PEPTIC Study Podcast with Shay McGuinness
Welcome to the 253rd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlight of this week's edition is a meta analyses from a friend and colleague in Belfast, Jon Silversides, on the role of deresuscitation in critical care. You hear more of this RADAR project as the trial team start planning the follow up RCT. There are loads of guidelines out this week, including the latest guidance from the American Association of Blood Banks on red cell transfusion thresholds. On the same topic, there is also a Cochrane Review on transfusion thresholds, which makes for an interesting comparison. If you only have time for one review article this week, try this paper on chronic critical illness.
The latest podcast, discussing the PEPTIC study on stress ulcer prophylaxis with Shay McGuinness from Auckland is now out also.
In other news, The University of Cambridge Master of Studies in Intensive Care Medicine is available again. This is a two year combined clinical and academic training scheme in Cambridge for aspiring tertiary centre intensive care medicine consultants. It comprises a one-year Postgraduate Certificate course, a two-year Master of Studies (MSt) and a two year course on Healthcare Education Leadership and Management. This Clinical Medicine Programme will enhance the specialist training of senior intensivists in training and broaden their understanding of healthcare education, research, leadership and management. Applicantions and further information are available here.
Finally, I've attached a flyer for #CCR17. If you think your colleagues might be interested in attending this superb one-day meeting, please forward this around your department. This is a not-for-profit event.
- Abstract: Jaber. Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit: the single-centre, blinded, randomised controlled OPTINIV trial. Intensive Care Med 2016;epublished October 11th
- Full Text: Tongyoo. Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial. Critical Care 2016;20:329
- Abstract: Jolliet. A Multicenter Randomized Trial Assessing the Efficacy of Helium/Oxygen in Severe Exacerbations of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2016;epublished October 13th
- Abstract: Günther. Complications of intravascular catheters in ICU: definitions, incidence and severity. A randomized controlled trial comparing usual transparent dressings versus new-generation dressings (the ADVANCED study). Intensive Care Med 2016;epublished October 12th
- Full Text: The PREVAIL II Writing Group. A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection (PREVAIL II Study). N Engl J Med 2016;375:1448-1456
- Abstract: Silversides. Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysis. Intensive Care Med 2016;epublished October 12th
- Abstract: Mohananey. Effect of antiplatelet therapy on mortality and acute lung injury in critically ill patients: A systematic review and meta-analysis. Ann Card Anaesth 2016;;19(4):626-637
- Full Text: Veigas. A systematic review on the rotational thrombelastometry (ROTEM®) values for the diagnosis of coagulopathy, prediction and guidance of blood transfusion and prediction of mortality in trauma patients. Scand J Trauma Resusc Emerg Med 2016;24(1):114
- Abstract: Vallabhajosyula. Role of Statins in Delirium Prevention in Critical Ill and Cardiac Surgery Patients: A Systematic Review and Meta-Analysis. J Crit Care 2016;epublished October 8th
- Abstract: Cochi. Mortality Trends of Acute Respiratory Distress Syndrome in the United States from 1999 to 2013. Annals ATS 2016;13(10):1742-1751
- Abstract: Vail. Epidemiology of Vasopressin Use for Adults with Septic Shock. Annals ATS 2016;13(10):1760-1767
- Full Text: Wiewel. Risk factors, host response and outcome of hypothermic sepsis. Critical Care 2016;20:328
- Full Text: Genbrugge. What is the value of regional cerebral saturation in post-cardiac arrest patients? A prospective observational study. Critical Care 2016;20:327
- Full Text: Puntillo. Patient Recollection of ICU Procedural Pain and Post ICU Burden: The Memory Study. Crit Care Med 2016;4(11):1988-1995
- Francoeur. Management of delayed cerebral ischemia after subarachnoid hemorrhage. Critical Care 2016;20:277
- Yu. Remifentanil tolerance and hyperalgesia: short-term gain, long-term pain?. Anaesthesia 2016;71:1347–1362
- Hsuan. Mesenchymal stem cell-based treatments for stroke, neural trauma, and heat stroke. Brain and Behavior 2016;6:1–11
- Lionel. Seizures - just the tip of the iceberg: Critical care management of super-refractory status epilepticus. Indian J Crit Care Med 2016;20:587-92
- Di Nardo. ECLS in Pediatric Cardiac Patients. Front. Pediatr 2016;4:109
- Lv. Pathophysiology of sepsis-induced myocardial dysfunction. Mil Med Res 2016;3:30
- Dieleman. Corticosteroids for cardiac surgery: a summary of two large randomised trials. Neth J Crit Care September 2016;24(5):6-10
- Hemph. Helium-oxygen mixture for treatment in upper airway obstruction; a mini-review. Journal of Acute Medicine 2016;epublished October 13th
- Jörres. Acute kidney injury. Minerva Urol Nefrol 2016;68(1):47-8
- da Silva. Type 4 cardiorenal syndrome. Rev Port Cardiol 2016;epublished October 3rd
- Neri. Nomenclature for renal replacement therapy in acute kidney injury: basic principles. Crit Care 2016;20(1):318
- Villa. Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications. Critical Care 2016;20:283
