Welcome to the 258th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's newsletter are the REVIVE trial, examining rehabilitation post hospital discharge for critically ill patients, the VANCS trial, comparing vasopressin with noradrenaline in patients with vasoplegic shock post cardiac surgery and the COOLIST trial, investigating cooling in ischaemic stroke. There are also great reviews on critically ill patients with cancer, renal replacement therapies in neonates and tetanus in the elderly, as well as the latest Society of Critical Care Medicine guideline, on sustained neuromuscular blockade. If you only have time for one paper this week, try this one on the development of intensive care in the military environment.
This week's Topic of the Week is coagulopathy, starting with a paper on coagulopathy and platelet disorders in critically ill patients in tomorrow's Paper of the Day.
- Abstract: McDowell. Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: a randomised controlled trial (the REVIVE trial). Thorax 2016;epublished November 15th
- Full Text: Mehra. A Fully Magnetically Levitated Circulatory Pump for Advanced Heart Failure (MOMENTUM 3 Trial). N Engl J Med 2016;epubished November 16th
- Full Text: Eikelboom. Perioperative Aspirin for Prevention of Venous Thromboembolism: The PeriOperative ISchemia Evaluation-2 Trial and a Pooled Analysis of the Randomized Trials. Anesthesiology 2016;125:1121-1129
- Full Text: McCormick. Effectiveness of an Electronic Alert for Hypotension and Low Bispectral Index on 90-day Postoperative Mortality: A Prospective, Randomized Trial. Anesthesiology 2016;125:1113-1120
- Abstract: Royse. Impact of Methylprednisolone on Postoperative Quality of Recovery and Delirium in the Steroids in Cardiac Surgery Trial: A Randomized, Double-blind, Placebo-controlled Substudy. Anesthesiology 2016;epublished October 23rd
- Abstract: Geurts. COOLIST (Cooling for Ischemic Stroke Trial): A Multicenter, Open, Randomized, Phase II, Clinical Trial. Stroke 2017;epublished November 17th
- Abstract: Hajjar. Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock After Cardiac Surgery: The VANCS Randomized Controlled Trial. Anesthesiology 2016;epublished November 11th
- Abstract: Zhu. High flow nasal cannula oxygen therapy versus conventional oxygen therapy in cardiac surgical patients: a meta-analysis. J Crit Care 2016;epublished November 9th
- Abstract: Putzu. Vitamin D and outcomes in adult critically ill patients. A systematic review and meta-analysis of randomized trials. J Crit Care 2016;epublished November 8th
- Full Text: Liu. Dexmedetomidine versus propofol sedation reduces delirium in patients after Cardiac Surgery: A meta-analysis with trial sequential analysis of randomized controlled trials. J Crit Care 2016;epublished November 8th
- Full Text: Bi. Efficacy and Safety of Adjunctive Corticosteroids Therapy for Severe Community-Acquired Pneumonia in Adults: An Updated Systematic Review and Meta-Analysis. PLoS One 2016;11(11):e0165942
- Abstract: Sterlinga. Intravenous Beta-Blockers in ST-Segment Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis. International Journal of Cardiology 2016;epublished November 9th
- Full Text: Walia. Efficacy of Monitoring Devices in Support of Prevention of Pressure Injuries: Systematic Review and Meta-analysis. Adv Skin Wound Care 2016;29(12):567-574
- Abstract: Siew. Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness. Am J Respir Crit Care Med 2016;epublished November 17th
- Abstract: Bhatraju. Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Crit Care 2016;20(1):372
- Full Text: Metcalfe. Is there a ‘weekend effect’ in major trauma? Emerg Med J 2016;33:836-842
- Full Text: Nobile. The impact of extracerebral organ failure on outcome of patients after cardiac arrest: an observational study from the ICON database. Critical Care 2016;20:368
- Full Text: Komáromi. Simultaneous assessment of the synthesis rate and transcapillary escape rate of albumin in inflammation and surgery. Critical Care 2016;20:370
- Hodgson. Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation. Cochrane Database of Systematic Reviews 2016, Issue 11. Art. No.: CD006667
- Lewis. Videolaryngoscopy versus direct laryngoscopy for adult patients requiring tracheal intubation. Cochrane Database of Systematic Reviews 2016, Issue 11. Art. No.: CD011136
- Pritchard. Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain-Barré syndrome. Cochrane Database of Systematic Reviews 2016, Issue 11. Art. No.: CD008630
- Motta. Importance of the use of protocols for the management of analgesia and sedation in pediatric intensive care unit. Rev Assoc Med Bras 2016;62(6):602-609
- Okada. The pathophysiological role of acute inflammation after spinal cord injury. Inflammation and Regeneration 2016;36:20
