Welcome to the 238th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a great newsletter this week, with four big randomised controlled trials, a guideline on Shared Decision Making in ICUs, the best recently made open access articles from the major journals and loads of great review articles. If you only have time for one paper this week, try this one on early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE.
This week's Topic of the Week is the second in a series of guidelines, focusing on circulatory guidelines and starts with the Executive Summary of the 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care in tomorrow's Paper of the Day.
- Abstract: Sierink. Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial. Lancet 2016;epublished June 28th
- Abstract: Morris. Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure. A Randomized Clinical Trial. JAMA 2016;315(24):2694-2702
- Abstract: Cariou. Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial. J Am Coll Cardiol 2016;68(1):40
- Abstract: Schmidt. Effect of a Primary Care Management Intervention on Mental Health–Related Quality of Life Among Survivors of SepsisA Randomized Clinical Trial. JAMA 2016;315(24):2703-2711
- Abstract: Ferrante. Endovascular treatment vs. intravenous thrombolysis alone for ischaemic stroke: a meta-analysis of randomised controlled trials. EuroIntervention 2016;12(2):e271-e281
- Full Text: Horita. Beta-lactam plus macrolides or beta-lactam alone for community-acquired pneumonia: A systematic review and meta-analysis. Respirology 2016;epublished June 23rd
- Full Text: Blot. The value of polyurethane-cuffed endotracheal tubes to reduce microaspiration and intubation-related pneumonia: a systematic review of laboratory and clinical studies. Critical Care 2016;20:203
- Abstract: Deppe. Point-of-care thromboelastography/thromboelastometry-based coagulation management in cardiac surgery: a meta-analysis of 8332 patients. J Surg Res 2016;203(2):424-33
- Abstract: Konstantinos. Clostridium difficile infection following systemic antibiotic administration in randomised controlled trials: a systematic review and meta-analysis. 2016;48(1):1–10
- Abstract: Ali-Hassan-Sayegh. Impact of antioxidant supplementations on cardio-renal protection in cardiac surgery: An updated and comprehensive meta-analysis and systematic review. Cardiovasc Ther 2016;epublished June 27th
- Abstract: Gupta. Impact of 24/7 In-Hospital Intensivist Coverage on Outcomes in Pediatric Intensive Care: A Multi-Center Study. Am J Respir Crit Care Med 2016;epublished July 1st
- Abstract: Tamura. Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome – First-in-Human Pilot Study. Circulation Journal 2016;epublished June 22nd
- Abstract: Vet. Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children. Am J Respir Crit Care Med 2016;194(1):58-66
- Abstract: Ho. A comparison of prognostic significance of strong ion gap (SIG) with other acid-base markers in the critically ill: a cohort study. J Intensive Care 2016;4:43
- Gebistorf. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults. Cochrane Database of Systematic Reviews 2016, Issue 6. Art. No.: CD002787
- Subramaniam. Prophylactic nasal continuous positive airway pressure for preventing morbidity and mortality in very preterm infants. Cochrane Database of Systematic Reviews 2016, Issue 6. Art. No.: CD001243
- Langer. “Awake” extracorporeal membrane oxygenation (ECMO): pathophysiology, technical considerations, and clinical pioneering. Critical Care 2016;20:150
- Søreide. Do cardiac arrest centres save more lives? Trends in Anaesthesia & Critical Care 201;7-8:21-25
- Sajgalik. Current Status of Left Ventricular Assist Device Therapy. Mayo Clin Proc 2016;91(7):927-940
- Mahboub. Potential approaches to improve the outcomes of donation after cardiac death liver grafts. World J Transplant 2016;6(2):314-320
- Kontogiannis. Continuous internal counterpulsation as a bridge to recovery in acute and chronic heart failure. World J Transplant 2016;6(1):115-124
- Krejci. Inflammatory Cardiomyopathy: A Current View on the Pathophysiology, Diagnosis, and Treatment. BioMed Research International 2016;2016:4087632
- Rawal. Acute respiratory distress syndrome: An update and review. Journal of Translational Internal Medicine 2016;2224-4018
- Cousins. Acute oxygen therapy: a review of prescribing and delivery practices. Int J Chron Obstruct Pulmon Dis 2016;11:1067-75
