Welcome to the 272nd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's issue are randomised controlled trials on hydration for the prevention of contrast-induced nephropathy & fibrinogen for high-risk cardiac surgery; guidelines on damage control resuscitation, tracheostomy in critically ill patients & parenteral nutrition; and narrative reviews on airway management, right ventricular failure post cardiac surgery, focused ultrasonography for nephrologists and a debate on protocolized early sepsis care.
Its almost four years since we last covered post cardiac arrest management as our Topic of the Week. As many of those papers are now quite old, I've updated this, starting with a paper on targeted temperature management for adult out-of-hospital cardiac arrest in tomorrow's Paper of the Day.
If you've seen presentations of the talks from previous Critical Care Reviews Meetings, but haven't yet attended, and wonder just what it's all about, then check out this short video, shot last month at #CCR17. Paul Young, who we were honoured to have speak at #CCR16, has generously decribed the event as the "best medical education meeting for ICU doctors of the year. Bar none. End of story". Registration for #CCR18 opens on April 9th, with numbers being strictly limited to keep this a small, intimate event. Critical Care Reviews is a not-for-profit organisation.
Another two talks from #CCR17 have been released this week, bringing to three the number of presentations now out. Earlier this morning, Greet Van den Berghe's talk on her PEPaNIC trial was released, with Peter Hutchinson's talk on the RESCUEicp trial out last Wednesday. There will be another two out this week - Peter Hjortrup discussing the CLASSIC trial and Gonzalo Hernandez on his high flow nasal oxygen trial.
- Abstract: Nijssen. Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial. Lancet 2017;epublished February 20th
- Abstract: Bilecen. Effect of Fibrinogen Concentrate on Intraoperative Blood Loss Among Patients With Intraoperative Bleeding During High-Risk Cardiac Surgery. A Randomized Clinical Trial. JAMA 2017;317(7):738-747
- Full Text: Mitaka. Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery–associated acute kidney injury: A multicenter randomized controlled trial. J Crit Care 2017;38:253–258
- Abstract: Mahmoodpoor. A prospective randomized trial of tapered-cuff endotracheal tubes with intermittent subglottic suctioning in preventing ventilator-associated pneumonia in critically ill patients. J Crit Care 2017;38:152–156
- Full Text: Bao. Clinical outcomes of extended versus intermittent administration of piperacillin/tazobactam for the treatment of hospital-acquired pneumonia: a randomized controlled trial. Eur J Clin Microbiol Infect Dis 2017;36(3):459-466
- Abstract: Anderson. Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study. Lancet 2017;389(10071):805–814
- Full Text: Drewry. Antipyretic Therapy in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis. Crit Care Med 2017;epublished February 17th
- Abstract: Park. The effect of early goal-directed therapy for treatment of severe sepsis or septic shock: A systemic review and meta-analysis. J Crit Care 2017;38:p115–122
- Abstract: Wei. Brain natriuretic peptide for prevention of contrast-inducednephropathy: a meta-analysis of randomized controlled trials. Eur J Clin Pharmacol 2016;72(11):1311-1318
- Abstract: Nydahl. Safety of Patient Mobilization and Rehabilitation in the ICU: Systematic Review with Meta-Analysis. Ann Am Thorac Soc 2017;epublished February 23rd
- Abstract: Xiong. Preoperative Statin Treatment for the Prevention of Acute Kidney Injury in Patients Undergoing Cardiac Surgery: A Meta-Analysis of Randomised Controlled Trials. Hear Lung Cir 2017;epublished February 12th
- Abstract: Schlapbach. Prediction of pediatric sepsis mortality within 1 h of intensive care admission. Intensive Care Med 2017;epublished February 20th
- Full Text: Kemp. Pain Assessment in INTensive care (PAINT): an observational study of physician-documented pain assessment in 45 intensive care units in the United Kingdom. Anaesthesia 2017;epublished February 19th