- Oh. Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review. Korean J Neurotrauma 2016;12(2):40-46
- Benedek. Extracorporeal Life Support and New Therapeutic Strategies for Cardiac Arrest Caused by Acute Myocardial Infarction - a Critical Approach for a Critical Condition. The Journal of Critical Care Medicine 2016;2(4):164-174
- Koratala. Extracorporeal Ultrafiltration for Acute Heart Failure: Lost Battle or Lasting Opportunity. Blood Purif 2017;43:1-10
- Hendy. The Diagnosis and Hemodynamic Monitoring of Circulatory Shock: Current and Future Trends. The Journal of Critical Care Medicine 2016;2(3):115-123
- Yamakawa. Heart regeneration for clinical application update 2016: from induced pluripotent stem cells to direct cardiac reprogramming. Inflammation and Regeneration 2016;36:23
- Chauhan. Nasal intubation: A comprehensive review. Indian J Crit Care Med 2016;20:662-7
- Scala. Challenges on non-invasive ventilation to treat acute respiratory failure in the elderly. BMC Pulmonary Medicine 2016;16:150
- Rees. Renal replacement therapies in neonates: Issues and ethics. Seminars in Fetal & Neonatal Medicine 2016;epublished November 11th
- Kashani. Acute Kidney Injury Electronic Alert for Nephrologist: Reactive versus Proactive. Blood Purif 2016;42:323-328
- Rawal. Anemia in Intensive Care: A review of Current Concepts. The Journal of Critical Care Medicine 2016;2(3):109-114
- Scarlatescu. Sepsis-Associated Coagulopathy. The Journal of Critical Care Medicine 2016;2(2):156-163
- Isono. Tetanus in the Elderly: The Management of Intensive Care and Prolonged Hospitalization. Internal Medicine 2016;55(22):3399-3402
- Roberts. The Development of Intensive Care in the Military Environment. Journal of Anaesthesia History 2016;2(4):133–141
- Murray. Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient. Crit Care Med 2016;44(11):2079-2103
- Allegranzi. New WHO recommendations on preoperative measures for surgical site infection prevention: an evidence-based global perspective. Lancet Infect Dis 2016;16(12):e276–e287
- Allegranzi. New WHO recommendations on intraoperative and postoperative measures for surgical site infection prevention: an evidence-based global perspective. Lancet Infect Dis 2016;16(12):e288–e303
- Poulakou. Planet’s population on the move, infections on the rise. Intensive Care Med 2016;42(12):2055–2058
- Darmaros. Corticosteroids in septic shock: What should the decision in pediatrics be? Rev Assoc Med Bras 2016;62(6):482-484
- Kazory. More Efficient Sodium Removal by Ultrafiltration Compared to Diuretics in Acute Heart Failure; Underexplored and Overstated. Blood Purif 2016;42:279-281
- Aneman. Arteriovenous extracorporeal membrane oxygenation for cardiac arrest/cardiogenic shock. Intensive Care Med 2016;epublished November 15th
- Ball. High-flow nasal cannula in the postoperative period: is positive pressure the phantom of the OPERA trial? Intensive Care Med 2016;epublished November 16th
- Rojas-Gómez. Perioperative Ultrasound: The challenge of applying an old technology in new clinical settings. Rev Colomb Anestesiol 2016;44:267-9
- Ionescu. Have Severity Scores a Place in Predicting Septic Complications in ICU Multiple Trauma Patients? The Journal of Critical Care Medicine 2016;2(3):107-108
- Pappachan. Paediatric cardiopulmonary bypass surgery: the challenges of heterogeneity and identifying a meaningful endpoint for clinical trials. Intensive Care Med 2016;epublished November 18th
- Kannan. Abandoning cricoid pressure. Anaesthesia 2016;71:1488
- Levy. Cricoid pressure and the law. Anaesthesia 2016;71:1488–1489
- Turnbull. Abandoning cricoid pressure – a reply. Anaesthesia 2016;71:1489–1490
- Rodríguez-Rodríguez. The utility of biomarkers in traumatic brain injury clinical management. Critical Care 2016;20:376
- Al Bshabshe. Diagnosis of a missed central line guidewire using critical care ultrasound. Indian J Crit Care Med 2016;20:677-9
- Ash. Seldinger Technique for Placement of "Peripheral" Internal Jugular Line: Novel Approach for Emergent Vascular Access. West J Emerg Med 2016;17(1):81-3
- Yamaoka. Cerebral air embolism associated with penetrating lung injury: a case report and review of the literature. Acute Med Surg 2016;epublished November 10th
- Tavazzi. Invasive pulmonary aspergillosis after near-drowning. Lancet Infect Dis 2016;16(12):1430
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
The first release of tickets for Das SMACC sold out in just 2.5 hours this week. The next opportunity will be on Wednesday December 7th (depending on where you are in the world). If you haven't yet checked out the programme and workshops, then have a look on the SMACC website. The Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong will cover all your critical care questions.
(Image from Chensiyuan via Wikipedia)
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week