Welcome to the 242nd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's issue are a cluster randomised controlled trial investigating a multifacted programme for improving sedation and analgesia for mechanically ventilated patients, a report on end-of-life care in the ICU, and review articles on early mobilization, Takotsubo syndrome and mean arterial pressure targets in septic shock. In addition, there is a great commentary on what happens when underperforming big ideas in research become entrenched as well as a thought-provoking editorial on awareness in the dying human brain: implications for organ donation practices. This week's Topic of the Week is the latest on our series of guidelines, this time focusing on renal critical care, starting with a paper on the current use of biomarkers in acute kidney injury in tomorrow's Paper of the Day.
The second Critical Care Reviews Podcast is now out also, featuring Glenn Eastwood from Melbourne, Australia, discussing the TAME Cardiac Arrest Trial. If you want to comment on either a podcast or any paper in this newsletter, I've re-instituted the comments facility to both of these sections (I had to remove this due to a software incompatibility issue). Comments need to be placed on the website, either on the desktop version of the newsletter or the relevant podcast webpage.
I may not have great internet access next week, so if the newsletter is late, you'll know why.
- Abstract: Walsh. Staff education, regular sedation and analgesia quality feedback, and a sedation monitoring technology for improving sedation and analgesia quality for critically ill, mechanically ventilated patients: a cluster randomised trial. Lancet Respir Med 2016;epublished July 26th
- Full Text: Frazzitta. Effectiveness of a Very Early Stepping Verticalization Protocol in Severe Acquired Brain Injured Patients: A Randomized Pilot Study in ICU. PLoS ONE 2016;11(7):e0158030
- Abstract: Wang. Association between chloride-rich versus chloride-restrictive intravenous fluid administration and acute kidney injury in cardiovascular patients in ICU wards. Exp Ther Med 2016;12(2):987-990
- Abstract: Uranga. Duration of Antibiotic Treatment in Community-Acquired PneumoniaA Multicenter Randomized Clinical Trial. JAMA Intern Med 2016;epublished July 25th
- Full Text: Dugernier. Aerosol delivery with two ventilation modes during mechanical ventilation: a randomized study. Ann Intensive Care 2016;6(1):73
- Full Text: Guo. Mechanical ventilation strategies for intensive care unit patients without acute lung injury or acute respiratory distress syndrome: a systematic review and network meta-analysis. Critical Care 2016;20:226
- Full Text: Stevenson. Sepsis: the LightCycler SeptiFast Test MGRADE(R), SepsiTest and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi - a systematic review and economic evaluation. Health Technol Assess 2016;20(46):1-246
- Abstract: Pettilä. Control groups in recent septic shock trials: a systematic review. Intensive Care Med 2016;epublished July 23rd
- Abstract: Martins. Palliative care for terminally ill patients in the intensive care unit: Systematic review and metaanalysis. Palliat Support Care 2016;epublished July 27th
- Full Text: Koster. Milrinone for cardiac dysfunction in critically ill adult patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med 2016;epublished July 22nd
- Abstract: de Meirelles Almeida. Diastolic dysfunction as a predictor of weaning failure: A systematic review and meta-analysis. J Crit Care 2016;34:135-141
- Abstract: Pettilä. Control groups in recent septic shock trials: a systematic review. Intensive Care Med 2016;epublished July 23rd
- Full Text: Zakharchenko. The Effects of High Level Magnesium Dialysis/Substitution Fluid on Magnesium Homeostasis under Regional Citrate Anticoagulation in Critically Ill. PLoS One 2016;11(7):e0158179
- Abstract: Zhu. Assessing Protocol Adherence in a Clinical Trial with Ordered Treatment Regimens: Quantifying the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial Experience. Injury 2016;epublished July 20th
- Abstract: Brown. Predictors of 6-month health utility outcomes in survivors of acute respiratory distress syndrome. Thorax 2016;epublished July 20th
- Abstract: Braune. The feasibility and safety of extracorporeal carbon dioxide removal to avoid intubation in patients with COPD unresponsive to noninvasive ventilation for acute hypercapnic respiratory failure (ECLAIR study): multicentre case–control study. Intensive Care Med 2016;epublished July 25th
- Abstract: Kadri. Estimating Ten-Year Trends in Septic Shock Incidence and Mortality in United States Academic Medical Centers Using Clinical Data. Chest 2016;epublished July 28th
- Abstract: Klouwenberg. Incidence, Predictors and Outcomes of New-onset Atrial Fibrillation in Critically Ill Patients with Sepsis: a Cohort Study. Am J Respir Crit Care Med 2016;epublished July 28th
- Full Text: Coupez. Guidewire exchange vs new site placement for temporary dialysis catheter insertion in ICU patients: is there a greater risk of colonization or dysfunction? Critical Care 2016;20:230
- Abstract: Ranzani. The Challenge of Predicting Pressure Ulcers in Critically Ill Patients: A Multicenter Cohort Study. Annals ATS 2016;epublished 27 July 2016
- Abstract: Martin. ALIAS (Albumin in Acute Ischemic Stroke) Trials: Analysis of the Combined Data From Parts 1 and 2. Stroke 2016;epublished July 26th
- Abstract: Hay. Characteristics and outcome of patients with the ICU Admission diagnosis of status epilepticus in Australia and New Zealand. J Crit Care 2016;34:146–153
