Welcome to the 226th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The big news this week is the announcement of the speakers to date for the Critical Care Reviews Meeting 2017 and the opening of delegate registration.
Once again, our speakers come from across the world. Mervyn Singer (London) will explain the new sepsis 3.0 definition, which is already the most downloaded paper in the history of JAMA. Greet Van den Berghe (Belgium) will present the PEPaNIC trial, comparing early with late initiation of parenteral nutrition in critically ill children. Gonzalo Hernandez (Madrid) will explain his study examing the role of high flow nasal oxygen in extubated patients at low risk for reintubation. Returning for the second year in a row, Anthony Gordon will speak about his latest, and yet to publish, LEOPARDS trial, investigating levosimendan in septic shock. In addition, travelling from the world famous George Institute in Sydney, Australia, is John Myburgh, and from Virginia, USA, Paul Marik. The faculty is not yet complete and will continue to grow as the best critical care trials are published during the year. Fittingly, as we announce our return to the magnificent Titanic Centre in Belfast for #CCR17, today marks the day RMS Titanic sailed on her maiden voyage.
The highlight of this week's newsletter is the publication of the ALPS study, evaluating antiarrhythmics in cardiac arrest. There are many fantastic review articles this week, but if you only have time to read one, try either this paper on Intensive Care Unit Acquired Weakness or this paper on the standard of care of patients with ARDS.
I haven't had time to put together the Topic of the Week yet, so I'll publish this tomorrow.
- Full Text: Kudenchuk. Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. N Engl J Med 2016;epublished April 4th
- Full Text: Velazquez. Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy (STICHES Trial). N Engl J Med 2016;epublished April 3rd
- Full Text: O’Donoghue. Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction. A Randomized Clinical Trial (LATITUDE-TIMI 60 Trial). JAMA 2016;epublished April 4th
- Full Text: Patel. Ixmyelocel-T for patients with ischaemic heart failure: a prospective randomised double-blind trial. Lancet 2016;epublished April 4th
- Abstract: Kelbæk. Deferred versus conventional stent implantation in patients with ST-segment elevation myocardial infarction (DANAMI 3-DEFER): an open-label, randomised controlled trial. Lancet 2016;epublished April 3rd
- Full Text: Deschamps. Cerebral Oximetry Monitoring to Maintain Normal Cerebral Oxygen Saturation during High-risk Cardiac Surgery: A Randomized Controlled Feasibility Trial. Anesthesiology 2016;124:826-836
- Full Text: Donnino. Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial. Critical Care 2016;20:82
- Abstract: Zeng. Effect of probiotics on the incidence of ventilator-associated pneumonia in critically ill patients: a randomized controlled multicenter trial. Intensive Care Med 2016;epublished April 4th
- Abstract: Pang. Therapeutic hypothermia in adult patients receiving extracorporeal life support: early results of a randomized controlled study. Journal of Cardiothoracic Surgery 2016;11:43
- Abstract: Stone. Relationship Between Infarct Size and Outcomes Following Primary PCI. A Patient-Level Analysis From 10 Randomized Trials. J Am Coll Cardiol 2016;67(14):1674-1683
- Abstract: Xu. The Effect of Early Goal-Directed Therapy on Outcome in Adult Severe Sepsis and Septic Shock Patients: A Meta-Analysis of Randomized Clinical Trials. Anesth Analg 2016;epublished April 5th
- Abstract: Yang. A Meta-analysis of Intraoperative Ventilation Strategies to Prevent Pulmonary Complications: Is Low Tidal Volume Alone Sufficient to Protect Healthy Lungs? Annals of Surgery 2016;263(5):881–887
- Full Text: Andersen. Early administration of epinephrine (adrenaline) in patients with cardiac arrest with initial shockable rhythm in hospital: propensity score matched analysis. BMJ 2016;353:i1577
- Full Text: Bradley. Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry. BMJ 2016;353:i1653
- Full Text: Zander. Piperacillin concentration in relation to therapeutic range in critically ill patients – a prospective observational study. Critical Care 2016;20:79
- Abstract: Reuben. Outcomes in Adults With Acute Liver Failure Between 1998 and 2013: An Observational Cohort Study. Ann Intern Med 2016;epublished April 5th
- Abstract: dos Santos. Mechanisms of Chronic Muscle Wasting and Dysfunction After an Intensive Care Unit Stay: A Pilot Study. Am J Respir Crit Care Med 2016;epublished April 8th
- Norman. Antibiotics and antiseptics for pressure ulcers. Cochrane Database of Systematic Reviews 2016, Issue 4. Art. No.: CD011586
- Sud. High-frequency oscillatory ventilation versus conventional ventilation for acute respiratory distress syndrome. Cochrane Database of Systematic Reviews 2016, Issue 4. Art. No.: CD004085
