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CCR Book 2018

Summarising, critiquing and putting in context the best critical care trials of 2017

We also provide one page summaries of the "best of the rest" trials, as well as a collection of the best free critical care guidelines

Included Circulatory Trials

ATHOS-3 Trial

Angiotensin II for the treatment of vasodilatory shock

CULPRIT-SHOCK Trial

Culprit vessel only versus multi-vessel revascularisation in cardiogenic shock

CHEETAH Trial

Levosimendan for haemodynamic support after cardiac surgery

TTH48 Trial

48 vs 24 hours of targeted temperature management post cardiac arrest

THAPCA-IH Trial

Therapeutic hypothermia after cardiac arrest in children

Included Trials

Video laryngoscopy in ICU

MACMAN

MACMAN compared video laryngoscopy with direct laryngoscopy for intubationin the ICU

Lung recruitment in ARDS

ART

ART was a large scale international trial investigating the use of lung recruitment and titrated PEEP in patients with ARDS

Age of transfused red cells

TRANSFUSE

TRANSFUSE compared the transfusion of the freshest available red cells with the oldest available red cells in critically ill patients

Simvastatin for delirium

MODUS

MODUS investigated simvastatin as both a prophylactic and therapeutic agent for delirium in the ICU

Book Authors

Dr Dominic Trainor

After completing an intercalated degree in Medical Genetics, Dominic graduated with honours from The Queen’s University of Belfast in 2002. He undertook a Fellowship at The Alfred Hospital, Melbourne, from 2013-2014, where he was awarded "Registrar of the Year". Special interests include end of life care and focused intensive care echocardiography. He is currently clinical lead for organ donation in The Royal Victoria Hospital, Belfast.

Dr Chris Gowers

Chris Gowers is a Consultant in ICM and Anaesthesia in the Ulster Hospital, Belfast. He qualifed from Nottingham University in 1997 and trained in Engand, Australia and Northern Ireland. He is currently the hospital’s FICM tutor and has interests in teaching, cycling and end-of-life care.

Dr Peter McGuigan

Peter McGuigan is a consultant in ICM & anaesthesia in the Royal Victoria Hospital, Belfast. He attended Queen’s University Belfast and trained in Northern Ireland. He subsequently undertook a fellowship in the Royal Melbourne Hospital, Australia where he developed an interest in clinical governance. His main clinical interests are in post cardiac arrest care and anaesthesia for head and neck surgery.

Dr Chris Nutt

Chris is an intensivist & anaesthetist in the Royal Victoria Hospital, Belfast. He graduated from Queen’s University Belfast in 2001 and began training in Anaesthesia and Intensive Care in 2003. He has a strong research interest, publishing on pre operative risk assessment & has collaborated on several major international trials.

Dr Rob Mac Sweeney

Rob is an intensivist in the Regional Intensive Care Unit at the Royal Victoria Hospital, Belfast. He attended medical school at University College Dublin, undertook a PhD at Queen’s University Belfast and completed his anaesthetic and ICM training in Northern Ireland. He started Critical Care Reviews in 2009.

Included Trials

Systematic ICU Admission in the Elderly

ICU-CUB2 Trial

Hypertonic Saline & Hyperoxia in Septic Shock

HYPERS2S Trial

Enteral vs Parenteral nutrition in Shock

NUTRIREA-2 Trial

Withholding PPI stress ulcer prophylaxis

REVISE Trial

Immunoglobulin G in soft tissue infections

INSTINCT Trial

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