Welcome to the 232nd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. It's a massive newsletter this week, with RCTs from the American Thoracic Society Meeting in San Francisco, as well as several other big critical care trials. There are also a host of great review articles, including papers on ultrasound of extravascular lung water, gunshot wounds: A review of ballistics, bullets, weapons, and myths, and mechanical cardiopulmonary resuscitation in and on the way to the cardiac catheterization laboratory.
If you only have time for one review article this week, try this paper on advances in antibiotic therapy in the critically ill. This week's Topic of the Week is the excellent annual Update in Anaesthesia from the World Federation of Societies of Anaesthesiologists, starting with a paper on perioperative acute kidney injury in tomorrow's Paper of the Day.
If you haven't yet completed our Effect Size Survey, please register for the newsletter and follow the link in it.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
American Thoracic Society Meeting
- Full Text: Gaudry. Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit (AKIKI Study). N Engl J Med 2016;epublished May 15th
- Full Text: Kor. Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency DepartmentThe LIPS-A Randomized Clinical Trial (LIPS-A Trial). JAMA 2016;epublished May 15th
- Full Text: Patel. Effect of Noninvasive Ventilation Delivered by Helmet vs Face Mask on the Rate of Endotracheal Intubation in Patients With Acute Respiratory Distress SyndromeA Randomized Clinical Trial. JAMA 2016;epublished May 15th
- Full Text: Zarbock. Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury. The ELAIN Randomized Clinical Trial. JAMA 2016;epublished May 22nd
- Full Text: Mazuski. Efficacy and Safety of Ceftazidime-Avibactam Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-abdominal Infection: Results From a Randomized, Controlled, Double-Blind, Phase 3 Program. Clin Infect Dis 2016;62:1380-1389
- Abstract: Baharoglu. Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial (PATCH Trial). Lancet 2016;epublished May 10th
- Abstract: Gillinov. Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery. N Engl J Med 2016;374:1911-1921
- Full Text: Anderson. Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke (ENCHANTED Trial). N Engl J Med 2016;epublished May 10th
- Full Text: Johnston. Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack. (SOCRATES Trial). N Engl J Med 2016;epublished May 10th
- Full Text: White. Prevalence of and Factors Related to Discordance About Prognosis Between Physicians and Surrogate Decision Makers of Critically Ill Patients. JAMA 2016;315(19):2086-2094
- Abstract: Natalucci. Effect of Early Prophylactic High-Dose Recombinant Human Erythropoietin in Very Preterm Infants on Neurodevelopmental Outcome at 2 Years. A Randomized Clinical Trial. (Swiss EPO Neuroprotection Trial). JAMA 2016;315(19):2079-2085
- Abstract: Ibrahim. Association of Hospital Critical Access Status With Surgical Outcomes and Expenditures Among Medicare Beneficiaries. JAMA 2016;315(19):2095-2103
- Abstract: Cohen. Glucocorticoid Sensitivity Is Highly Variable in Critically Ill Patients With Septic Shock and Is Associated With Disease Severity. Critical Care Med 2016;44(6):1034-1041
- Full Text: Fan. Efficacy and safety of low-molecular-weight heparin in patients with sepsis: a meta-analysis of randomized controlled trials. Scientific Reports 2016;6:25984
- Full Text: Wang. Effect of Antiplatelet Therapy on Acute Respiratory Distress Syndrome and Mortality in Critically Ill Patients: A Meta-Analysis. PLoS One. 2016 May 16;11(5):e0154754
- Full Text: Polleselloa. Levosimendan meta-analyses: Is there a pattern in the effect on mortality? International Journal of Cardiology 2016;209:77-83
- Full Text: Verdoiaa. Bivalirudin Versus Unfractionated Heparin in Acute Coronary Syndromes: An Updated Meta-analysis of Randomized Trials. Rev Esp Cardiol 2016
- Abstract: Silbert. Determinants of Urinary Output Response to IV Furosemide in Acute Kidney Injury: A Pharmacokinetic/Pharmacodynamic Study. Crit Care Med 2016;epublished May 13th
