Mervyn Singer discusses the Sepsis 3 definition
Welcome to the 271st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this weeks newsletter are the HYPERS2S trial, examining hyperoxia and hypertonic saline in septic shock, a randomised controlled trial investigating the effect of a condolence letter on grief symptoms among relatives of patients who died in the ICU; editorials on whether all patients with sepsis should receive anticoagulation and a commentary on nonreproducibility in basic and preclinical research. If you only have time for one review article this week, try either this paper on the significance of circadian rhythms and dysrhythmias in critical illness or this one on postoperative pulmonary complications.
This week's Topic of the Week is a selection of papers on aortic arch surgery, starting with a paper on immediate ICU care for patients following aortic arch surgery in tomorrow's Paper of the Day.
The talks from the Critical Care Reviews Meeting 2017 are now being sequentially released, with one out every Sunday and Wednesday until the entire series has been posted. First up is Mervyn Singer with a discussion on the SEPSIS 3.0 definition. Finally, the podcast versions of the talks are available too.
- Abstract: Asfar. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial. Lancet respir Med 2017;epublished February 14th
- Abstract: Kentish-Barnes. Effect of a condolence letter on grief symptoms among relatives of patients who died in the ICU: a randomized clinical trial. Intensive Care Med 2017;epublished February 14th
- Full Text: Moghaddam. Early administration of selenium in patients with acute traumatic brain injury: A randomized double-blinded controlled trial. Indian J Crit Care Med 2017;21:75-9
- Abstract: Mistraletti. Neurological assessment with validated tools in general ICU: multicenter, randomized, before and after, pragmatic study to evaluate the effectiveness of an e-learning platform for continuous medical education. Minerva Anestesiologica 2017;83(2):145-54
- Abstract: Colomina. Intraoperative tranexamic acid use in major spine surgery in adults: a multicentre, randomized, placebo-controlled trial. Br J Anaesth 2017;118(3):380-390
- Abstract: Booth. SponTaneous Respiration using IntraVEnous anaesthesia and Hi-flow nasal oxygen (STRIVE Hi) maintains oxygenation and airway patency during management of the obstructed airway: an observational study. Br J Anaesth 2017;118(3):444-451
- Abstract: Joosten. Accuracy and precision of non-invasive cardiac output monitoring devices in perioperative medicine: a systematic review and meta-analysis. Br J Anaesth 2017;118(3):298-310
- Full Text: Grunewald. Analgesia/nociception monitoring for opioid guidance: meta-analysis of randomized clinical trials. Minerva Anestesiologica 2017;83(2):200-13
- Full Text: Ghijselings. Safety of gelatin solutions for the priming of cardiopulmonary bypass in cardiac surgery: a systematic review and meta-analysis. Perfusion 2017;epublished January 3rd
- Full Text: Crewdson. The success of pre-hospital tracheal intubation by different pre-hospital providers: a systematic literature review and meta-analysis. Critical Care 2017;21:31
- Abstract: Zhao. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. Am J Respir Crit Care Med 2017;195(4):482-490
- Abstract: de Montmollin. Anti–N-Methyl-d-Aspartate Receptor Encephalitis in Adult Patients Requiring Intensive Care. Am J Respir Crit Care Med 2017;195(4):491-499
- Abstract: Fernandez-Bustamante. Postoperative Pulmonary Complications, Early Mortality, and Hospital Stay Following Noncardiothoracic SurgeryA Multicenter Study by the Perioperative Research Network Investigators. JAMA Surg. 2017;152(2):157-166
- Abstract: Moskowitz. Thiamine as a Renal Protective Agent in Septic Shock: A Secondary Analysis of a Randomized, Double-Blind, Placebo-Controlled Trial. Ann Am Thorac Soc 2017;epublished February 16th
- Abstract: Darweesh. Effect of N-Acetylcysteine on Mortality and Liver Transplantation Rate in Non-Acetaminophen-Induced Acute Liver Failure: A Multicenter Study. Clin Drug Investig 2017;epublished February 15th
- Abstract: Boissier. Left ventricular systolic dysfunction during septic shock: the role of loading conditions. Intensive Care Med 2017;epublished February 15th
- Abstract: Bouvet. Prevalence and factors predictive of full stomach in elective and emergency surgical patients: a prospective cohort study. Br J Anaesth 2017;118(3):372-379
