Welcome to the 241st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a great issue this week, with some very interesting randomised controlled trials, including studies investigating the effects of cyclosporine in nonshockable out-of-hospital cardiac arrest, sodium selenite & procalcitonin-guided therapy in sepsis and inhaled prophylactic heparin for the prevention and management of pneumonia in ventilated ICU patients.
There are numerous great review articles including papers on vitamin D in critically ill patients, cytokine-adsorbing hemofilter and unpeeling the evidence for the Banana Bag. There are also commentaries on the sepsis-3 definition and beyond the Ebola battle — winning the war against future epidemics plus editorials on glutamine in critically ill patients and recruitment maneuvers for acute respiratory distress syndrome. If you only have time for one paper this week, try this one: "echocardiographic assessment of myocardial ischemia".
This week's Topic of the Week is a selection of hepatic guidelines, starting with a paper on the revised American Association for the Study of Liver Diseases position paper on acute liver failure in tomorrow's Paper of the Day.
An excellent free sepsis webinar is planned for early September, featuring a stellar list of global speakers. See below for more details.
- Abstract: Argaud. Effect of Cyclosporine in Nonshockable Out-of-Hospital Cardiac Arrest: The CYRUS Randomized Clinical Trial (CYRUS Study). JAMA Cardiol 2016;epublished July 13th
- Abstract: Bloos. Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock. A Rando. mized Clinical Trial. JAMA Intern Med 2016;epublished July 18th
- Full Text: IPHIVAP investigators of the ANZICS CTG. Is inhaled prophylactic heparin useful for prevention and management of pneumonia in ventilated ICU patients? J Crit Care 2016;epublished July 15th
- Full Text: Hou. Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis. Shock 2016;46(2):132–138
- Abstract: Hervé. Effects of Increasing Hydrocortisone to 300 MG per Day in the Treatment of Septic Shock: A Pilot Study. Shock 2016;epublished July 11th
- Abstract: Ferrie. Protein Requirements in the Critically Ill. A Randomized Controlled Trial Using Parenteral Nutrition. JPEN J Parenter Enteral Nutr 2016 vol. 40 no. 6 795-805
- Abstract: Laina. Amiodarone and cardiac arrest: Systematic review and meta-analysis. Int J Cardiol 2016;221:780-788
- Full Text: Lal. Prolonged versus Intermittent Infusion of β-Lactams for the Treatment of Nosocomial Pneumonia: A Meta-Analysis. Infect Chemother 2016;48(2):81-90
- Full Text: Tao. Effects of omega-3 fatty acid nutrition on mortality in septic patients: a meta-analysis of randomized controlled trials. BMC Anesthesiology 2016;16:39
- Abstract: Liu. Is Urgent Decompression Superior to Delayed Surgery for Traumatic Spinal Cord Injury? A Meta-Analysis. World Neurosurg 2016;87:124-31
- Abstract: Parent. Use of Metabolomics to Trend Recovery and Therapy After Injury in Critically Ill Trauma Patients. JAMA Surg 2016;151(7):e160853
- Full Text: Rotman. Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS. BMC Anesthesiology 2016;16:40
- Full Text: Gräsner. EuReCa ONE—27 Nations, ONE Europe, ONE Registry. A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe. Resuscitation 2016;105:188-195
- Abstract: Rajan. Prolonged cardiopulmonary resuscitation and outcomes after out-of-hospital cardiac arrest. Resuscitation 2016;105:45-51
- Full Text: Sahni. Surgeon specialization and operative mortality in United States: retrospective analysis. BMJ 2016;354:i3571
- Full Text: Gabler. No improvement in the reporting of clinical trial subgroup effects in high-impact general medical journals. Trials 2016;17:320
- Full Text: Du. Efficacy and Safety of Esmolol in Treatment of Patients with Septic Shock. Chin Med J 2016;129:1658-65
- Steinmetz. Pilot Randomized trial of Fibrinogen in Trauma Haemorrhage (PRooF-iTH): study protocol for a randomized controlled trial. Trials 2016;17:327
- Hellyer. Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2): study protocol for a randomised controlled trial. Trials 2016;17:318
- Chia. Overview of implantable cardioverter defibrillator and cardiac resynchronisation therapy in heart failure management. Singapore Med J 2016;57(7);354-359
- Barros. Acute pulmonary edema and elevated troponin: what is their significance? Brazilian Journal of Medicine and Human Health 2016;4(2)
- Bazylevska. D-dimer measurements in acute aortic dissection. SWRCCC 2016;4(15):38-46
- Sachidananda. A review of hemodynamic response to the use of different types of laryngoscopes. Anaesth Pain & Intensive Care 2016;20(2):201-208
- Salvagno. Prognostic biomarkers in acute coronary syndrome. Ann Transl Med 2016;4(13):258
- Leischik. Echocardiographic assessment of myocardial ischemia. Ann Transl Med 2016;4(13):259
- Bas. Acute kidney injury associated with concomitant use of vancomycin with piperacillin-tazobactam: a focused review and meta-analysis. SWRCCC 2016;4(15);32-37
- Rambaran. Vancomycin induced acute kidney injury: a review of the literature. SWRCCC 2016;4(15);47-50
