Effect of Abdominal Ultrasound on Clinical Care, Outcomes, and Resource Use Among Children With Blunt Torso Trauma. A Randomized Clinical Trial. JAMA 2017;317(22):2290-2296
- Full Text: Sinert. Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema. J Allergy Clin Immunol Pract 2017;epublished May 25th
- Abstract: Jeppesen. Prolonged targeted temperature management compromises thrombin generation: A randomised clinical trial. Resuscitation 2017;epublished June 7th
- Abstract: Makdee. High-Flow Nasal Cannula Versus Conventional Oxygen Therapy in Emergency Department Patients With Cardiogenic Pulmonary Edema: A Randomized Controlled Trial. Ann Emerg Med 2017;epublished June 7th
- Abstract: Chidambaram. A meta-analysis of the efficacy of whole-body computed tomography imaging in the management of trauma and injury. Injury 2017;epublished June 6th
- Abstract: Michard. Perioperative goal-directed therapy with uncalibrated pulse contour methods: impact on fluid management and postoperative outcome. Br J Anaesth 2017;epublished June 11th
- Full Text: Sun. Effect of perioperative goal-directed hemodynamic therapy on postoperative recovery following major abdominal surgery—a systematic review and meta-analysis of randomized controlled trials. Critical Care 2017;21:141
- Full Text: Oczkowski. The Use of Bowel Protocols in Critically Ill Adult Patients: A Systematic Review and Meta-Analysis. Crit Care Med 2017;45(7):e718-e726
- Abstract: Xu. Noninvasive Ventilation in Acute Hypoxemic Nonhypercapnic Respiratory Failure: A Systematic Review and Meta-Analysis. Crit Care Med 2017;45(7):e727-e733
- Abstract: Ehrmann. Contrast-associated acute kidney injury in the critically ill: systematic review and Bayesian meta-analysis. Intensive Care Med 2017;43(6):785–794
- Abstract: Zou. Early versus late initiation of renal replacement therapy impacts mortality in patients with acute kidney injury post cardiac surgery: a meta-analysis. Critical Care 2017;21:150
- Abstract: Putzu. Blood purification with continuous venovenous hemofiltration in patients with sepsis or acute respiratory distress syndrome. A systematic review and meta-analysis of randomized evidence. Minerva Anestesiol 2017;epublished June 12th
- Abstract: Lu. An Open Lung Strategy in the Management of Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Shock 2017;48(1):43–53
- Full Text: Das. Incidence proportion of acute cor pulmonale in patients with acute respiratory distress syndrome subjected to lung protective ventilation: A systematic review and meta-analysis. Indian J Crit Care Med 2017;21:364-75
- Full Text: Chelkeba. Effect of calories delivered on clinical outcomes in critically ill patients: Systemic review and meta-analysis. Indian J Crit Care Med 2017;21:376-90
- Abstract: Norman. Sepsis-Associated 30-Day Risk-Standardized Readmissions: Analysis of a Nationwide Medicare Sample. Crit Care Med 2017;45(7):1130–1137
- Abstract: Slack. Pilot Feasibility Study of Therapeutic Hypothermia for Moderate to Severe Acute Respiratory Distress Syndrome. Crit Care Med 2017;45(7):1152-1159
- Abstract: Emrath. Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis. Crit Care Med 2017;45(7):1177–1183
- Abstract: de Chambrun. The Clinical Picture of Severe Systemic Capillary-Leak Syndrome Episodes Requiring ICU Admission. Crit Care Med 2017;45(7):1216–1223
- Abstract: Tiruvoipati. Effects of Hypercapnia and Hypercapnic Acidosis on Hospital Mortality in Mechanically Ventilated Patients. Crit Care Med 2017;45(7):e649–e656
- Abstract: Otavio. New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality: A Validation and Clinical Decision-making Study. Am J Respir Crit Care Med 2017;epublished June 14th
- Abstract: Calder. Focused Assessment with Sonography for Trauma (FAST) in Children Following Blunt Abdominal Trauma: A Multi-Institutional Analysis. J Trauma Acute Care Surg 2017;epublished June 6th
- Full Text: Yeo. Safety of Surgical Tracheostomy during Extracorporeal Membrane Oxygenation. Korean J Crit Care Med 2017;32(2):197-204
- Abstract: Laffey. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study. Lancet Respir Med 2017;epublished June 14th
- Abstract: Yunos. Renal effects of an emergency department chloride-restrictive intravenous fluid strategy in patients admitted to hospital for more than 48 hours. Emerg Med Australas 2017;epublished June 8th
- Allegretti. Terlipressin versus placebo or no intervention for people with cirrhosis and hepatorenal syndrome. Cochrane Database of Systematic Reviews 2017, Issue 6. Art. No.: CD005162
- Beyar-Katz. Empirical antibiotics targeting gram-positive bacteria for the treatment of febrile neutropenic patients with cancer. Cochrane Database of Systematic Reviews 2017, Issue 6. Art. No.: CD003914
- Poblete. Status Epilepticus and Beyond: A Clinical Review of Status Epilepticus and an Update on Current Management Strategies in Super-refractory Status Epilepticus. Korean J Crit Care Med 2017;32(2):89-105
- Stoppe. Remote ischemic preconditioning in cardiac anesthesia: a review focusing on translation. Minerva Anestesiologica 2017;83(6):610-23
- Raffaele. Trends in mechanical ventilation: are we ventilating our patients in the best possible way? Breathe 2017;13:84-98
- Lichtenstein. Novel approaches to ultrasonography of the lung and pleural space: where are we now? Breathe 2017;13(2):100-111