- Jolley. Intensive Care Unit Acquired Weakness. Chest 2017;epublished April 7th
- Huang. Nitrous Oxide, From the Operating Room to the Emergency Department. Current Emergency and Hospital Medicine Reports 2016;4(1):11-18
- Evans. Current approach to diagnosis and treatment of delirium after cardiac surgery. Ann Card Anaesth 2016;19:328-37
- Yuan. Myocardial Bridging. Braz J Cardiovasc Surg 2016;31(1):60-62
- Floré. The Rise and Fall of Routine Manual Thrombectomy for ST-Elevation Myocardial Infarction. EMJ 2016;1:71-75
- Malhotra. N-terminal pro B type natriuretic peptide in high cardiovascular-risk patients for noncardiac surgery: What is the current prognostic evidence?. Ann Card Anaesth 2016;19:314-20
- Martin. Troponin elevations in patients with chronic cardiovascular disease: An analysis of current evidence and significance. Ann Card Anaesth 2016;19:321-7
- Vazira. Decongestion: Diuretics and other therapies for hospitalized heart failure. Indian Heart Journal 2016;68(1):S61-S68
- Bein. The standard of care of patients with ARDS: ventilatory settings and rescue therapies for refractory hypoxemia. Intensive Care Med 2016;epublished April 4th
- Doorduin. The differential diagnosis for failure to wean from mechanical ventilation. Curr Opin Anaesth 2016;29(2):150-157
- Bhattacharya. Negative Pressure Pulmonary Edema. Chest 2017;epublished April 8th
- Kim. Sepsis and Acute Respiratory Distress Syndrome: Recent Update. Tuberc Respir Dis 2016;79(2):53-57
- Romay. Extracorporeal CO2 removal: Technical and physiological fundaments and principal indications. Med Intensiva 2016;40:33-8
- Delnoij. Venovenous Extracorporeal Membrane Oxygenation in Intractable Pulmonary Insufficiency: Practical Issues and Future Directions. BioMed Research International 2016;2016:9367464
- Nassar. Capnography During Critical Illness. Chest 2016;149(2):576-585
- Chung. CPAP in the Perioperative Setting : Evidence of Support. Chest 2016;149(2):586-597
- Mazo. How to optimize and use predictive models for postoperative pulmonary complications. Minerva Anestesiologica 2016;82(3):332-42
- Kumar. Vessels of the Central Airways: A Bronchoscopic Perspective. Chest 2016;149(3):869-881
- Huang. Open abdomen in trauma patients: a double-edged sword. Mil Med Res 2016;3:10
- O'Neal. Critical Illness in Patients with Asplenia. Chest 2017;epublished April 9th
- Annetta. Immunonutrients in critically ill patients: an analysis of the most recent literature. Minerva Anestesiologica 2016;82(3):320-31
- Suetrong. Lactic Acidosis in Sepsis: It’s Not All Anaerobic: Implications for Diagnosis and Management. Chest 2016;149(2):252-261
- Levy. Antithrombin: anti-inflammatory properties and clinical applications. Thromb Haemost 2016;115 4:712-728
- Douglas. The role of genomics to identify biomarkers and signaling molecules during severe sepsis. Minerva Anestesiologica 2016;82(3):343-58
- Loftus. Infection control in the operating room: is it more than a clean dish? Curr Opin Anaesth 2016;29(2):192-197
- Hiemstra. Antimicrobial Peptides and Innate Lung Defenses: Role in Infectious and Noninfectious Lung Diseases and Therapeutic Applications. Chest 2016;149(2):545-551
- Wilson. Extensively Drug-Resistant Tuberculosis. Principles of Resistance, Diagnosis, and Management. Mayo Clin Proc. 2016;91(4):482-495
- Brade. Oritavancin: A New Lipoglycopeptide Antibiotic in the Treatment of Gram-Positive Infections. Infectious Diseases and Therapy 2016;5(1):1-15
- Takazawa. Sugammadex and rocuronium-induced anaphylaxis. J Anesth 2016;30(2):290-297
- Kennedy. Immunology for Anaesthetists Part 2: Hypersensitivity Reactions. Anaesthetic Tutorial of the Week 2016;epublished April 7th
- Lorente. Update in the management of critically ill burned patients. Med Intensiva 2016;40:46-8
- Vivó. Initial evaluation and management of the critical burn patient. Med Intensiva 2016;40:49-59
- Bassetti. Focus on antimicrobial use in the era of increasing antimicrobial resistance in ICU. Intensive Care Med 2016;epublished 4th
- Bhaskar. The transversus abdominis plane block: Case for optimal tap. Indian J Anaesth 2016;60:231-3
- Mishra. Upscaling cardiac assist devices in decompensated heart failure: Choice of device and its timing. Indian Heart Journal 2016;68(1):S1-S4
- Eckle. Delirium - A Dysfunctional Circadian Rhythm. Int J Anesth Res 2016;4(1e):1-3
- Curtis. The importance and challenge of measuring family experience with end-of-life care in the ICU. Intensive Care Med 2016;epublished April 7th
- Long. Addressing uncertainty: what is the role of consensus in end-of-life care? Intensive Care Med 2016;epublished April 7th
- Gattinoni. How ARDS should be treated. Critical Care 2016;20:86
- Kapoor. Echocardiography for cardiac tamponade. Ann Card Anaesth 2016;19:338
- Kapoor. Echocardiography for residual VSD. Ann Card Anaesth 2016;19:339
- Cyrille. Soluble urokinase plasminogen activation receptor - An emerging new biomarker of cardiovascular disease and critical illness. Ann Card Anaesth 2016;19:214-6
