Welcome to the 239th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's been a while coming, but finally the Critical Care Reviews Podcast has started, with the first show featuring Paul Young discussing his ICU-ROX trial. The podcast aims to discuss major critical care trials either in progress or soon to start.
The highlights from this week's literature are randomised controlled trials investigating palliative care led-meetings in the ICU, protein C zymogen in severe sepsis, and video laryngoscopy for endotracheal intubation of critically ill adults. There are great editorials on beta-blockade in sepsis and nighttime physician staffing, as well as reviews on myocardial infarction in the ICU and prehospital blood product resuscitation for trauma.
As this newsletter concentrates on the literature, I don't normally mention blogs and other social media resources (which the Life in the Fastlane Review does expertly every week); however, two deserve mention today. Firstly, my friend and St Emlyns' blogger Simon Carley has an excellent post on the EMJ Blog on the recent SMACC panel discussion on the future of publishing, which Simon and I contributed to. Secondly, the Intensive Care Society has a beautiful new website, including all the talks from last year's State-of-the-Art Meeting, which are freely available.
Keeping with a recent focus on guidelines, this week's Topic of the Week looks at seven respiratory guidelines, starting with a paper on the 2014 ESC guideline on the diagnosis and management of acute pulmonary embolism in tomorrow's Paper of the Day.
- Abstract: Carson. Effect of Palliative Care–Led Meetings for Families of Patients With Chronic Critical Illness. A Randomized Clinical Trial. JAMA 2016;316(1):51-62
- Full Text: Conti. Effects of dexmedetomidine and propofol on patient-ventilator interaction in difficult-to-wean, mechanically ventilated patients: a prospective, open-label, randomised, multicentre study. Critical Care 2016;20:206
- Abstract: Pappalardo. Protein C zymogen in severe sepsis: a double-blinded, placebo-controlled, randomized study. Intensive Care Med 2016;epublished June 25th
- Abstract: Janz. Randomized Trial of Video Laryngoscopy for Endotracheal Intubation of Critically Ill Adults. Crit Care Med 2016;epublished June 28th
- Abstract: Carney. Postdischarge Care of Pediatric Traumatic Brain Injury in Argentina: A Multicenter Randomized Controlled Trial. Pediatric Critical Care Med 2016;17(7):658–666
- Abstract: Gao. Impact of statins on ALI/ARDS: A meta-analysis. Pulm Pharmacol Ther 2016;epublished June 29th
- Abstract: Gao. The effect of reintubation on ventilator-associated pneumonia and mortality among mechanically ventilated patients with intubation: A systematic review and meta-analysis. Heart Lung 2016;454):363-371
- Full Text: Nolan. Increasing survival after admission to UK critical care units following cardiopulmonary resuscitation. Critical Care 2016;20:219
- Full Text: Aldridge. Weekend specialist intensity and admission mortality in acute hospital trusts in England: a cross-sectional study. Lancet 2016;388(10040):178–186
- Abstract: Stefan. Outcomes of Noninvasive and Invasive Ventilation in Patients Hospitalized with Asthma Exacerbation. Ann Am Thor Soc 2016;13(7):1096-1104
- Full Text: Abdalla. Lung ultrasound versus chest radiography for the diagnosis of pneumothorax in critically ill patients: A prospective, single-blind study. Saudi J Anaesth 2016;10(3):265-9
- Abstract: Sjoding. Acute Respiratory Distress Syndrome Measurement Error. Potential Effect on Clinical Study Results. Ann Thor Soc 2016;13(7):1123-1128
- Abstract: Neyra. Cumulative Fluid Balance and Mortality in Septic Patients With or Without Acute Kidney Injury and Chronic Kidney Disease. Crit Care Med 2016;epublished June 27th
- Abstract: Kar. Liberal Glycemic Control in Critically Ill Patients With Type 2 Diabetes: An Exploratory Study. Crit Care Med 2016;epublished June 16th
- Abstract: Sterz. Admission of out-of-hospital cardiac arrest victims to a high volume cardiac arrest center is linked to improved outcome. Resuscitation 2016;epublished June 28th
- Full Text: Tarvasmäki. Current real-life use of vasopressors and inotropes in cardiogenic shock - adrenaline use is associated with excess organ injury and mortality. Critical Care 2016;20:208