- Full Text: Sakr. Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit. Crit Care Med 2017;45(3):386-394
- Full Text: Leisman. Survival Benefit and Cost Savings From Compliance With a Simplified 3-Hour Sepsis Bundle in a Series of Prospective, Multisite, Observational Cohorts. Crit Care Med 2017;45(3):395-406
- Full Text: Matkovich. Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis. Crit Care Med 2017;45(3):407-414
- Full Text: Bruns. Stapled versus hand-sewn: A prospective emergency surgery study. An American Association for the Surgery of Trauma multi-institutional study. J Trauma Acute Care Surg 2017;82(3):435–443
- Abstract: McDonald. Post-contrast acute kidney injury in intensive care unit patients: a propensity score-adjusted study. Intensive Care Med 2017;epublished February 17th
- Full Text: Giraudet. Noninvasive detection of alarming intracranial pressure changes by auditory monitoring in early management of brain injury: a prospective invasive versus noninvasive study. Critical Care 2017;21:35
- Full Text: Ou. The impact of post-operative sepsis on mortality after hospital discharge among elective surgical patients: a population-based cohort study. Critical Care 2017;21:34
- Karlik. Recent trends in airway management. F1000Research 2017, 6(F1000 Faculty Rev):159
- Choudhury. Airway Management of the Cardiac Surgical Patients: Current Perspective. Ann Card Anaesth 2017;20(Suppl 1):S26–S35
- Victor. Postoperative Right Ventricular Failure in Cardiac Surgery. Cardiol Res 2016;7(6):185–195
- Conrad. Extracorporeal Membrane Oxygenation for Refractory Cardiac Arrest. Ann Card Anaesth 2017;20(Suppl 1):S4–S10
- Jayaraman. Cannulation Strategies in Adult Veno-arterial and Veno-venous Extracorporeal Membrane Oxygenation: Techniques, Limitations, and Special Considerations. Ann Card Anaesth 2017;20(Suppl 1):S11–S18
- Sreedhar. Acyanotic Congenital Heart Disease and Transesophageal Echocardiography. Ann Card Anaesth 2017;20(Suppl 1):S36–S42
- Galyfos. Pleiotropic Effects of Statins in the Perioperative Setting. Ann Card Anaesth 2017;20(Suppl 1):S43–S48
- Magoon. Pharmacological Update: New Drugs in Cardiac Practice: A Critical Appraisal. Ann Card Anaesth 2017;20(Suppl 1):S49–S56
- Choudhury. Studying Diastology with Speckle Tracking Echocardiography: The Essentials. Ann Card Anaesth 2017;20(Suppl 1):S57–S60
- Choudhury. Goldenhar Syndrome: Cardiac Anesthesiologist's Perspective. Ann Card Anaesth 2017;20(Suppl 1):S61–S66
- Lee. Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy. Int J Mol Sci 2017;18(2)
- Mehta. Percutaneous Tracheostomy. Ann Card Anaesth 2017;20(Suppl 1):S19–S25
- Alanio. Challenges in microbiological diagnosis of invasive Aspergillus infections. F1000Research 2017, 6(F1000 Faculty Rev):157
- Lutfi. The physiological basis and clinical significance of lung volume measurements. Multidisciplinary Respiratory Medicine 2017;12:3
- Kaptein. Focused Real-Time Ultrasonography for Nephrologists. International Journal of Nephrology 2017;2017:37568572017;2017:3756857
- Belpulsi. The controversy over the age of blood: what do the clinical trials really teach us? Blood Transfus 2017;15:112-5
- Arias-Morales. Revisiting blood transfusion and predictors of outcome in cardiac surgery patients: a concise perspective. F1000Research 2017, 6(F1000 Faculty Rev):168
- Zufferey. Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP). J Clin Med 2017;6(2):16
- Yataco. Protocolized Early Sepsis Care Is Not Only Helpful for Patients: It Prevents Medical Errors. Crit Care Med 2017;45(3):464-472
- Delaney. Protocolized Sepsis Care Is Not Helpful for Patients. Crit Care Med 2017;45(3):473-475
- Rupprecht. Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies. F1000Research 2017'6(F1000 Faculty Rev):184
- Cannon. Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg 2017;82(3):605-617
- Raimondi. Evidence-based guidelines for the use of tracheostomy in critically ill patients. J Crit Care 2017;38:304–318