- Fochi. Ultrasonographic diagnosis of tracheal compression. Intensive Care Medicine 2016;epublished March 31st
- Banauch. A 33-Year-Old Man With a History of Intravenous Drug Use and Fevers. Chest 2016;149(3):e75-e77
- Kyaw. A 45-Year-Old Woman With 3 Weeks of Cough and Night Sweats. Chest 2016;149(3):e87–e90
- Breuer. Hepatopulmonary Syndrome in Patients With Cystic Fibrosis and Liver Disease. Chest 2016;149(2):e35-e38
- Bourne. Two Patients With Hypotension and Respiratory Distress. Chest 2016;149(2):e41–e43
- Dugar. Middle-Aged Woman With Shock. Chest 2016;149(2):e45–e47
- Greenstein. A Man in His 60s With Circulatory Collapse. Chest 2016;149(1):e11–e16
- Qu. Survival of a newborn from a pregnant woman with rabies infection. Journal of Venomous Animals and Toxins including Tropical Diseases 2016;22:14
The not-for-profit foundation, Fundación de Cuidados Críticos, formed by physicians working in the ICU of the Hospital Italiano de Buenos Aires, are holding their 6th annual symposium on critical care in Buenos Aires. This is a multidisciplinary 3 day symposium dealing with several key topics in current critical care. It is free of charge to attend and will be held in the Palais Rouge, a beautiful three stories building in Buenos Aires, Argentina. ,
Day 1 (April 13th) deals with the ABCDE approach, post ICU syndrome, family involvement in everyday practice and the best strategies to minimize sedation and ICU delirium, as well as a separate session on shock and an ultrasound workshop. The whole evening will be spent dealing with current and up-to-date critical care nursing issues. Day 2 (April 14th) deals with pulmonology, new ways to monitor mechanical ventilation, capnography, electrical impedance tomography, and other key issues. The guest speaker is Arnaud Thille from France. Other topics on day 2 include burns and the ERAS approach to post-operative patients. Day 3 (April 15th) continues with pulmonology and other critical care issues, as well as nutritional support, and quality improvement in ICU.
The next SMACC Conference is on June 13th to 16th, in Dublin, Ireland. Registration opened on October 28th, sold out in a few hours, and closed again. Luckily, there are two further smaller batches of tickets available on Wednesday December 2nd and Wednesday February 3rd. With world leading academics and high profile clincians from the FOAMed critical care world, this conference fuses knowledge, dynamism and enthusiasm with an altruisitic desire to be the best we can be for the benefit of our patients. It's the most fun, modern critical care conference in the world. If you've been lucky enough to register for #smaccDUB, the presentations from SMACC Chicago, which are now online at Intensive Care Network, will give you an idea as to what to expect.
(Image from Wikimedia)
The Irish Critical Care-Clinical Trials Group (ICC-CTG) host a two hour meeting in conjunction with the Intensive Care Society of Ireland Annual Meeting in the AVIVA Stadium on Saturday June 11th and two Clinical Research Foundation Workshops on Sunday June 12th & Monday June 13th. A distinguished international panel of guests will be present to demonstrate how a CTG functions and what each unit needs to know. In addition, this meeting provides the opportunity to network and keep up to speed with the ICC-CTG's current and future trials portfolio.
A networking dinner will be hosted on Monday 13th June in Sophie's Restaurant at The Dean Hotel. These meetings will be immediately before SMACC Dub and may also be of interest to those visiting Dublin. The registration fee is €50 and includes lunch & refreshments throughout the day. Book before 1st May to avail of the Early Bird option of €30 (limited availability).
Please contact Louise at email@example.com to register for the meeting and meal.
The Summer Scientific Meeting of the Intensive Care Society is on Saturday June 11th at the Aviva Stadium, the home of Irish Rugby and Soccer. The theme is toxicology and features several of the SMACC faculty who will be in town that weekend. Registration hasn't yet opened, but the meeting programme is available here.
The 13th Annual Critical Care Symposium is on April 28th and 29th in Manchester Town Hall, England. This meeting aims to bring together world renowned speakers for a conference outside London and to provide a conducive environment allowing informal discussion. Most importantly, this event provides good quality education covering various topics in Intensive Care at an affordable price.
The 9th UK Critical Care Research Forum is being held on 23rd – 24th June 2016 at the Sage Gateshead, with over 20 research proposals as well as sessions on adaptive trial design, international collaborations in critical care trials and patient-centred research. There is also a Forum dinner at the Baltic Centre for Contemporary Art. Registration is now open.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week