Welcome to the 251st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a huge newsletter containing a large number of great trials which have been published in Intensive Care Medicine immediately before the annual ESICM Congress in Milan.
The CLASSIC trial, being discussed at #CCR17, has just been published, while LEOPARDS, also on the programme at the Titanic Centre, will be presented on Wednesday. Most of these trials will be included in the Critical Care Reviews Book 2017, which will be available as a free download on the website. The release date is Friday, January 27th, the day of the Critical Care Reviews Meeting 2017. If you prefer a print version, There will also be an opportunity to buy this too. If you want to live stream some of the sessions from ESICM, the links are available here. The main clinical trials session is on Wednesday afternoon, with a shorter session on late Tuesday afternoon.
The other big news this week is the addition of Prof Peter Hutchinson, from Cambridge, England, the Chief Investigator of the very recently published RESCUEicp trial on decompressive craniectomy. If you want to attend the most up-to-date trials review meeting around, head to Belfast next January. Registration is open. Critical Care Reviews is a not-for-profit organisation.
There are three great papers this week on burns from the Lancet, which form part of the selection for This week's Topic of the Week on smoke inhalation, starting with a paper on the pathophysiology, research challenges, and clinical management of smoke inhalation injury in tomorrow's Paper of the Day.
- Abstract: Hjortrup. Restricting volumes of resuscitation fluid in adults with septic shock after initial management: the CLASSIC randomised, parallel-group, multicentre feasibility trial. Intensive Care Med 2016;epublished September 30th
- Abstract: James. Nitric oxide administration during paediatric cardiopulmonary bypass: a randomised controlled trial. Intensive Care Med 2016;epublished September 30th
- Abstract: Demoule. Neurally adjusted ventilatory assist as an alternative to pressure support ventilation in adults: a French multicentre randomized trial. Intensive Care Med 2016;epublished September 30th
- Abstract: Rygård. Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold: the TRISS randomised, multicentre clinical trial. Intensive Care Med 2016;epublished September 30th
- Abstract: Litton. Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial. Intensive Care Med 2016;epublished September 30th
- Abstract: Jensen. A recovery program to improve quality of life, sense of coherence and psychological health in ICU survivors: a multicenter randomized controlled trial, the RAPIT study. Intensive Care Med 2016;epublished September 30th
- Abstract: Burad. Comparison of conventional and ultrasound guided techniques of radial artery cannulation in different haemodynamic subsets: a randomised controlled study. Intensive Care Med 2016;epublished September 29th
- Abstract: Schaller. Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial. Lancet 2016;388(10052):1377–1388
- Abstract: Ramaswamy. Double-Blind Randomized Clinical Trial Comparing Dopamine and Epinephrine in Pediatric Fluid-Refractory Hypotensive Septic Shock. Pediatr Crit Care Med 2016;epublished September 23rd
- Abstract: Zhi. "Obesity Paradox" in Acute Respiratory Distress Syndrome: Asystematic Review and Meta-Analysis. PLoS One 2016;11(9):e0163677
- Abstract: Yatabe. The optimal target for acute glycemic control in critically ill patients: a network meta-analysis. Intensive Care Med 2016;epublished September 29th
- Full Text: Saver. Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis. JAMA 2016;316(12):1279-1288
- Full Text: Abdelhamid. Stress hyperglycaemia in critically ill patients and the subsequent risk of diabetes: a systematic review and meta-analysis. Critical Care 2016;20:301
- Abstract: SepNet Critical Care Trials Group. Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study. Intensive Care Med 2016;epublished September 29th
- Abstract: Zampieri. The effects of performance status one week before hospital admission on the outcomes of critically ill patients. Intensive Care Med 2016;epublished September 29th
- Abstract: de Chambrun. Venoarterial extracorporeal membrane oxygenation for refractory cardiogenic shock post-cardiac arrest. Intensive Care Med 2016;epublished September 28th