- Julayanont. Bacterial meningitis and neurological complications in adults. SWRCCC 2016;4(14);5-16
- AlSibai. Management of Acute Hypertensive Response in Patients With Ischemic Stroke. Neurohospitalist 2016;6(3):122–129
- Carroll. Myocardial infarction in intensive care units: A systematic review of diagnosis and treatment. JICS 2016;epublished July 1st
- Sotello. Clinical studies with high flow nasal cannula oxygen delivery in 2015. SWRCCC 2016;4(14);17-22
- Tsim. ATOTW #333 - Breathing Systems in Anaesthesia. World Federation of Socities of Anesthesiologists 2016;epublished July 5th
- Shein. Contemporary treatment of children with critical and near-fatal asthma. Rev Bras Ter Intensiva 2016;epublished June 10th
- Donnelly. Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy. World J Gastroenterol 2016;22(26):5958-5970
- Doyle. Acute kidney injury: short-term and long-term effects. Critical Care 2016;20:188
- O’Neal. Acute kidney injury following cardiac surgery: current understanding and future directions. Critical Care 2016;20:187
- Selby. Care Bundles for Acute Kidney Injury: Do They Work. Nephron 2016;epublished July 5th
- Nobre. Prognostic value of procalcitonin in hospitalized patients with lower respiratory tract infections. Rev Bras Ter Intensiva 2016;epublished June 10th
- Zlamy. Rediscovering Pertussis. Front Pediatr 2016;4:52
- Coyle. Zika virus: What nurses need to know. Nursing Critical Care 2016;11(4):30–34
- Tonglet. Massive bleeding following severe blunt trauma: the first minutes that can change everything. Acta Chir Belg 2016;116(1):11-5
- Smith. Prehospital Blood Product Resuscitation for Trauma: A Systematic Review. Shock 2016;46(1):3–16
- Doarn. Telementoring and Teleproctoring in Trauma and Emergency Care. Curr Trauma Rep 2016;epublished July 8th
- Bess. Battlefield Teleradiology. Curr Trauma Rep 2016;epublished July 7th
- Bauman. Advancing Trauma and Emergency Education Through Virtual Presence. Curr Trauma Rep 2016;epublished June 28th
- Nielsen. Damage Control Resuscitation and Surgery in a Forward Combat Setting. Curr Trauma Rep 2016;epublished June 6th
- Prabhakaran. Telemedicine for Trauma and Emergency Management: an Overview. Curr Trauma Rep 2016;epublished May 27th
- Reuter. Beta-blockers in septic shock to optimize hemodynamics? Yes. Intensive Care Med 2016;epublished June 27th
- McLean. Beta-blockers in septic shock to optimize hemodynamics? No. Intensive Care Med 2016;epublished June 27th
- De Backer. Beta-blockers in septic shock to optimize hemodynamics? We are not sure. Intensive Care Med 2016;epublished June 27th
- Wallace. Nighttime physician staffing improves patient outcomes: yes. Intensive Care Med 2016;epublished June 27th
- Kerlin. Nighttime physician staffing improves patient outcomes: no. Intensive Care Med 2016;epublished June 27th
- Guidet. Nighttime physician staffing improves patient outcomes: we are not sure. Intensive Care Med 2016;epublished June 27th
- Bernhard. Don’t forget to ventilate during cardiopulmonary resuscitation with mechanical chest compression devices. European Journal of Anaesthesiology 2016;33(8):553-556
- McLaughlin. Dexmedetomidine and delirium in the ICU. Ann Transl Med 2016;4(11):224
- Machowicz. Your critical care patient may have HLH (hemophagocytic lymphohistiocytosis). Crit Care 2016;20(1):215
- Michaels. Jehovah’s Witnesses as Patients. SWRCCC 2016;4(14):23-25
- Ronco. Acute kidney injury: from clinical to molecular diagnosis. Critical Care 2016;20:201
- Russell. Genomics and pharmacogenomics of sepsis: so close and yet so far. Critical Care 2016;20:185
- Monneret. Sepsis in PD-1 light. Critical Care 2016 20:186
- Honore. Propofol infusion syndrome: early blood purification to the rescue? Critical Care 2016;20:197
- Omi. An additional method for the prevention of hypothermia in severely injured trauma patients. Critical Care 2016;20:198
- Glossop. Using noninvasive ventilation to prevent extubation failure: it is good news, but do we really know what “high risk” means? Critical Care 2016;20:213
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
Registration is yet to open so do subscribe to its newsletter at www.sg-anzics.com for updates.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week