- Abstract: Staufer. Renal replacement therapy in critically ill liver cirrhotic patients - Outcome and Clinical Implications. Liver Int 2017;epublished February 16th
- Mappus. The use of desmopressin acetate in patients presenting with intracranial hemorrhage: A review. Trauma 2017;19(1):3-10
- Law. Treatment of intracerebral haemorrhage with tranexamic acid – A review of current evidence and ongoing trials. European Stroke Journal 2017;2(1):13–22
- Martin. A review of perioperative anesthesia and analgesia for infants: updates and trends to watch. F1000Research 2017, 6(F1000 Faculty Rev):120
- Neri. Ischemia/Reperfusion Injury following Acute Myocardial Infarction: A Critical Issue for Clinicians and Forensic Pathologists. Mediators of Inflammation 2017;2017:7018393
- Nii-Trebi. Emerging and Neglected Infectious Diseases: Insights, Advances, and Challenges. BioMed Research International 2017;(2017):5245021
- Singh. Agents with vasodilator properties in acute heart failure. Eur Heart J 2017;38(5):317-325
- Al-Atassi. Indications for Aortic Arch Intervention. Semin Cardiothorac Vasc Anesth 2016;20(4):259–264
- Wilkey. Anesthetic Considerations for Surgery on the Aortic Arch. Semin Cardiothorac Vasc Anesth 2016;20(4):265-272
- Chen. Temperature Management for Aortic Arch Surgery. Semin Cardiothorac Vasc Anesth 2016;20(4):283–288
- Mosca. A Clinical Protocol for Goal Directed Cerebral Perfusion during Aortic Arch Surgery. Semin Cardiothorac Vasc Anesth 2016;20(4):289–297
- Foley. Arterial Cannulation and Cerebral Perfusion Strategies for Aortic Arch Operations. Semin Cardiothorac Vasc Anesth 2016;20(4):298–302
- Sing. Hemiarch. The Real Operation for Ascending Aortic Aneurysm. Semin Cardiothorac Vasc Anesth 2016;20(4):303–306
- Shelstad. Total Aortic Arch Replacement. Advantages of Varied Techniques. Semin Cardiothorac Vasc Anesth 2016;20(4):307–313
- de la Cruz. Aortic Arch Replacement in Patients With Chronic Dissection. Special Considerations. Semin Cardiothorac Vasc Anesth 2016;20(4):314–321
- Tanaka. Elephant Trunk. Argument for All Arches. Semin Cardiothorac Vasc Anesth 2016;20(4):322–326
- Sultan. Hybrid Techniques for Aortic Arch Aneurysm Repair. Sultan327–332
- Hlaing. Immediate ICU Care for Patients Following Aortic Arch Surgery. Semin Cardiothorac Vasc Anesth 2016;20(4):333–342
- Miskovic. Postoperative pulmonary complications. Br J Anaesth 2017;118(3):317-334
- Spapen. Chest physiotherapy in mechanically ventilated patients without pneumonia—a narrative review. J Thorac Dis 2017;9(1):E44-E49
- Zhou. Current treatment of tracheoesophageal fistula. Ther Adv Respir Dis 2017;epublished February 13th
- Zhao. Update on the diagnosis and treatment of tracheal and bronchial injury. J Thorac Dis 2017;9(1):E50-E56
- Madden. Evolutional trends in the management of tracheal and bronchial injuries. J Thorac Dis 2017;9(1):E67-E70
- Heyland. Proceedings of the 2016 Clinical Nutrition Week Research Workshop—The Optimal Dose of Protein Provided to Critically Ill Patients. How Do We Know When Enough Is Enough? Journal of Parenteral and Enteral Nutrition 2017;41(2):208-216
- Patel. Protein Requirements for Critically Ill Patients With Renal and Liver Failure. Nutr Clin Pract 2017;epublished February 16th
- Moore. Nutrition Support for Persistent Inflammation, Immunosuppression, and Catabolism Syndrome. Nutr Clin Pract 2017;epublished February 6th
- Shaikh. Perioperative considerations and management of patients receiving anticoagulants. Anesth Essays Res 2017;11:10-6
- Ginsburg. From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective. J Inflamm Res 2017;10:7–15
- Olthof. Evidence-Based Management and Controversies in Blunt Splenic Trauma. Curr Trauma Rep 2017;epublished February 9th
- Kornhall. The prehospital management of avalanche victims. J R Army Med Corps 2016;162(6):406-412
- Mason. Paediatric emergence delirium: a comprehensive review and interpretation of the literature. Br J Anaesth 2017;118(3):335-343Br J Anaesth 2017;118(3):335-343
- Yuki. Pediatric Perioperative Stress Responses and Anesthesia. Transl Perioper Pain Med 2017;2(1):1–12
- Meziani. Should all patients with sepsis receive anticoagulation? Yes. Intensive Care Med 2017;epublished February 13th
- van der Poll. Should all septic patients be given systemic anticoagulation? No. Intensive Care Med 2017;epublished February 13th