- Zilahi. What’s new in multidrug-resistant pathogens in the ICU? Annals of Intensive Care 2016;6:96
- Zhang. Vasoactive agents for the treatment of sepsis. Ann Transl Med 2016;4(17):333
- Jozwiak. Implementing sepsis bundles. Ann Transl Med 2016;4(17):332
- De La Rica. Epidemiologic trends of sepsis in western countries. Ann Transl Med 2016;4(17):325
- Liao. Current epidemiology of sepsis in mainland China. Ann Transl Med 2016;4(17):324
- Cag. Resistance mechanisms. Ann Transl Med 2016;4(17):326
- Encina. The immunocompromised oncohematological critically ill patient: considerations in severe infections. Ann Transl Med 2016;4(17):327
- Giamarellos-Bourboulis. The role of genetics and antibodies in sepsis. Ann Transl Med 2016;4(17):328
- Valenzuela-Sánchez. New role of biomarkers: mid-regional pro-adrenomedullin, the biomarker of organ failure. Ann Transl Med 2016;4(17):329
- Lagunes. Current understanding in source control management in septic shock patients: a review. Ann Transl Med 2016;4(17):330
- Alp. Right first time! Ann Transl Med 2016;(17):331
- Jozwiak. Implementing sepsis bundles. Ann Transl Med 2016;4(17):332
- Osthof. Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal. Swiss Med Wkly 2016;146:w14368
- Desarmenien. The chronic critical illness: a new disease in intensive care. Swiss Med Wkly 2016;146:w14336
- Chambliss. Precision medicine: from pharmacogenomics to pharmacoproteomics. Clin Proteomics 2016;13:25
- Aggarwal. Common pitfalls in statistical analysis: The use of correlation techniques. Perspect Clin Res 2016;7:187-90
- Eriksson. The false academy: predatory publishing in science and bioethics. Med Health Care and Philos 2016;epublished October 7th
- Liu. The Content of Statistical Requirements for Authors in Biomedical Research Journals. Chin Med J 2016;129:2491-6
- Zhang. Case-crossover design and its implementation in R. Ann Transl Med 2016;4(18):341
- Keeling. Peri-operative management of anticoagulation and antiplatelet therapy. Br J Haematol 2016;epublished October 7th
- Kon. Defining Futile and Potentially Inappropriate Interventions: A Policy Statement From the Society of Critical Care Medicine Ethics Committee. Crit Care Med 2016;44(9):1769–1774
- Frontera. Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage. A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine. Neurocrit Care 2016;24:6–46
- Piepho. S1 guidelines on airway management. Guideline of the German Society of Anesthesiology and Intensive Care Medicine. Der Anaesthesist 2015;64( Supplement 1):27–40
- Bein. S2e guideline: positioning and early mobilisation in prophylaxis or therapy of pulmonary disorders : Revision 2015: S2e guideline of the German Society of Anaesthesiology and Intensive Care Medicine (DGAI). Anaesthesist 2015;64 Suppl 1:1-26
- Carson. Clinical Practice Guidelines From the AABB Red Blood Cell Transfusion Thresholds and Storage. JAMA 2016;epublished October 12th
- Simon. Are ethical norms and current policies still relevant in face of the recent mass terror events? Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2016;24:118
- Beesley. Glucose management in the intensive care unit: are we looking for the right sweet spot? Ann Transl Med 2016;4(18):347
- Kaziani. Improving diagnostic accuracy for invasive pulmonary aspergillosis in the intensive care unit. Ann Transl Med 2016;4(18):352
- Zakhary. Do we really need more intensive care unit beds? Ann Transl Med 2016;4(18):356
- Jacobi. Liberal glucose targets for critically ill diabetic patients: is it time for large clinical trials with more personalized endpoints? Ann Transl Med 2016;4(18):358
- Longhini. Non-invasive ventilation in hypoxemic patients: does the interface make a difference? Ann Transl Med 2016;4(18):359
- Mayr. Understanding the complex host response in sepsis: is diabetes the key? Critical Care 2016;20:321
- Drazen. Hearing without Listening. N Engl J Med 2016;375:1412-1413
- Carron. A new horizon for the use of non-invasive ventilation in patients with acute respiratory distress syndrome. Ann Transl Med 2016;4(18):348
- Sehgal. Non-invasive ventilation in acute respiratory distress syndrome: helmet use saves lives? Ann Transl Med 2016;4(18):349
- Kacmarek. Noninvasive ventilatory management of the acute respiratory distress syndrome: a new era or just another tease! Ann Transl Med 2016;4(18):350
- Coudroy. Should we carry out noninvasive ventilation using a helmet in acute respiratory distress syndrome? Ann Transl Med 2016;4(18):351
- Honore. Timing of renal replacement therapy in critically ill patients: where are the hands on the clock? Ann Transl Med 2016;4(18):354
- Sikri. A rare case of movement disorder in Intensive Care Unit. Indian J Crit Care Med 2016;20:605-7
- Voorhuis. An acute and life-threatening complication after an endoscopic procedure. Neth J Crit Care 2016;24(5):16-7
- Biemans. Thyrotoxic hypokalaemic periodic paralysis in a Caucasian man who had already started treatment for hyperthyroidism. Neth J Crit Care 2016;24(5):18-20
- Eikemans. Early lactic acidosis after acetaminophen overdose. Neth J Crit Care 2016;24(5):21-3
- Nuzzo. Reversible Acute Mesenteric Ischemia. N Engl J Med 2016;375:e31
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
The programme is now out for Das SMACC and registration opens on October 26th at 8am Sydney time. Follow the countdown clock to registration on the SMACC website so you don't miss out. Tickets will sell out in minutes.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week