- Abstract: Norman. Employment Outcomes After Critical Illness: An Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychological Dysfunction in ICU Survivors Cohort. Critical Care Med 2016;epublished May 11th
- Full Text: Prescott. Late mortality after sepsis: propensity matched cohort study. BMJ 2016;353:i2375
- Abstract: Tacke. Iron Parameters Determine the Prognosis of Critically Ill Patients. Critical Care Med 2016;44(6):1049-1058
- Free Text: Blankman. Detection of optimal PEEP for equal distribution of tidal volume by volumetric capnography and electrical impedance tomography during decreasing levels of PEEP in post cardiac-surgery patients. Br J Anaesth 2016;116(6):862-9
- Full Text: van Zellem. Cardiac arrest in infants, children, and adolescents: long-term emotional and behavioral functioning. European Journal of Pediatrics 2016;epublished May 14th
- Full Text: Aldridge. Weekend specialist intensity and admission mortality in acute hospital trusts in England: a cross-sectional study. Lancet 2016;epublished May 10th
- Abstract: Bray. Weekly variation in health-care quality by day and time of admission: a nationwide, registry-based, prospective cohort study of acute stroke care. Lancet 2016;epublished May 10th
- Vedel. Perfusion Pressure Cerebral Infarct (PPCI) trial - the importance of mean arterial pressure during cardiopulmonary bypass to prevent cerebral complications after cardiac surgery: study protocol for a randomised controlled trial. Trials 2016;17:247
- Shakur. The effect of tranexamic acid on the risk of death and hysterectomy in women with post-partum haemorrhage: statistical analysis plan for the WOMAN trial. Trials 2016;17:249
- Kanapathy. Epidermal grafting versus split-thickness skin grafting for wound healing (EPIGRAAFT): study protocol for a randomised controlled trial. Trials 2016;17:245
- Gordillo-Escobar. Usefulness of biomarkers in the prognosis of severe head injuries. Medicina Intensiva 2016;40(2):105-112
- Li. Definition, evaluation, and management of brain relaxation during craniotomy. Br J Anaesth 2016;116:759-769
- William. Mechanical Cardiopulmonary Resuscitation In and On the Way to the Cardiac Catheterization Laboratory. Circ J 2016;epublished May 13th
- Lieve. Catecholaminergic Polymorphic Ventricular Tachycardia. Circ J 2016;epublished May 13th
- Nieminena. The role of levosimendan in acute heart failure complicating acute coronary syndrome: A review and expert consensus opinion. International Journal of Cardiology 2016;epublished May 14th
- Zhong. Extracorporeal Membrane Oxygenation as a Bridge for Heart Failure and Cardiogenic Shock. BioMed Research International 2016;2016:7263187
- Montenij. Methodology of method comparison studies evaluating the validity of cardiac output monitors: a stepwise approach and checklist. Br J Anaesth 2016;116:750-758
- Cardinal-Fernándeza. Acute Respiratory Distress: From syndrome to disease. Medicina Intensiva 2016;40(3):169-175
- Picano. Ultrasound of extravascular lung water: a new standard for pulmonary congestion. European Heart Journal 2016;epublished May 12th
- Søreide. Current insight into pathophysiology of gastroduodenal ulcers: Why do only some ulcers perforate? J Trauma 2016;80(6):1045-1048
- Nadim. Management of the critically ill patient with cirrhosis: A multidisciplinary perspective. Journal of Hepatology 2016;64(3):717-735
- Latini. Novel biomarkers and therapies in cardiorenal syndrome. Current Opinion in Pharmacology 2016;27:56-61
- Kushimoto. Lactate, a useful marker for disease mortality and severity but an unreliable marker of tissue hypoxia/hypoperfusion in critically ill patients. Acute Medicine & Surgery 2016;
- Rhee. Gunshot wounds: A review of ballistics, bullets, weapons, and myths. J Trauma 2016;80(6):853-867
- Oode. Horse kick injury mimicking a handle bar injury or a hidden speared injury. Acute Medicine & Surgery 2016;3:3–9
- Dhawan. Medication errors in anesthesia: unacceptable or unavoidable? Brazilian Journal of Anesthesiology 2016;epublished May 16th
- Densham. The emergency laparotomy – principles and perioperative management. Update in Anaesthesia 2016;31:2-8
- Barnett. Developing an effective day surgery service. Update in Anaesthesia 2016;31:9-13
- Hatton-Wyatt. Perioperative management of patients on warfarin and the new oral anticoagulants. Update in Anaesthesia 2016;31:14-23
