Welcome to the 266th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. Apologies for being a couple of days late, but I've been tied up with finishing the Critical Care Reviews Book 2017. Along with 4 friends we've reviewed the best critical care trials of 2016. It's been a lot of work but will be a fantastic resource for anyone looking to stay up-to-date with the literature. The book will be released at the Critical Care Reviews Meeting next week, with all delegates getting a complimentary print copy. It will be available as a free pdf download on the website the same day.
This newsletter is a bit small, but still has some great articles in it, including two studies evaluating the latest Sepsis 3 definition. I'll put the Topic of the Week up tomorrow.
- Abstract: Lane. Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial (CLEAR III Trial) Lancet 2017;epublished January 9th
- Abstract: Anderson. Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study. Lancet 2017;epublished January 16th
- Abstract: Terayama. Polymyxin B Hemoperfusion for Sepsis and Septic Shock: A Systematic Review and Meta-Analysis. Surg Infect (Larchmt) 2017;epublished January 16th
- Abstract: Ni. Can high-flow nasal cannula reduce the rate of endotracheal intubation in adult patients with acute respiratory failure compared with conventional oxygen therapy and noninvasive positive pressure ventilation? A systematic review and meta-analysis. Chest 2017;epublished January 13th
- Abstract: Eljaiek. Albumin administration for fluid resuscitation in burn patients: A systematic review and meta-analysis. Burns 2017;43(1):17–24
- Abstract: Junior. Sedation protocols versus daily sedation interruption: a systematic review and meta-analysis. Rev Bras Ter Intensiva 2016;28(4):444-451
- Abstract: Nathan. Methylprednisolone for the Treatment of Patients with Acute Spinal Cord Injuries: A Systematic Review and Meta-Analysis. Journal of Neurotrauma 2016;33(5):468-481
- Abstract: Raith. Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit. JAMA 2017;317(3):290-300
- Abstract: Freund. Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department. JAMA 2017;317(3):301-308
- Full Text: Wollersheim. Whole-body vibration to prevent intensive care unit-acquired weakness: safety, feasibility, and metabolic response. Critical Care 2017;21:9
- Abstract: Dinglas. Muscle Weakness and 5-Year Survival in Acute Respiratory Distress Syndrome Survivors. Crit Care Med 2017;January 6th
- Abstract: Scott. Association Between Early Lactate Levels and 30-Day Mortality in Clinically Suspected Sepsis in Children. JAMA Pediatr 2017;epublished January 9th
- Abstract: Kratz. Impact of Focused Intraoperative Transthoracic Echocardiography by Anesthesiologists on Management in Hemodynamically Unstable High-Risk Noncardiac Surgery Patients. J Cardiothorac Vasc Anesth 2016;epublished November 2nd
- Shepherd. Review of Critical Illness Myopathy and Neuropathy. Neurohospitalist 2017;7(1):41–48
- Peter. A State-of-the-Science Overview of Randomized Controlled Trials Evaluating Acute Management of Moderate-to-Severe Traumatic Brain Injury. Journal of Neurotrauma 2016;33(16):1461-1478
- Margale. Clinical application of point of care transthoracic echocardiography in perioperative period. Indian J Anaesth 2017;61:7-16
- Corrêa. Balanced crystalloids for septic shock resuscitation. Rev Bras Ter Intensiva 2016;28(4):463-471
- Guglin.What did we learn about VADs in 2016? The VAD Journal 2017;(3):1
- Johnson. Concise Review: Mesenchymal Stromal Cell-Based Approaches for the Treatment of Acute Respiratory Distress and Sepsis Syndromes. STEM CELLS Translational Medicine 2017;epublished January 9th
- Trebicka. Emergency TIPS in a Child-Pugh B patient: When does the window of opportunity open and close? J Hepatology 2017;66(2):442-450
- Berisavac. How to recognize and treat metabolic encephalopathy in Neurology intensive care unit. Neurol India 2017;65(1):123-128
- Lanziotti. Use of biomarkers in pediatric sepsis: literature review. Rev Bras Ter Intensiva. 2016;28(4):472-482