- Abstract: Salih. Intracranial pressure and cerebral perfusion pressure in patients developing brain death. J Crit Care 2016;34:1-6
- Abstract: Delgado. Safety of peripheral administration of phenylephrine in a neurologic intensive care unit: A pilot study. J Crit Care 2016;34:107-110
- Taito. Early mobilization of mechanically ventilated patients in the intensive care unit. Journal of Intensive Care 2016;4:50
- Disma. Pediatric anesthesia and neurotoxicity: can findings be translated from animals to humans? Minerva Anestesiologica 2016;82(7):791-6
- Eytan. Bedside functional brain imaging in critically-ill children using high-density EEG source modeling and multi-modal sensory stimulation. Neuroimage Clin 2016;12:198-211
- D'Andrea. Transcranial Doppler ultrasonography: From methodology to major clinical applications. World J Cardiol 2016;8(7):383-400
- Sen. Mechanical circulatory assist devices: a primer for critical care and emergency physicians. Critical Care 2016;20:153
- Mejía-Rentería. Takotsubo syndrome: Advances in the understanding and management of an enigmatic stress cardiomyopathy. World J Cardiol 2016;8(7):413-424
- Ryerson. Anticoagulation Management and Monitoring during Pediatric Extracorporeal Life Support: A Review of Current Issues. Front Pediatr 2016;4:67
- Filosso. When size matters: changing opinion in the management of pleural space—the rise of small-bore pleural catheters. J Thorac Dis 2016;8(7):E503-E510
- Vickers. Ridinilazole: a novel therapy for Clostridium difficile infection. International Journal of Antimicrobial Agent 2016;48(2):137–143
- Bolondi. Predictive factors of short term outcome after liver transplantation: A review. World J Gastroenterol 2016;22(26):5936-5949
- Donnelly. Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy. World J Gastroenterol 2016;22(26):5958-5970
- Shayto. Use of rifaximin in gastrointestinal and liver diseases. World J Gastroenterol 2016;22(29):6638-6651
- Kasarala. Standard liver tests. Clinical Liver Disease 2016;8:13–18
- Volk. Patient-centered liver transplantation. Clinical Liver Disease 2016;8:24–27
- Beloncle. Mean arterial pressure target in patients with septic shock. Minerva Anestesiologica 2016;82(7):777-84
- Leligdowicz. Ebola virus disease and critical illness. Critical Care 2016;20:217
- Hidalgo. Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated intra-abdominal infections. Drug Design, Development and Therapy 2016;10:2379—2386
- Nathwani. Early clinical assessment of response to treatment of skin and soft-tissue infections: how can it help clinicians? Perspectives from Europe. International Journal of Antimicrobial Agent 2016;48(2):127–136
- Nadel. Treatment of Meningococcal Disease. J Adolesc Health 2016;59(2 Suppl):S21-8
- Kumar. Role of magnetic resonance imaging in acute spinal trauma: a pictorial review. BMC Musculoskeletal Disorders 2016;17:310
- Krishnamoorthy. The role of electroencephalography in the diagnosis of serotonin syndrome. JICS 2016;17(3):258-261
- Schuckit. Treatment of Opioid-Use Disorders. N Engl J Med 2016;375:357-368
- Warrillow. how to improve communication quality with patients and relatives in the ICU. Minerva Anestesiologica 2016;82(7):797-803
- Szawarski. Classic cases revisited: Mr David James, futile interventions and conflict in the ICU. JICS 2016;17(3):244-251
- Blanch. Dead space in acute respiratory distress syndrome: more than a feeling! Critical Care 2016;20:214
- Cardinal-Fernández. ARDS: Time to “separate the wheat from the chaff”. J Crit Care 201;34:31-32
- Guerin. Assessment of oxygenation response to prone position ventilation in ARDS by lung ultrasonography. Intensive Care Med 2016;epublished July 22nd
- Rady. Neuroscience and awareness in the dying human brain: Implications for organ donation practices. J Crit Care 201;34:31-33
- Jones. Methadone in the critically ill—An unlikely player in intensive care medicine. J Crit Care 201;34:162
- Kroll. Rare Presentation of Pulmonary Alveolar Proteinosis Causing Acute Respiratory Failure. Canadian Respiratory Journal 2016;2016:4064539
- Mohamed. Hyperventilation-related hyperlactataemia in a case of paroxysmal vocal cord dysfunction. JICS 2016;17(3):22-265
- Mathew. A Woman in Her 70s With Profound Hypoxemia. Chest 2016;150(1):e13-e17
- Zider. An 80-Year-Old Woman With Progressive Shortness of Breath and a Mediastinal Mass. Chest 2016;150(1):e19-e22
- Dillien. New-Onset Refractory Status Epilepticus: More Investigations, More Questions. Case Rep Neurol 2016;8(2):127-33
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
The 1st World Sepsis Congress will take place completely online on September 8th and 9th, 2016, as a prelude and introduction to the fifth World Sepsis Day on September 13th, 2016. Participation is open to everyone with an internet connection and free of charge. In 13 distinctive sessions, over 70 speakers from over 20 countries will give 10-minute keynotes and presentations on the number one preventable cause of death worldwide: sepsis. After each talk, the speakers will answer live questions from the audience.
Highlights include the Opening Session, titled "Sepsis - A Global Health Threat", with German Minister Helge Braun, Marie-Paule Kieny, Assistant Director-General of the WHO, Achim Steiner, former Under-Secretary General UN and Director of UNEP, and Joe Kiani, Founder & CEO of the Patient Safety Movement Foundation. To read the full invitation letter from the program chairs, Simon Finfer and Konrad Reinhart, please click here.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions. Registration is yet to open so do subscribe to its newsletter at www.sg-anzics.com for updates.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week