- Gross. Perioperative acute kidney injury. Update in Anaesthesia 2016;31:24-30
- Edwards. Anaesthetising the malnourished patient. Update in Anaesthesia 2016;31:31-37
- Lyons. Antiemetic drugs: pharmacology and an overview of their clinical use. Update in Anaesthesia 2016;31:38-42
- Cheung. Neck of femur fracture: perioperative management. Update in Anaesthesia 2016;31:43-47
- Molus. Ebola – critical care considerations. Update in Anaesthesia 2016;31:48-54
- Thompson. Peripartum cardiomyopathy. Update in Anaesthesia 2016;31:55-58
- Meaklim. Remote debriefing – a new paradigm for low resource and rural hospitals? Update in Anaesthesia 2016;31:59-62
- Neighbour. Affordable CPAP in low income countries. Update in Anaesthesia 2016;31:63-65
- Neice. Alternatives to traditional fibreoptic bronchoscopes for use in resource-poor settings. Update in Anaesthesia 2016;31:66-67
- Chapman. Cerebral challenge. Update in Anaesthesia 2016;31:68-74
All Articles in a single pdf - Update in Anaesthesia 31
- Villa. The Pathophysiological Hypothesis of Kidney Damage during Intra-Abdominal Hypertension. Front. Physiol 2016;7:55
- Moore. Gun violence in the United States: A call to action. J Trauma 2016;80(6):847-848
- Vincent. The Clinical Challenge of Sepsis Identification and Monitoring. PLoS Med 2016;13(5): e1002022
- Barbui. Sharing all types of clinical data and harmonizing journal standards. BMC Medicine 2016;14:63
- Piddock. Reflecting on the final report of the O'Neill Review on Antimicrobial Resistance. Lancet Infect Dis 2016;epublished May 18th
- Vickers. Sharing raw data from clinical trials: what progress since we first asked “Whose data set is it anyway?” Trials 2016;17:227
- Tyson. Stopping guidelines for an effectiveness trial: what should the protocol specify? Trials 2016;17:240
- Ioannidis. Stealth Research and Theranos. Reflections and Update 1 Year Later. JAMA 2016;epublished May 18th
There is only one month to SMACC DUB. If you haven't yet booked your pre-conference workshop, then the "Stop Gambling - Applying Evidence to Practice" session comes highly recommended (...cough...). You will be encouraged to doubt the ground on which you stand, then come to terms with how we handle that uncertainty in real life practice – without becoming a nihilist.
The Irish Critical Care-Clinical Trials Group (ICC-CTG) host a two hour meeting in conjunction with the Intensive Care Society of Ireland Annual Meeting in the AVIVA Stadium on Saturday June 11th and two Clinical Research Foundation Workshops on Sunday June 12th & Monday June 13th. A distinguished international panel of guests will be present to demonstrate how a CTG functions and what each unit needs to know. In addition, this meeting provides the opportunity to network and keep up to speed with the ICC-CTG's current and future trials portfolio.
A networking dinner will be hosted on Monday 13th June in Sophie's Restaurant at The Dean Hotel. These meetings will be immediately before SMACC Dub and may also be of interest to those visiting Dublin. The registration fee is €50 and includes lunch & refreshments throughout the day. Book before 1st May to avail of the Early Bird option of €30 (limited availability).
Please contact Louise at firstname.lastname@example.org to register for the meeting and meal.
The Summer Scientific Meeting of the Intensive Care Society is on Saturday June 11th at the Aviva Stadium, the home of Irish Rugby and Soccer. The theme is toxicology and features several of the SMACC faculty who will be in town that weekend. The meeting programme and registration are available on the brand new, and beautiful, Intensive Care Society of Ireland website.
The 9th UK Critical Care Research Forum is being held on 23rd – 24th June 2016 at the Sage Gateshead, with over 20 research proposals as well as sessions on adaptive trial design, international collaborations in critical care trials and patient-centred research. There is also a Forum dinner at the Baltic Centre for Contemporary Art. Registration is now open.
(image from Wikimedia)
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. The website has caught a cold, but will be back up very soon.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week