- Matysiak-Luśnia. Vitamin D in critically ill patients. Anaesthesiol Intensive Ther 2016;48(3):201-207
- Levitt. Human serum albumin homeostasis: a new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements. International Journal of General Medicine 2016:9:229—255
- Ruthirago. Acute porphyrias and porphyric neuropathy. SWRCCC 2016;4(15):21-31
- Warkentin. How I treat patients with a history of heparin-induced thrombocytopenia. Blood 2016;128:348-359
- Nomura. Advances in Diagnosis and Treatments for Immune Thrombocytopenia. Clinical Medicine Insights: Blood Disorders 2016;9:15-22
- Hattori. Cytokine-adsorbing hemofilter: old but new modality for septic acute kidney injury. Renal Replacement Therapy 2016;2:41
- Kempke. Antimicrobial Doses in Continuous Renal Replacement Therapy: A Comparison of Dosing Strategies. Crit Care Res Pract 2016;2016:3235765
- Guzman Prieto. Global Emergence and Dissemination of Enterococci as Nosocomial Pathogens: Attack of the Clones? Front. Microbiol 2016;7:788
- Izumikawa. Clinical Features of Severe or Fatal Mycoplasma pneumoniae Pneumonia. Front. Microbiol 2016;7:800
- Sartelli. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World J Emerg Surg 2016;11:33
- Kulshrestha. Inter-hospital and intra-hospital patient transfer: Recent concepts. Indian J Anaesth 2016;60:451-7
- Flannery. Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU. Crit Care Med 2016;44(8):1545–1552
- Soma-Pillay. Physiological changes in pregnancy. Cardiovasc J Afr 2016;27(2): 89–94
- Whiting. Amniotic fluid emboli update. SWRCCC 2016;4(15):51-55
- Singh. Use of computer-assisted drug therapy outside the operating room. Curr Opin Anaesth 2016;29(4):56-511
- Choi. A new therapeutic option for postoperative pain management with oxycodone HCI injection. Korean J Anesthesiol 2016;69(3):211-218
- Althouse. Propensity-score matching: a clinician’s guide. SWRCCC 2016;4(15);82-85
- Taraban. Institutional review board review of clinical research. SWRCCC 2016;4(15);89-93
- Lee. Avoiding negative reviewer comments: common statistical errors in anesthesia journals. Korean J Anesthesiol 2016;69(3):219-226
- Koo. Guidelines help us to keep calm when facing a difficult airway. Korean J Anesthesiol. 2016;69(3):209-210
- Nugent. New definitions for sepsis and septic shock. SWRCCC 2016;4(15)7-8
- Cavallazzi. Tuberculosis is always a possibility (even in the intensive care unit). Rev Bras Ter Intensiva 2016;28(2):97-99
- Martins. Glutamine in critically ill patients: is it a fundamental nutritional supplement? Rev Bras Ter Intensiva 2016;28(2):100-103
- Silva. Recruitment maneuvers for acute respiratory distress syndrome: the panorama in 2016. Rev Bras Ter Intensiva 2016;28(2):104-106
- Anderson-Shaw. Surviving Severe Sepsis: Is That Enough? Crit Care Med 2016;44(8):1603-1604
- Aslakson. Beyond “Rationing” and “Death Panels”: The Potential “Escape Fire” of Palliative Care. Crit Care Med 2016;44(8):1605–1606
- Mentzelopoulos. Possible significance of hemodynamic and immunomodulatory effects of early stress-dose steroids in cardiac arrest. Critical Care 2016;20:211
- Procalcitonin to guide antibiotic stewardship in intensive care. Lancet Infect Dis 2016;16(8):887-889 De Santis | Kip | Dorizzi | Reply - de Jong
- Tunali. Fever treatment with a catheter-based heat exchange system in the neurointensive care unit. Anaesthesiology Intensive Therapy 2016;48(3):208–210
- Kosinski. The longest persisting ventricular fibrillation with an excellent outcome – 6 h 45 min cardiac arrest. Resuscitation 2016;105:e21-22
- Richards. Co-trimoxazole-induced hypoglycaemia in an immunosuppressed intensive care patient. JICS 2016;epublished July 15th
- Son. Experience of hemostasis in tracheal bleeding very close to the carina by the bronchial blocker: a case report. Korean J Anesthesiol 2016;69(3):270-274
- Mun. Lethal coronary air embolism caused by the removal of a double-lumen hemodialysis catheter: a case report. Korean J Anesthesiol 2016;69(3):296-300
- Kulkarni. A novel method of airway management in a case of penetrating neck injury. Indian J Anaesth 2016;60:509-11
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
The 1st World Sepsis Congress will take place completely online on September 8th and 9th, 2016, as a prelude and introduction to the fifth World Sepsis Day on September 13th, 2016. Participation is open to everyone with an internet connection and free of charge. In 13 distinctive sessions, over 70 speakers from over 20 countries will give 10-minute keynotes and presentations on the number one preventable cause of death worldwide: sepsis. After each talk, the speakers will answer live questions from the audience.
Highlights include the Opening Session, titled "Sepsis - A Global Health Threat", with German Minister Helge Braun, Marie-Paule Kieny, Assistant Director-General of the WHO, Achim Steiner, former Under-Secretary General UN and Director of UNEP, and Joe Kiani, Founder & CEO of the Patient Safety Movement Foundation. To read the full invitation letter from the program chairs, Simon Finfer and Konrad Reinhart, please click here.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week