- Capelozzi. Molecular and Immune Biomarkers in Acute Respiratory Distress Syndrome: A Perspective From Members of the Pulmonary Pathology Society. Arch Pathol Lab Med 2017;epublished June 14th
- Miller. Hypersensitivity Pneumonitis: A Perspective From Members of the Pulmonary Pathology Society. Arch Pathol Lab Med 2017;epublished June 14th
- Şentürk. Fluid management in thoracic anesthesia. Minerva Anestesiologica 2017;83(6):652-9entürk. Fluid management in thoracic anesthesia. Minerva Anestesiologica 2017;83(6):652-9
- Zamper. The role of thromboelastometry in the assessment and treatment of coagulopathy in liver transplant patients. Einstein (Sao Paulo) 2017;epublished April 20th
- Glassford. The Role of Oliguria and the Absence of Fluid Administration and Balance Information in Illness Severity Scores. Korean J Crit Care Med 2017;32(2):106-123
- Hertzberg. Acute kidney injury—an overview of diagnostic methods and clinical management. Clin Kidney J 2017;10(3):323-331
- Ó hAinmhire. Fibrotic Changes Mediating Acute Kidney Injury to Chronic Kidney Disease Transition. Nephron 2017;epublished ahead of print
- Tanaka. Nonpharmacological, Biomechanical Approaches to Control Inflammation in Acute Kidney Injury. Nephron 2017;epublished ahead of print
- Dépret. A Role of Remote Organs Effect in Acute Kidney Injury Outcome. Nephron 2017;epublished ahead of print
- Delanaye. Serum Creatinine: Not So Simple! Nephron 2017;epublished ahead of print
- Hukriede. Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury. Nephron 2017;epublished June 15th
- Lee. Role of Immune Cells in Acute Kidney Injury and Repair. Nephron 2017;;epublished June 10th
- Funder. Aldosterone and Mineralocorticoid Receptors—Physiology and Pathophysiology. Int J Mol Sci 2017;18(5):1032
- Eeles. Peri-operative blood management. Indian J Anaesth 2017;61:456-62
- Crochemore. A new era of thromboelastometry. Einstein (Sao Paulo) 2017;epublished June 12th
- Gillies. Current research priorities in perioperative intensive care medicine. Intensive Care Med 2017;epublished June 8th
- Hardavella. Top tips to deal with challenging situations: doctor–patient interactions. Breathe 2017;13(2):129-135
- Wojda. Keys to successful organ procurement: An experience-based review of clinical practices at a high-performing health-care organization. Int J Crit Illn Inj Sci 2017;7:91-100
- Zhang. Ten Basic Principles about Critical Ultrasonography: Critical Care Practitioners Need to Know. Chin Med J 2017;130:1610-4
- Bellomo. How to improve the care of patients with acute kidney injury. Intensive Care Med 2017;43(6):727-729
- de Grooth. Should we rely on trials with disease- rather than patient-oriented endpoints? Intensive Care Med 2017;epublished June 12th
- Boerma. Retinal involvement in sepsis: from the eye of the patient to the eye of the beholder. Critical Care 2017;21:148
- Mauri. Systematic assessment of advanced respiratory physiology: precision medicine entering real-life ICU? Critical Care 2017;21:143
- Tsochatzis. Diagnosis and treatment of ascites. J Hepatology 2017;67(1):184-185
- Bullen. Renal Oxygenation and Hemodynamics in Kidney Injury. Nephron 2017;epublished June 15th
- Kwong. AKI Adjudication: Do We Need It? Nephron 2017;epublished June 15th
- Mer. Core elements of general supportive care for patients with sepsis and septic shock in resource-limited settings. Intensive Care Med 2017;epublished June 15th
- Tripathy. Airway ultrasound to detect endotracheal tube cuff herniation. Indian J Anaesth 2017;61:511-2
- De Tymowski. On-line plasma lactate concentration monitoring in critically ill patients. Critical Care 2017;21:151
- Walter. Review of management in cardiotoxic overdose and efficacy of delayed intralipid use. JICS 2017;epublished June 13th
- McDonald. Strongyloides stercoralis Hyperinfection. N Engl J Med 2017;376:2376
There is just over a month until Das SMACC with just a handful of tickets remaining availabe for the main conference. If you are interested in attending the workshops, there are a very small number of tickets left for the Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong. With a superb international faculty, this half-day event will address your burning critical care questions.
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
State-of-the-Art is back, for the 3rd year of its new format and an all-new venue in Liverpool for 2017. The futurism and innovation theme continues with novel topics including robotics, optical imaging of bacterial infection, new technology in patient recovery, and new device interventions in acute cardiology.
However, the focus on day-to-day care is not lost, and there are clinical updates in acute medicine, ARDS, mechanical ventilation, trauma, nutrition, rehabilitation, endocrine management in ICU, cancer patients in ICU, the difficult and altered airway, and much more. Pragmatic "how I treat..." sessions proved popular last year and will continue, along with meaningful debates on UK critical care, including the trend toward centralisation.
In addition, the trademark vibe of SOA will still be there with pop-up talks, panel debates, 'meet the expert' booths, new generation video e-posters, parent and infant facilities, two drinks evenings, and a new final night after-party. Registration and abstract submission is now open at http://soa.ics.ac.uk.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board