Just 3 months to #CCR17 - Fireworks Guaranteed
Welcome to the 254th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlight of this week's issue is the OPERA randomised controlled trial, investigating high-flow nasal oxygen post abdominal surgery. If you only have time for one review article this week, try this paper on the hazards of intubation in the ICU
In response to a fascinating study epublished this week in the Blue Journal, on partial neuromuscular blockade during partial ventilatory support in sedated patients with high tidal volumes, this week's Topic of the Week is spontaneous breathing during mechanical ventilation, starting with a paper on the role of spontaneous effort during mechanical ventilation in tomorrow's Paper of the Day.
I have two meeting reminders; firstly, das SMACC opens for registration this Tuesday / Wednesday, depending on where you are in the world. Tickets will sell out immediately, so be ready! Also, the early bird rate for the Intensive Care Society's State-of-the-Art Meeting this December 5th to 7th, closes tomorrow October 24th.
In other news, the University of Cambridge Master of Studies in Intensive Care Medicine is available again. This is a two year combined clinical and academic training scheme in Cambridge for aspiring tertiary centre intensive care medicine consultants. It comprises a one-year Postgraduate Certificate course, a two-year Master of Studies (MSt) and a two year course on Healthcare Education Leadership and Management. This Clinical Medicine Programme will enhance the specialist training of senior intensivists in training and broaden their understanding of healthcare education, research, leadership and management. Applicantions and further information are available here.
Finally, Ed Litton, Chief Investigator for the just published IRONMAN Study, is raising funds for the ANZICS Intensive Care Foundation by cycling an incredible 4000 km across Australia. You can support his fund raising activities here.
- Abstract: Futier. Effect of early postextubation high-flow nasal cannula vs conventional oxygen therapy on hypoxaemia in patients after major abdominal surgery: a French multicentre randomised controlled trial (OPERA). Intensive Care Med 2016;epublished October 22nd
- Abstract: Semler. Balanced Crystalloids versus Saline in the Intensive Care Unit: The SALT Randomized Trial. Am J Respir Crit Care Med 201;epublished October 17th
- Full Text: Fraga. N-acetylcysteine plus deferoxamine for patients with prolonged hypotension does not decrease acute kidney injury incidence: a double blind, randomized, placebo-controlled trial. Critical Care 2016;20:331
- Abstract: Muir. Endovascular therapy for acute ischaemic stroke: the Pragmatic Ischaemic Stroke Thrombectomy Evaluation (PISTE) randomised, controlled trial. J Neurol Neurosurg Psychiatry 2016;epublished October 18th
- Abstract: Cao. Volume-Targeted Versus Pressure-Limited Noninvasive Ventilation in Subjects With Acute Hypercapnic Respiratory Failure: A Multicenter Randomized Controlled Trial. Respir Care 2016;epublished October 18th
- Abstract: Wu. Low-dose Dexmedetomidine Improves Sleep Quality Pattern in Elderly Patients after Noncardiac Surgery in the Intensive Care Unit: A Pilot Randomized Controlled Trial. Anesthesiology 2016;125:979-991
- Abstract: Puckett. Low Versus Standard Urine Output Targets in Patients Undergoing Major Abdominal Surgery: A Randomized Noninferiority Trial. Ann Surg 2016;epublished October 19th
- Abstract: Cayla. Platelet function monitoring to adjust antiplatelet therapy in elderly patients stented for an acute coronary syndrome (ANTARCTIC): an open-label, blinded-endpoint, randomised controlled superiority trial. Lancet 2016;388(10055):2015–2022
- Abstract: Weng. Randomised trials of vitamin D3 for critically ill patients in adults: systematic review and meta-analysis with trial sequential analysis. Intensive Care Medicine 2016;epublished October 19th
- Abstract: Sklar. Effort To Breathe With Various Spontaneous Breathing Trial Techniques. A Physiological Meta-analysis. Am J Respir Crit Care Med 2016;epublished October 21st
- Abstract: de Azevedo. Cerebral hemodynamics in sepsis assessed by transcranial Doppler: a systematic review and meta-analysis. J Clin Monit Comput 2016;epublished October 18th
- Abstract: Som. Goal directed fluid therapy decreases postoperative morbidity but not mortality in major non-cardiac surgery: a meta-analysis and trial sequential analysis of randomized controlled trials. J Anesth 2016;epublished October 13th
- Abstract: Streib. Early decompressive craniectomy for malignant cerebral infarction: Meta-analysis and clinical decision algorithm. Neurol Clin Pract 2016;6:433-443
- Abstract: Millin. Patients without ST elevation after return of spontaneous circulation may benefit from emergent percutaneous intervention: A systematic review and meta-analysis. Resuscitation 2016;108:54–60
- Abstract: Schenone. Therapeutic hypothermia after cardiac arrest: A systematic review/meta-analysis exploring the impact of expanded criteria and targeted temperature. Resuscitation 2016;108:102–110
- Abstract: Laffey. Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study. Intensive Care Med 2016;epublished October 18th
- Abstract: Doorduin. Partial Neuromuscular Blockade During Partial Ventilatory Support in Sedated Patients with High Tidal Volumes. Am J Respir Crit Care Med 201;epublished October 17th
