Welcome to the 182nd Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.
It's a relatively small newsletter this week as I been travelling with limited internet access. The highlights of this week's newsletter are randomized controlled trials on Effect of remote Ischemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery and Talactoferrin in Severe Sepsis, a guideline on the Management of Spontaneous Intracerebral Hemorrhage plus review articles on De Novo Acute Heart Failure and Acutely Decompensated Chronic Heart Failure, Ventilatory targets after cardiac arrest, Feeding critically ill patients the right "whey" and The role of beta-blockers in septic patients. If you only have time for one review article, check out this paper on mesenchymal stromal cells for treatment of the acute respiratory distress syndrome: The beginning of the story.
- Full Text: Zarbock. Effect of Remote Ischemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery. A Randomized Clinical Trial. JAMA 2015;epublished May 29th
- Abstract: Hooper. Pleural irrigation trial (PIT): a randomised controlled trial of pleural irrigation with normal saline versus standard care in patients with pleural infection. Eur Respir J 2015;epublished May 28th
- Abstract: Vincent. Talactoferrin in Severe Sepsis: Results From the Phase II/III Oral tAlactoferrin in Severe sepsIS Trial. Crit Care Med 2015;epublished May 22nd
- Abstract: Wu. Randomized Controlled Trial to Evaluate Regional Citrate Anticoagulation Plus Low-Dose of Dalteparin in Continuous Veno-Venous Hemofiltration. Blood Purif 2015;39:306-312
- Abstract: Wang. Comparisons between small intestinal and gastric feeding in severe traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials. J Neurosurg 2015;29:1-8
- Abstract: Yu. The role of the induction of mild hypothermia in adult patient outcomes after cardiac arrest: Systematic review and meta-analysis of randomized controlled studies. Journal of International Medical Research 2015;epublished May 26th
- Abstract: Spencer. Longer Versus Shorter Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis. Ann Intern Med 2015;epublished May 26th
- Full Text: Duggal. Pharmacological treatments for acute respiratory distress syndrome: systematic review. Minerva Anestesiologica 2015;81(5):567-88
- Full Text: Long. Positive End-expiratory Pressure Titration after Alveolar Recruitment Directed by Electrical Impedance Tomography. Chin Med J (Engl) 2015;128(11):1421-1427
- Abstract: Lima. Inter-rater Reliability and Diagnostic Performance of Subjective Evaluation of Sublingual Microcirculation Images by Physicians and Nurses: A Multicenter Observational Study. Shock 2015;epublshed May 22nd
- Full Text: Chalasani. Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study. Gastroenterology 2015;148(7):1340-1352.e7
- Abstract: Lammi. Response to Fluid Boluses in the Fluid and Catheter Treatment Trial. Chest 2015;epublished May 28th
- Full Text: Le Moing. Staphylococcus aureus Bloodstream Infection and Endocarditis - A Prospective Cohort Study. PLoS One 2015;10(5):e0127385
- Abstract: Wolters. Anticholinergic Medication Use and Transition to Delirium in Critically Ill Patients: A Prospective Cohort Study. Crit Care Med 2015;epublished May 22nd
- Abstract: Bouadma. Ventilator-Associated Events: Prevalence, Outcome, and Relationship With Ventilator-Associated Pneumonia. Crit Care Med 2015;epublished May 14th
- Sonderer. Aetiological blood biomarkers of ischaemic stroke. Swiss Med Wkly 2015;145:w14138
- Stoeter. Managing acute central nervous system infections in the UK adult intensive care unit in the wake of UK encephalitis guidelines. JICS 2015;epublished May 28th
- Hummel. De Novo Acute Heart Failure and Acutely Decompensated Chronic Heart Failure. Dtsch Arztebl Int 2015;112(17):298-310
- Guarracino. Revised ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management. Implications for preoperative clinical evaluation. Minerva Anestesiologica 2015;81(2):226-33
- Morrison. Mesenchymal stromal cells for treatment of the acute respiratory distress syndrome: The beginning of the story. JICS 2015;epublished May 21st
- Sutherasan. Ventilatory targets after cardiac arrest. Minerva Anestesiologica 2015;81(1):39-51
- Squizzato. Point-of-care ultrasound in the diagnosis of pulmonary embolism. Critical Ultrasound Journal 2015;7:7
- Agrò. Use of GlideScope® in adults: an overview. Minerva Anestesiologica 2015;81(3):342-51
- Masterson. Mesenchymal stromal cell therapies: potential and pitfalls for ARDS. Minerva Anestesiologica 2015;81(2):179-94
- Ochiai. Mechanical ventilation of acute respiratory distress syndrome. Journal of Intensive Care 2015;3:25
- Huetsch. Na+/H+ exchange and hypoxic pulmonary hypertension. Pulmonary Circulation 2015;5(2):228-243
- Kholdani. Pulmonary hypertension in obstructive sleep apnea: is it clinically significant? A critical analysis of the association and pathophysiology. Pulmonary Circulation 2015;5(2):220-227
- Funke. Idiopathic pulmonary fibrosis: the turning point is now! Swiss Med Wkly 2015;145:w14139
- Marik. Feeding critically ill patients the right `whey: thinking outside of the box. A personal view. Annals of Intensive Care 2015;5:11
- Çağlı. How to interpret liver function tests in heart failure patients? Turk J Gastroenterol 2015;26(3):197-203
- Araz. New modalities in the treatment of HCV in pre and post - transplantation setting. Turk J Gastroenterol 2015;26:204-213
- Meyer. A review of renal protection strategies. South Afr J Anaesth Analg 2015;21(2):5-8