- Martin. The basic principles of anesthesia for the neonate. Colombian Journal of Anesthesiology 2017;45(1):54–61
- Bayter-Marína. Hypothermia in elective surgery: The hidden enemy. Colombian Journal of Anesthesiology 2017;45(1):48-53
- Dwivedi. Survival analysis: A brief note. J Curr Res Sci Med 2016;2:73-9
- Bhave. Regulatory environment for clinical research: Recent past and expected future. Perspect Clin Res 2017;8:11-6
- Thatte. Ethics Committees in India: Past, present and future. Perspect Clin Res 2017;8:22-30
- Mallath. Investigators' viewpoint of clinical trials in India: Past, present and future. Perspect Clin Res 2017;8:31-6
- Nanivadekar. Clinical research: A personal perspective. Perspect Clin Res 2017;8:37-40
- Lele. Development of statistics as a discipline for clinical research: Past, present, and future. Perspect Clin Res 2017;8:41-4
- Sharma. Development of medical writing in India: Past, present, and future. Perspect Clin Res 2017;8:45-50
- Ventilation-induced lung injury exists in spontaneously breathing patients with acute respiratory failure. Intensive Care Med 2017;epublished January 10th
- Pickkers. Towards precision medicine for sepsis patients. Critical Care 2017;21:11
- Kleinpell. Promoting early identification of sepsis in hospitalized patients with nurse-led protocols. Critical Care 2017;21:10
- Buchbinder. Extremis. A Documentary Look at End-of-Life Decisions in the ICU. JAMA 2017;317(3):240-241
- Machado. Getting a consensus: advantages and disadvantages of Sepsis 3 in the context of middle-income settings. Rev Bras Ter Intensiva 2016;28(4):361-365
- Kohn. The implications of intensive care unit capacity strain for the care of critically ill patients. Rev Bras Ter Intensiva 2016;28(4):366-368
- Singer. How could we make nutrition in the intensive care unit simple? Rev Bras Ter Intensiva 2016;28(4):369-372
- Awdish. A View from the Edge — Creating a Culture of Caring. N Engl J Med 2017;376:7-9
- Steiner. Should we assume that hypothermia is a dysfunction in sepsis? Critical Care 2017;21:8
- Egbers. Communicating with conscious mechanically ventilated critically ill patients: let them speak with deflated cuff and an in-line speaking valve! Critical Care 2017;21:7
- Sutt. Patients want to be heard–loud and clear! Critical Care 2017;21:6
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
The first release of tickets for Das SMACC sold out in just 2.5 hours this week. The next opportunity will be on February 1st (depending on where you are in the world). If you haven't yet checked out the programme and workshops, then have a look on the SMACC website. The Hardcore Intensive Care workshop being organised by Steve Mathieu and Sarah Yong will cover all your critical care questions.
The Canadian Critical Care Conference (www.canadiancriticalcare.CA; @CriticalCareCa) is rather special. Not only a spectacular location (world famous Whistler, British Columbia, Canada) but also the world's finest downhill skiing, cross-country skiing, and mountain village location (did we mention it's in Whistler?). Located at the lovely Four Seasons Resort, we offer a meeting crammed with world renown speakers but in a more laid back, interactive, and reinvigorating setting that your typical medical conference. We cover all of the core science and latest research, but do not shy away from all those topics that make for a great, or not so great, patient care. This includes human factors, burnout and resilience, end-of-life care, multidisciplinary care, social media, organ donation, and the patient perspective. We are always kean to engage trainees and nurses, we offer world class precourses, and we ensure time to enjoy all that makes Whistler and Blackcomb so special. We have no desire to be the world's largest acute care conference. Rather we want to create something unique: an opportunity to learn; to interact, to have fun, and to leave more refreshed and engaged. Come and join us.
(Image from Chensiyuan via Wikipedia)
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week