- Abstract: Luo. Clinical predictors of hospital mortality differ between direct and indirect acute respiratory distress syndrome. Chest 2016;epublished September 20th
- Full Text: Spadaro. Can diaphragmatic ultrasonography performed during the T-tube trial predict weaning failure? The role of diaphragmatic rapid shallow breathing index. Critical Care 2016;20:305
- Peters. Study protocol for a multicentre randomised controlled trial: Safety, Tolerability, efficacy and quality of life Of a human recombinant alkaline Phosphatase in patients with sepsis-associated Acute Kidney Injury (STOP-AKI). BMJ Open 2016;6:e012371
- Muscedere. Prevention of nosocomial infections in critically ill patients with lactoferrin (PREVAIL study): study protocol for a randomized controlled trial. Trials 2016;17(1):474
- Mittal. Role of isolated ultrafiltration in the management of chronic refractory and acute decompensated heart failure. Hemodialysis International 2016;20:S30–S39
- Parthasarathy. Anesthetic management of intestinal obstruction: A postgraduate educational review. Anesth Essays Res 2016;10:397-401
- Shaikh. Postoperative nausea and vomiting: A simple yet complex problem. Anesth Essays Res 2016;10:388-96
- Ostermann. Acute kidney injury 2016: diagnosis and diagnostic workup. Critical Care 2016;20:299
- Selby. International Criteria for Acute Kidney Injury: Advantages and Remaining Challenges. PLoS Med 2016;13(9):e1002122
- Andreucci. The potential use of biomarkers in predicting contrast-induced acute kidney injury. Int J Nephrol Renovasc Dis 2016;9:205–221
- Bakchoul. Protamine (heparin)-induced thrombocytopenia: a review of the serological and clinical features associated with anti-protamine/heparin antibodies. J Thromb Haemost 2016; 14: 1685–95
- Dronkers. Current and future perspectives in imaging of venous thromboembolism. J Thromb Haemost 2016; 14: 1696–710
- Lipinska-Gediga. Sepsis and septic shock-is a microcirculation a main player? Anaesthesiology Intensive Therapy 2016;epublished September 21st
- Schroeder. Macrolide Resistance in Streptococcus pneumoniae. Front Cell Infect Microbiol 2016;epublished September 21st
- Feldman. Epidemiology, virulence factors and management of the pneumococcus. F1000Research 2016, 5(F1000 Faculty Rev):2320
- Wilcox. Role of cephalosporins in the era of Clostridium difficile infection. J Antimicrob Chemother 2016;epublished September 22nd
- Porter. The metabolic stress response to burn trauma: current understanding and therapies. Lancet 2016;388(10052):1417–1426
- Finnerty. Hypertrophic scarring: the greatest unmet challenge after burn injury. Lancet 2016;388(10052):1427–1436
- Enkhbaatar. Pathophysiology, research challenges, and clinical management of smoke inhalation injury. Lancet 2016;388(10052):1437–1446
American Journal of Respiratory & Critical Care Medicine
- Moerer. Low-Flow Extracorporeal Carbon Dioxide Removal. Moving Closer to Reality. Am J Respir Crit Care Med 2015;192(6):651-652
- Tavazzi. Right Ventricular Arrhythmogenic Dysplasia in Cardiac Arrest. An Echocardiographic Pattern Not to Forget. Am J Respir Crit Care Med 2015;192(6):e46-e48
- Walkey. Optimizing Atrial Fibrillation Management: From ICU and Beyond. Chest 2015;148(4):859-864
- Palakshappa. Which Patients With ARDS Benefit From Lung Biopsy? Chest 2015;148(4):1073-1082
- Kalpalatha. Critical Illness in Pregnancy: Part I: An Approach to a Pregnant Patient in the ICU and Common Obstetric Disorders. Chest 2015;148(4):1093-1104
- Greenstein. A Man in His 50s With Septic Shock From an Occult Source. Chest 2015;148(4):e109-e111
- Albores. A 44-Year-Old Man With Bilateral Pneumothorax. Chest 2015;148(4):e118-e12
- Rathmell. Unraveling the Neurobiology of Consciousness: Anesthesia, Loss of Behavioral Response to Stimuli, and Functional Connectivity in the Brain. Anesthesiology 2016;124:A21
- Kayashima. Ultrasonographic Images of Internal Jugular Vein Duplication. Anesthesiology 2016;124:958
- Adler. Bedside Ultrasound: A Tool for Assessment of IV Functionality. Anesthesiology 2016;124:959
Anesthesia & Analgesia
- Sessler. Clinical Research Methodology 1: Study Designs and Methodologic Sources of Error. Anesth Analg 2015;121(4):1034-1042
- Sessler. Clinical Research Methodology 2: Observational Clinical Research. Anesth Analg 2015;121(4):1043-1051