- Degrassi. Imaging of haemodialysis: renal and extrarenal findings. Insights Imaging 2015;6:309–321
- Olesen. Stroke risk in atrial fibrillation: Do we anticoagulate CHADS2 or CHA2DS2-VASc ≥1, or higher? Thromb Haemost 2015;113(6):1165-1169
- Nielsen. The risks of risk scores for stroke risk assessment in atrial fibrillation. Thromb Haemost 2015;113(6):1170-1173
- Goldhaber. Venous thromboembolism: “…an ounce of prevention is worth a pound of cure”. Thromb Haemost 2015;113(6):1174-1175
- Riva. Epidemiology and pathophysiology of venous thromboembolism: similarities with atherothrombosis and the role of inflammation. Thromb Haemost 2015;113(6):1176-1183
- Righini. Venous thromboembolism diagnosis: unresolved issues. Thromb Haemost 2015;113(6):1184-1192
- Hillis. Acute phase treatment of VTE: Anticoagulation, including non-vitamin K antagonist oral anticoagulants. Thromb Haemost 2015;113(6):1193-1202
- Konstantinides. Acute phase treatment of venous thromboembolism: advanced therapy. Systemic fibrinolysis and pharmacomechanical therapy. Thromb Haemost 2015;113(6):1202-1209
- Prandoni. Optimal duration of anticoagulation. Provoked versus unprovoked VTE and role of adjunctive thrombophilia and imaging tests. Thromb Haemost 2015;113(6):1210-1215
- Granziera. VTE primary prevention, including hospitalised medical and orthopaedic surgical patients. Thromb Haemost 2015;113(6):1216-1223
- De Backer. Assessment of microperfusion in sepsis. Minerva Anestesiologica 2015;81(5):533-40
- Mallat. Difference in venous-arterial carbon dioxide in septic shock. Minerva Anestesiologica 2015;81(4):419-25
- Hamers. Sepsis-induced immunoparalysis: mechanisms, markers, and treatment options. Minerva Anestesiologica 2015;81(4):426-39
- Hamzaoui. The role of beta-blockers in septic patients. Minerva Anestesiologica 2015;81(3):312-9
- Grossi. Novel multidrug resistant microorganisms in critically ill: a potential threat. Minerva Anestesiologica 2015;81(1):52-64
- Bassetti. Antimicrobial prophylaxis in minor and major surgery. Minerva Anestesiologica 2015;81(1):76-91
- Walsh. What are the priorities for future success in critical care research in the UK? Report from a national stakeholder meeting. JICS 2015;epublished May 28th
- Lanini. Are adaptive randomised trials or non-randomised studies the best way to address the Ebola outbreak in west Africa? Lancet Infctious Diseases 2015;15(6):738–745
Due to hugely successful previous events, the Critical Care Reviews Meeting 2016 has been moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic, As before, the meeting theme is to review the biggest studies of the previous year, with chief investigators present where possible to discuss their work in person. From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. Similarly, Prof Danny McAuley (Belfast, Northern Ireland) will also review a post-ICU rehab study, the REVIVE trial. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. The finalised programme won't be released until later this Autumn, but don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.
There are just three weeks to one of the biggest, and definitely the best, critical care conference in the world. The next SMACC Conference is on June 23rd to 26th, in Chicago, USA. With its informal manner and flat hierarchy, this event delivers on its promise to provide top class critical care education in a fun, modern way. Speakers are deliberately chosen for their ability to present and convey information, rather than their academic or social media status, marking this as the field leader in medical conferencing. With an emphasis on TED-like presentation styles, minimal slides and maximal social media involvement, this is the future of medical meetings. In addition to numerous world-leading academics, many active in the altruistic social media world of FOAM are there to contribute, including helping deliver a massive set of workshops the day before the main meeting begins. In the main programme, I'll be giving a talk on kicking perioperative goals, and also debating Prof Paul Marik on the usefulness, or not, of predicting fluid responsiveness. I hope to see you there - I'll need all the support I'll can get!
This year's State-of-the-Art Meeting promises an exciting programme in a new dynamic format. With strong social media input, and fresh ideas from those successfully delivering free educational content through various FOAM websites and events, this conference will be very different to before. Covering every CPD requirement, and attracting the most eminent researchers from the UK and beyond, the State-of-the-Art meeting remains the biggest critical care conference in the UK. I'll be on the debate trail again, taking on two world experts in respiratory failure, Dr Eddy Fan and Prof Luciano Gattinoni.
The ICSI host a superb three day ESICM meeting at Dubin Castle on June 11th to 13th, focusing on every aspect of respiratory critical care. From mechanical ventilation to ARDS to heart-lung interactions, this event is ideal for anyone interested in updating their knowledge in this field, under the guidance of some of the leading names in the area.
After almost a year of preparation, the first issue of the new genuine open access critical care journal, Critical Care Horizons, is just a few weeks from publication. This is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have something interesting to say, and can say it in an engaging manner, please get in touch.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week