- Abstract: Bellani. Non-invasive Ventilation of Patients with ARDS: Insights from the LUNG SAFE Study. Am J Respir Crit Care Med 2016;epublished October 18th
- Abstract: Wellman. Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity. Anesthesiology 2016;125:992-1004
- Full Text: Torres. Outcomes in Critically Ill Patients with Cancer-Related Complications. PLoS One 2016;11(10):e0164537
- Farag. Therapeutic Hypothermia And Neuroprotection. Anesthesiology News 2016;epublished October 18th
- Moreira. Sedation in mechanically ventilated patients—time to stay awake? Ann Transl Med 2016;4(19):382
- Morrissey. Echo for diastology. Ann Card Anaesth 2016;19, Suppl S1:12-8
- Sanjay. Perioperative management of left ventricular assist devices. Ann Card Anaesth 2016;19, Suppl S1:19-20
- Bhatia. Transesophageal echocardiography evaluation of tricuspid and pulmonic valves. Ann Card Anaesth 2016;19, Suppl S1:21-5
- Chengode. Left ventricular global systolic function assessment by echocardiography. Ann Card Anaesth 2016;19, Suppl S1:26-34
- Vegas. Three-dimensional transesophageal echocardiography: Principles and clinical applications. Ann Card Anaesth 2016;19, Suppl S1:35-43
- Patil. Transesophageal echocardiography evaluation of the thoracic aorta. Ann Card Anaesth 2016;19, Suppl S1:44-55
- Kapoor. An update on transesophageal echocardiography views 2016: 2D versus 3D tee views. Ann Card Anaesth 2016;19, Suppl S1:56-72
- Muralidhar. Guidelines of the Indian Association of Cardiovascular and Thoracic Anaesthesiologists and Indian College of Cardiac Anaesthesia for perioperative transesophageal echocardiography fellowship examination. Ann Card Anaesth 2016;19, Suppl S1:73-8
- Jayaprasad. Heart failure in children. Heart Views 2016;17:92-9
- Tasoulis. Hypoxemic reperfusion of ischemic states: an alternative approach for the attenuation of oxidative stress mediated reperfusion injury. J Biomed Sci. 2016 Jan 19;23:7
- Ricard. Hazards of intubation in the ICU: role of nasal high flow oxygen therapy for preoxygenation and apneic oxygenation to prevent desaturation. Minerva Anestesiologica 2016 October;82(10):1098-106
- Mauri. Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives. Intensive Care Med 2016;42:1360
- Shah. Novel Perioperative Utilities of the Newer Co-Oximetery Parameters: A Practical Review. EC Anaesthesia 2016;2(5):205-211
- Liu. Early Predictors of Acute Kidney Injury: A Narrative Review. Kidney Blood Press Res 2016;41(5):680-700
- Honore. Biomarkers in critical illness: have we made progress? International Journal of Nephrology and Renovascular Disease 2016;9:253—256
- Gomes. Anti-Inflammatory Cytokines in Sepsis: Immunological Studies and In Silico Investigation. J Pharma Care Health Sys 2016;3:3
- Velissaris. The Use of Pulmonary Artery Catheter in Sepsis Patients: A Literature Review. J Clin Med Res. 2016;8(11):769-776
- Restrepo-Álvarez. Trauma severity scores. Rev Colomb Anestesiol 2016;44:317-23
- Lewis. Prehospital point-of-care lactate following trauma: A systematic review. J Trauma Acute Care Surg 2016;81(4):748-755
- Satoh. 2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition). Endocr J 2016;epublished October 15th
- Ye. Therapeutic drug monitoring of vancomycin: a guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society. J Antimicrob Chemother 2016;71(11):3020-3025
- Lipsky. Antimicrobial stewardship in wound care: a Position Paper from the British Society for Antimicrobial Chemotherapy and European Wound Management Association. J Antimicrob Chemother 2016;71 (11):3026-3035
- Hu. Consensus development of core competencies in intensive and critical care medicine training in China. Critical Care 2016;20:330
- Statins in patients with sepsis and ARDS: is it over?
- Kaur. Role of sepsis in delayed mortality. Ann Transl Med 2016;4(19):378
- Rojas-Góme. Perioperative Ultrasound: The challenge of applying an old technology in new clinical settings. Rev Colomb Anestesiol 2016;44:267-9
- Devarajan. Sepsis-associated acute kidney injury – is it possible to move the needle against this syndrome? Jornal de Pediatria 2016;epublished October 13th
- Giacalone. Impact of age on anaesthesiologists’ competence: A narrative review. Eur J Anaesthesiol 2016; 33:787–793
- Lenihan. Anesthesia for Consent in Anaesthesia; An Irish Perspective. EC Anaesthesia 2016;2(5):217-220
- Muralidhar. Utility of perioperative transesophageal echocardiography. Ann Card Anaesth 2016;19, Suppl S1:2-5
- Singr. What’s on tablet PC: an introduction to FOAM at home. Clin Exp Emerg Med 2016;3(3):181-182
- Grock. Free open access medical education: a critical appraisal of techniques for quality assessment and content discovery. Clin Exp Emerg Med 2016;3(3):183-185
- Fleming. Evidence of spin in clinical trials in the surgical literature. Ann Transl Med 2016;4(19):385
- Ergul. A rare cause of refractory hyponatremia after traumatic brain injury: Acute post-traumatic hypopituitarism due to pituitary stalk transection. J Acute Med 2016;epublished October 15th
- Dobarro. A Three-in-one Snapshot of the Modern Management of Heart Failure. Rev Esp Cardiol 2016;
- Shrestha. Sinusoid sign. Bangladesh Crit Care J 2016;4(2):131
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
Registration for Das SMACC opens this Tuesday / Wednesday night, depending on where you are in the world. Tickets will sell out immediately, so be ready!
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week