- Sessler. Clinical Research Methodology 3: Randomized Controlled Trials. Anesth Analg 2015;121(4):1052-1064
- Solomon. Assessing the Methodology for Calculating Platelet Contribution to Clot Strength (Platelet Component) in Thromboelastometry and Thrombelastography. Anesth Analg 2015;121(4):868-878
- Krombach. Development and Implementation of Checklists for Routine Anesthesia Care: A Proposal for Improving Patient Safety. Anesth Analg 2015;121(4):1097–1103
British Journal of Anaesthesia
- Columb. Programmes, guidelines and protocols – the antithesis of precision medicine? Br J Anaesth 2015;115(4):485-487
- Smith. Cerebral perfusion pressure. Br J Anaesth 2015;115(4):488-490
- Dong. Ketamine: a growing global health-care need. Br J Anaesth 2015;115(4):491-493
- Cook. Time to abandon the ‘vintage’ laryngeal mask airway and adopt second-generation supraglottic airway devices as first choice. Br J Anaesth 2015;115(4):497-499
- Rodney. Not just monitoring; a strategy for managing neuromuscular blockade. Anaesthesia 2015;70:1105–1109
- Palanisamy. Patient safety vs social hierarchy – too close to call?. Anaesthesia 2015;70:1110–1113
- Hildyard. Point-of-care testing: a standard of care?. Anaesthesia 2015;70:1113–1118
- Giannini. “Why can’t I give you my organs after my heart has stopped beating?” An overview of the main clinical, organisational, ethical and legal issues concerning organ donation after circulatory death in Italy. Minerva Anestesiologica 2016;82(3):359-68
- Deflandre. It is time for anesthetists to act as perioperative physicians. Minerva Anestesiologica 2016;82(3):257-8
- Kaufmann. How should pediatric anesthesia respond on the discussion about neurotoxicity in daily practice? Minerva Anestesiologica 2016;82(3):259-61
- Festen. The end of an era of pharmaconutrition and immunonutrition trials for the critically-ill patient? Minerva Anestesiologica 2016;82(3):262-4
- Ball. Predictive scores for postoperative pulmonary complications: time to move towards clinical practice. Minerva Anestesiologica 2016;82(3):265-7
- Vincent. How genomics can improve the management of septic patients. Minerva Anestesiologica 2016;82(3):268-70
- Nanni Costa. Organ donation after circulatory death in Italy? Yes we can! Minerva Anestesiologica 2016;82(3):271-3
- Vargas. Physiologic Effects of High-Flow Nasal Cannula Oxygen in Critical Care Subjects. Respir Care 2015;60(10):1369-1376
- Facchin. Airway Pressure Release Ventilation and High-Frequency Oscillatory Ventilation: Potential Strategies to Treat Severe Hypoxemia and Prevent Ventilator-Induced Lung Injury. Respir Care 2015;60:10 1509-1521
- Guasch. Massive obstetric hemorrhage: Current approach to management. Med Intensiva 2016;40:298-310
- Medina. PALICC definition of ARDS. Don’t remove that brick from the wall and keep it smart and simple. Med Intensiva 2016;40:311-4
- van Zanten. Do we need new prokinetics to reduce enteral feeding intolerance during critical illness? Critical Care 2016;20:294
- Benoit. Focus on adequate antimicrobial treatment and de-escalation in the ICU. Intensive Care Med 2016;epublished September 29th
- Marshall. Time for a breath of fresh air: Rethinking training in airway management. Anaesthesia 2016;epublished September 28th
- Girotra. Post-cardiac arrest mortality is declining in the UK. Critical Care 2016;20:304
- Iba. Bleeding complications of anticoagulant therapy in sepsis-induced disseminated intravascular coagulation. Critical Care 2016;20:307
- Morici. Vasopressors and inotropes in cardiogenic shock: is there room for “adrenaline resuscitation”? Critical Care 2016;20:302
- Ray. Real-life use of vasopressors and inotropes in cardiogenic shock—observation is necessarily ‘theory-laden’. Critical Care 2016;20:293
- Jiang. Adrenaline use is associated with excess organ injury and mortality in cardiogenic shock: facts and fiction. Critical Care 2016;20:292
- Koopmans. Improvement in functional abilities at ICU discharge is feasible without prolongation of the length of stay ICU. Intensive Care Med 2016;epublished September 29th
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
Registration for Das SMACC opens this month. I'll let you know exactly when, but be ready to book immediately as tickets will sell out in minutes.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever.Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week