- Janssens. Coronary angiography and percutaneous coronary intervention after out-of-hospital cardiac arrest: major leaps towards improved survival? J Thorac Dis 2017;9(1):5-7
- Prowle. Validating benefit of biomarker-directed therapy for acute kidney injury: can you have your cake and eat it? Intensive Care Med 2017;epublished February 16th
- Bernhardt. Early mobilisation and rehabilitation in intensive care unit—ready for implementation? Ann Transl Med 2017;5(3):57
- Vincent. The challenge of early identification of the hospital patient at risk of septic complications. Ann Transl Med 2017;5(3):56
- Simpson. Diagnosing sepsis: a step forward, and possibly a step back. Ann Transl Med 2017;5(3):55
There are just 5 months left unit Das SMACC and all tickets have now been sold for the main conference. If you are interested in attending the workshops, there are a very small number of tickets left for the Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong. With a superb international faculty, this half-day event will address your burning critical care questions.
The Canadian Critical Care Conference (www.canadiancriticalcare.CA; @CriticalCareCa) is rather special. Not only a spectacular location (world famous Whistler, British Columbia, Canada) but also the world's finest downhill skiing, cross-country skiing, and mountain village location (did we mention it's in Whistler?). Located at the lovely Four Seasons Resort, we offer a meeting crammed with world renown speakers but in a more laid back, interactive, and reinvigorating setting that your typical medical conference. We cover all of the core science and latest research, but do not shy away from all those topics that make for a great, or not so great, patient care. This includes human factors, burnout and resilience, end-of-life care, multidisciplinary care, social media, organ donation, and the patient perspective. We are always kean to engage trainees and nurses, we offer world class precourses, and we ensure time to enjoy all that makes Whistler and Blackcomb so special. We have no desire to be the world's largest acute care conference. Rather we want to create something unique: an opportunity to learn; to interact, to have fun, and to leave more refreshed and engaged. Come and join us.
(Image from Chensiyuan via Wikipedia)
The Critical Care Symposium (CCS) was initiated to satisfy the purpose of creating a world-class environment for medical enrichment in the North of England, particularly in Manchester. It was envisioned as a common informal platform wherein professionals from the field of critical care could provide and enhance the knowledge of delegates on current practices and related fields of interest.
Now in its 14th year, the annual conference regularly has renowned speakers from around the world and attracts more than 400 delegates. And this year is no different. In recent years a parallel course on ultrasound has been conducted alongside the conference that provides ample hand-on experience over two days. This year will host the 7th Ultrasound in Acute Care. For more information please visit http://critcaresymposium.co.uk.
The ANZICS/ACCCN Annual Scientific Meeting, which incorporates the annual Paediatric and Neonatal Intensive Care Conference, will be held at the Gold Coast Convention and Exhibition Centre, 11-13 October 2017. The Annual Scientific Meeting will be the preeminent critical care conference in Australasia for the calendar year and will be an important platform that will allow doctors, nurses and allied health practitioners to meaningfully connect and discuss new developments and research in the field of intensive and critical care.
The theme of the Meeting is “Thinking Outside the Flags” and will focus upon innovative and challenging advances that lie outside the safe zone of current practice, as well as the potential dangers that they may bring. A number of highly regarded international speakers will join our distinguished national and local speakers, experts in the field of intensive care medicine, nursing and allied health, promising delegates an exciting and challenging program.
Registration and the call for abstracts will open on 20 March 2017. For further information or to express your interest in attending, please visit http://intensivecareasm2017.com.au/.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week