Welcome to the 250th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's another big issue, whose highlights are the 4th edition of the Brain Trauma Foundation guideline on the management of severe traumatic brain injury, as well as a three-way debate on randomised controlled trials versus personalised medicine, which is very similar to the Great Debate at #CCR16 between Luciano Gattinoni & Jean-Louis Vincent, with comments from the other speakers and delegates. Hopefully, I'll be able to release this soon (slide availability issue at present).
Staying with #CCR17, the programme is now out, featuring a fantastic line-up of trials, speakers, and talks. If your colleagues might be interested in attending, please forward this newsletter or link to the meeting webpage to them.
This week's Topic of the Week is the endothelial glycocalyx, a topic anyone prescribing fluid should be familiar with, starting with a paper on the revised Starling equation and the glycocalyx model of transvascular fluid exchange by @thomaswoodcock in tomorrow's Paper of the Day.
- Abstract: Álvarez. Occupational therapy for delirium management in elderly patients without mechanical ventilation in an intensive care unit: A pilot randomized clinical trial. J Crit Care 2016;37:85-90
- Full Text: Liu. Dexmedetomidine sedation reduces atrial fibrillation after cardiac surgery compared to propofol: a randomized controlled trial. Critical Care 2016;20:298
- Abstract: Grant. Dexmedetomidine Use in Critically Ill Children With Acute Respiratory Failure. Pediatr Crit Care Med 2016;epublished September 20th
- Abstract: Karkouti. Point-of-Care Hemostatic Testing in Cardiac Surgery: A Stepped-Wedge Clustered Randomized Controlled Trial (TACS Trial). Circulation 2016;epublished September 21st
- Abstract: Roberts. Nasal High-Flow Therapy for Primary Respiratory Support in Preterm Infants (HIPSTER Trial). N Engl J Med 2016;375:1142-1151
- Abstract: Roberts. Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials. Am J Respr Crit Care Med 2016;194(6):681-691
- Full Text: Ouweneel. Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis. Intensive Care Med 2016;epublished September 19th
- Abstract: Yamada. Glycemic control, mortality, and hypoglycemia in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials. Intensive Care Med 2016;epublished September 16th
- Abstract: Vardakas. Colistin versus polymyxin B for the treatment of patients with multidrug-resistant Gram-negative infections: a systematic review and meta-analysis. Journal of Antimicrobial Agents 2016;epublished September 16th
- Abstract: Monro-Somerville. The Effect of High-Flow Nasal Cannula Oxygen Therapy on Mortality and Intubation Rate in Acute Respiratory Failure: A Systematic Review and Meta-Analysis. Crit Care Med 2016;epublished September 8th
- Abstract: Millin. Patients without ST elevation after return of spontaneous circulation may benefit from emergent percutaneous intervention: A systematic review and meta-analysis. Resuscitation 201;epublished September 15th
- Abstract: Bouteloup. Outcomes in adult critically Ill cancer patients with and without neutropenia: a systematic review and meta-analysis of the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie. Oncotarget 2016;epublished September 21st
- Abstract: Wong. Antithrombin Concentrate Use in Pediatric Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study. Pediatr Crit Care Med 2016;epublished Septemner 22nd
- Abstract: Petersson. Standard dosing of piperacillin and meropenem fail to achieve adequate plasma concentrations in ICU patients. Acta Anaesthesiol Scand 2016;epublished September 21st
- Abstract: Pfoh. Physical declines occurring after hospital discharge in ARDS survivors: a 5-year longitudinal study. Intensive Care Med 2016;epublished September 16th
- Abstract: Gattinoni. Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med 2016;epublished September 12th
- Abstract: Jabre. Early Identification of Patients With Out-of-Hospital Cardiac Arrest With No Chance of Survival and Consideration for Organ Donation. Ann Intern Med 2016;epublished September 13th
- Abstract: Vignon. Comparison of Echocardiographic Indices Used to Predict Fluid Responsiveness in Ventilated Patients. Am J Respir Crit Care Med 201;epublished September 21st
- Abstract: Churpek. qSOFA, SIRS, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients Outside the ICU. Am J Respir Crit Care Med 2016;epublished September 20th
- Abstract: Carrie. Ultrasonographic diaphragmatic excursion is inaccurate and not better than the MRC score for predicting weaning-failure in mechanically ventilated patients. Anaesth Crit Care Pain Med 2016;epublished September 16th
- Abstract: Lemiale. High-Flow Nasal Cannula Oxygenation in Immunocompromised Patients With Acute Hypoxemic Respiratory Failure: A Groupe de Recherche Respiratoire en Reanimation Onco-Hematologique Study. Crit Care Med 2016;epublished September 20th
- Abstract: Tanaka. Effect of RBC Transfusion on Sublingual Microcirculation in Hemorrhagic Shock Patients: A Pilot Study. Crit Care Med 2016;epublished September 15th
- Perkins. Pre-hospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug administration In Cardiac arrest (PARAMEDIC-2): Trial protocol. Resuscitation 2016;epublished September 17th