- Worthington. When Is Parenteral Nutrition Appropriate? JPEN J Parenter Enteral Nutr 2017;epublished February 1st
- Kapoor. Echocardiography in Extracorporeal Membrane Oxygenation. Ann Card Anaesth 2017;20(Suppl 1):S1–S3
- Li. Application of Venovenous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Failure: Situations, Issues, and Trends. Chin Med J (Engl) 2017;130(5):505-507
- Wong. Intensive care medicine in 2050: precision medicine. Intensive Care Med 2017;epublished February 24th
- Mayo. Intensive Care Medicine in 2050: the future of medical imaging. Intensive Care Med 2017;epublished February 20th
- Levi. What do sepsis-induced coagulation test result abnormalities mean to intensivists?. Intensive Care Med 2017;epublished February 20th
- Darmon. Predictions are difficult…especially about AKI. Intensive Care Med 2017;epublished February 20th
- Poole. Small observational studies and data sharing: fuel for debate and coins for the piggy bank of evidence. Intensive Care Med 2017;epublished February 20th
- Merino. Standing up for science in the era of Trump. BMJ 2017;356:j775
- Various. Levosimendan in Sepsis. N Engl J Med 2017;376:798-800
- Alahdab. The US immigration ban: implications for medical education and the physician workforce. Lancet 2017;epublished February 24th
- Díaz-Lobato. High-flow nasal oxygen is not an oxygen therapy device. Rev Port Pneumol 2017;23:51-2
- Alahdab. The US immigration ban: implications for medical education and the physician workforce. Lancet 2017;epublished February 24th
There are just 4 months left unit Das SMACC and all tickets have now been sold for the main conference. If you are interested in attending the workshops, there are a very small number of tickets left for the Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong. With a superb international faculty, this half-day event will address your burning critical care questions.
The Canadian Critical Care Conference (www.canadiancriticalcare.CA; @CriticalCareCa) is rather special. Not only a spectacular location (world famous Whistler, British Columbia, Canada) but also the world's finest downhill skiing, cross-country skiing, and mountain village location (did we mention it's in Whistler?). Located at the lovely Four Seasons Resort, we offer a meeting crammed with world renown speakers but in a more laid back, interactive, and reinvigorating setting that your typical medical conference. We cover all of the core science and latest research, but do not shy away from all those topics that make for a great, or not so great, patient care. This includes human factors, burnout and resilience, end-of-life care, multidisciplinary care, social media, organ donation, and the patient perspective. We are always kean to engage trainees and nurses, we offer world class precourses, and we ensure time to enjoy all that makes Whistler and Blackcomb so special. We have no desire to be the world's largest acute care conference. Rather we want to create something unique: an opportunity to learn; to interact, to have fun, and to leave more refreshed and engaged. Come and join us on March 1st to 3rd.
(Image from Chensiyuan via Wikipedia)
The Critical Care Symposium (CCS) was initiated to satisfy the purpose of creating a world-class environment for medical enrichment in the North of England, particularly in Manchester. It was envisioned as a common informal platform wherein professionals from the field of critical care could provide and enhance the knowledge of delegates on current practices and related fields of interest.
Now in its 14th year, the annual conference regularly has renowned speakers from around the world and attracts more than 400 delegates. And this year is no different. In recent years a parallel course on ultrasound has been conducted alongside the conference that provides ample hand-on experience over two days. This year will host the 7th Ultrasound in Acute Care. For more information please visit http://critcaresymposium.co.uk.
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week