- Taniguchi. Acute and subacute idiopathic interstitial pneumonias. Respirology 2016;21:810–820
- Khan. The significance of clinical scores and biological markers in disease severity, mortality prediction, and justifying hospital admissions in patients with community-acquired pneumonia. Community Acquir Infect 2016;3:36-42
- Dhar. Noninvasive ventilation in hypoxemic respiratory failure. J Assoc Chest Physicians 2016;4:50-5
- Intagliata. Anticoagulation for portal vein thrombosis in cirrhosis. Clinical Liver Disease 2016;7:126–131
- Sanchez. Interpretation of abnormal liver chemistries in the hospitalized patient. Clinical Liver Disease 2016;7:132–134
- Majumdar. The holy grail of a biomarker for “liver function”. Clinical Liver Disease 2016;7:135–138
- Saberi. Current Management of Alcoholic Hepatitis and Future Therapies. J Clin Transl Hepatol 2016;4(2):113–122
- Yoon. Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update. J Clin Transl Hepatol 2016;4(2):131–142
- Mavilia. The Evolving Nature of Hepatic Abscess: A Review. J Clin Transl Hepatol. 2016;4(2):158–168
- Gavito-Higuera. Fungal Infections of the Central Nervous System: A Pictorial Review. J Clin Imaging Sci 2016;6:24
- Cleland. Massive haemorrhage in liver transplantation: Consequences, prediction and management. World J Transplant 2016;6(2):291-305
- Wieland. Clinical examination: Skin. Clinical Liver Disease 2016;7:119–125
- Reuben. Examination of the abdomen. Clinical Liver Disease 2016;7:143–150
- Ganapathy. Neurological examination. Clinical Liver Disease 2016;7:151–153
- Tooley. Clinical examination: Eyes. Clinical Liver Disease 2016;7:154–157
- Peacock. Direct-Acting Oral Anticoagulants: Practical Considerations for Emergency Medicine Physicians. Emergency Medicine International 2016;2016:1781684
- Nguyen. Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Critical Care 2016;20:160
- Wacker. The challenge of learning from perioperative patient harm. Trends in Anaesthesia & Critical Care 201;7-8:5-10
- Apte. Reporting of adverse events for marketed drugs: Need for strengthening safety database. Perspect Clin Res 2016;7:111-4
- Gill. Emerging role of bioinformatics tools and software in evolution of clinical research. Perspect Clin Res 2016;7:115-22
- Ranganathan. Common pitfalls in statistical analysis: Intention-to-treat versus per-protocol analysis. Perspect Clin Res 2016;7:144-6
American Journal of Respiratory Medicine
- Schortgen. Update in Sepsis and Acute Kidney Injury 2014. Am J Respir Crit Care Med 2015;191(12):1226-1231
- Goligher. Update in Mechanical Ventilation, Sedation, and Outcomes 2014. Am J Respir Crit Care Med 2015;191(12):1367-1373
- Johnston. Primary Blast Lung Injury. Am J Respir Crit Care Med 2015;191(12):1462-1463
- Spoletini. Heated Humidified High-Flow Nasal Oxygen in Adults. High-Flow Nasal Oxygen: Mechanisms of Action and Clinical Implications. Chest 2015;148(1):253-261
- Mehta. Common Congenital Anomalies of the Central Airways in Adults. Chest. 2015;148(1):274-287
- Shiloh. A Man in His 60s With Cirrhosis, Encephalopathy, and Shock. A Man in His 60s With Cirrhosis and Shock. Chest. 2015;148(1):e5-e7
- Jain. Management of the Traumatized Airway. Anesthesiology 2016;124:199-206
- Farhan. Acquired Muscle Weakness in the Surgical Intensive Care Unit: Nosology, Epidemiology, Diagnosis, and Prevention. Anesthesiology 2016;124:207-234
- Adams. Uncovering the History of Operating Room Attire through Photographs. Anesthesiology 2016;124:19-24
- Hoy. Living with Lymphangioleiomyomatosis: An Anesthesiologist’s Experience. Anesthesiology 2016;124:235-238
Anesthesia & Analgesia
British Journal of Anaesthesia
- Muñoz. Editor's choice: ‘Fit to fly’: overcoming barriers to preoperative haemoglobin optimization in surgical patients. Br J Anaesth 2015;115(1):15-24
- Davies. Transport of the trauma patient. Br J Anaesth 2015;115(1):33-37
- Ghooi. How informed are our subjects?. Perspect Clin Res 2016;7:109-10
- Gargiulo. Bivalirudin Versus Unfractionated Heparin for Acute Coronary Syndromes: Do We Have a Winner? Rev Esp Cardiol. 2016;epublished June 26th
- Schroeder. Time for a Model List of Essential Diagnostics. N Engl J Med 2016;374:2511-2514
- Dharmalingam. Glycemic control in Intensive Care Unit. Indian J Endocrinol Metab. 2016;20(4):415-7
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
Registration is yet to open so do subscribe to its newsletter at www.sg-anzics.com for updates.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week