- Messika. Effect of a musical intervention on tolerance and efficacy of non-invasive ventilation in the ICU: study protocol for a randomized controlled trial (MUSique pour l’Insuffisance Respiratoire Aigue - Mus-IRA). Trials 2016;17:450
- de Oliveira. The critical care management of spontaneous intracranial hemorrhage: a contemporary review. Crit Care 2016;20(1):272
- Ergle. Percutaneous Ventricular Assist Devices: A Novel Approach in the Management of Patients With Acute Cardiogenic Shock. The Ochsner Journal: Fall 2016;16(3):243-249
- Englert. Mechanical Circulatory Support for the Failing Heart: Continuous-Flow Left Ventricular Assist Devices. The Ochsner Journal: Fall 2016;16(3):263-269
- Ferrari. Remodelling after an Infarct: Crosstalk between Life and Death. Cardiology 2016;135:68-76
- Gaasch. Right Heart Pressure Transients and Pulmonary Venous Pressure. Cardiology 2016;135:77-80
- Hughes. Pulmonary Manifestations of Acute Lung Injury: More Than Just Diffuse Alveolar Damage. Arch Pathol Lab Med 201;epublished September 21st
- Yamamoto. Removal of uremic toxins by renal replacement therapies: a review of current progress and future perspectives. Renal Replacement Therapy 2016;2:43
- Enescu. Hepatorenal Syndrome: Diagnosis and Treatment - newsreel. Rom J Intern Med 2016;54(3):143-150
- Brown. Nonvitamin K antagonist oral anticoagulant activity: challenges in measurement and reversal. Critical Care 2016;20:273
- Kolev. Bleeding related to disturbed fibrinolysis. Br J Haematol 2016;175:12–23
- Warkentin. Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia. Thromb Haemost 2016;116(5)
- Jiménez-Yuste. The evolving role and future relevance of plasma-derived therapies in the management of bleeding disorders. Thromb Haemost 2016;116 Suppl.1:S1-S1
- Wong. Cryoprecipitate transfusion: current perspectives. International Journal of Clinical Transfusion Medicine 2016;4:89-97
- Pacheco. Ebola virus - from neglected threat to global emergency state. Rev Assoc Med Bras 2016;62(5):458-67
- Marston. Antimicrobial Resistance. JAMA 2016;316(11):1193-1204
- Attri. Perioperative death: Its implications and management. Saudi J Anaesth 2016;10:436-9
- Aich. Could Perioperative Opioid Use Increase the Risk of Cancer Progression and Metastases? International Anesthesiology Clinics 2016;54(4):e1–e16
- Piegeler. Do Amide Local Anesthetics Play a Therapeutic Role in the Perioperative Management of Cancer Patients? International Anesthesiology Clinics 2016;54(4):e17–e32
- Kim. The Impact of Postoperative Complications on a Timely Return to Intended Oncologic Therapy (RIOT): the Role of Enhanced Recovery in the Cancer Journey. International Anesthesiology Clinics 2016;54(4):e33–e46
- Royds. An Update on Existing Ongoing Prospective Trials Evaluating the Effect of Anesthetic and Analgesic Techniques During Primary Cancer Surgery on Cancer Recurrence or Metastasis. International Anesthesiology Clinics 2016;54(4):e76–e83
- Wigmore. Outcomes for Critically Ill Cancer Patients in the ICU: Current Trends and Prediction. International Anesthesiology Clinics 2016;54(4):e62–e75
- Carney. Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition. Neurosurgery 2016;epublished September 22nd (Executive Summary)
- Complete Guideline - Guidelines for the Management of Severe Traumatic Brain Injury 4th Edition
- Thiele. American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on perioperative fluid management within an enhanced recovery pathway for colorectal surgery. Perioperative Medicine 2016;5:24
- Yancy. 2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: An Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure. A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. J Am Coll Cardiol 2016;68(13):1476-1488
- Vohraa. CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. Journal of Clinical Epidemiology 2016;76:9-17
- Zarin. Trial Reporting in ClinicalTrials.gov — The Final Rule. N Engl J Med 2016;epublished September 16th
- Improved survival in critically ill patients: are large RCTs more useful than personalized medicine?
- Marini. Dynamic predictors of VILI risk: beyond the driving pressure. Intensive Care Med 2016;epublished September 16th
- Kostakou. Electrical impedance tomography to determine optimal positive end-expiratory pressure in severe chronic obstructive pulmonary disease. Critical Care 2016;20:295
- Villar. Concerns about LUNG-SAFE: response to the letter to the Editor of Critical Care by Bellani et al. Critical Care 2016;20:296
- Gutierrez. Work of breathing, not dysoxia, as the cause of low central venous blood O2 saturation in sepsis. Critical Care 2016;20:291
- Yu. Bronchoalveolar lavage fluid galactomannan as a diagnostic biomarker for IPA: still a long way to go. Critical Care 2016 20:280
- Ligtenberg. Interhospital critical care transports: have a safe trip! Intensive Care Med 2016;epublished September 12th
- Ribeiro. Increased mortality with the use of adrenaline in shock: the evidence is still limited. Critical Care 2016;20:289
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Registration for Das SMACC opens next month. I'll let you know exactly when, but be ready to book immediately as tickets will sell out in minutes.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
Registration is yet to open so do subscribe to its newsletter at www.sg-anzics.com for updates.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week